The Cleveland Digestive Diseases Research Core Center (DDRCC)

克利夫兰DDRCC总体项目总结 这一竞争性更新申请是为了获得克利夫兰消化疾病的持续资助 研究核心中心（DDRCC），这是一个共同努力，凯斯西储大学 （CWRU）和克利夫兰诊所基金会（CCF）。克利夫兰DDRCC的使命是：1）提高 中心研究人员的研究能力，2）开发和实施方案，以支持独立的 培养年轻的研究人员，3）吸引目前未参与消化道疾病研究的知名研究人员 疾病研究，以应用他们的专业知识，这一重要领域的调查，和4）促进翻译 将基础研究的发现带到临床竞技场。这个跨机构和多学科的中心 目前包括47名正式成员和35名准成员，来自25个不同的学术部门， CWRU和国家合作框架，在上一个供资周期中稳步扩大。所有这些 调查人员组成了该中心的研究基地，目前该中心拥有1730万美元的同行研究经费， 审查了联邦和基金会赠款（52个NIH，5个DOD/VA，10个私人基金会赠款），特别是与以下方面有关的赠款： 克利夫兰DDRCC的两个科学主题：消化道炎症/肿瘤发生和肝脏 疾病/代谢。这两个方案领域有着良好的合作历史记录。 在CWRU和CCF的调查，并已显示出显着增长的合作，在过去的 融资周期。该中心享有强有力的机构支持，包括承诺提供重要的配套服务， 来自CWRU和CCF的资金，以增加消化系统疾病研究在两个机构的影响。 该中心包括三个生物医学研究核心，以支持这个强大的研究基地：1）生物储存库 核心，2）组织学/成像核心，和3）小鼠模型核心，所有这些都表现出高水平 的使用，并促进了消化系统疾病的重要科学发现， 上一个融资周期。每个核心都包括一组高容量标准服务， 作为一种共享资源，可以优化成本效益和质量控制， 中心研究者可能无法获得的先进服务和技术。核心 实验室与行政核心接口，行政核心还支持成功的试点和可行性研究 计划，以促进创新的研究项目，由研究人员谁是新的消化领域 疾病行政核心监督克利夫兰复员方案协调中心的财务管理和运作 并支持临床元素，以及支持会议的动态丰富计划， 中西部DDRCC研究联盟和两个克利夫兰国际消化教育和科学 （IDEAS）上一个供资周期的专题讨论会。克利夫兰DDRCC的总体目标是 为中心成员增加核心资源的可用性，并促进研究，合作和新的 在消化系统疾病的研究方向，导致重要的科学发现。

CLEVELAND DDRCC OVERALL PROJECT SUMMARY This competitive renewal application is to obtain continued funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC's mission is to: 1) enhance the research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators, 3) attract established investigators not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translation of basic research discoveries to the clinical arena. This cross-institutional and multi-disciplinary Center currently includes 47 full members and 35 associate members from 25 different academic departments across CWRU and the CCF, representing a steady expansion during the previous funding cycle. Together, these investigators comprise the Research Base for the Center, which currently consists of $17.3 million in peer- reviewed federal and foundation grants (52 NIH, 5 DOD/VA, 10 private foundation grants) specifically related to the two scientific themes of the Cleveland DDRCC: Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. These two programmatic areas have strong historical track records of collaborative investigation at CWRU and the CCF and have shown significant growth in collaboration during the previous funding cycle. The Center enjoys strong institutional support, including a commitment of significant matching funds from both CWRU and the CCF to increase the impact of digestive disease research at both institutions. The Center includes three biomedical research cores to support this strong Research Base: 1) a Biorepository Core, 2) an Histology/Imaging Core, and 3) a Mouse Models Core, all of which have demonstrated high levels of usage by Center members and promoted important scientific discoveries in digestive diseases during the previous funding cycle. Each Core includes both a set of high-volume standard services that are best provided as a shared resource that can optimize cost-efficiency and quality control, as well as more cutting-edge advanced services and technologies that may not otherwise be available to Center investigators. The Core laboratories interface with a Administrative Core, which also supports a successful Pilot and Feasibility Program to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core oversees the financial management and operation of the Cleveland DDRCC and supports a Clinical Element, as well as a dynamic Enrichment Program that has supported the meetings of the Midwest DDRCC Research Alliance and two Cleveland International Digestive Education and Science (IDEAS) Symposia during the previous funding cycle. The overall objective of the Cleveland DDRCC is to increase the availability of Core resources for Center members, and to foster research, collaborations, and new directions in digestive disease research, leading to important scientific discoveries.