The Cleveland Digestive Diseases Research Core Center (DDRCC)

克利夫兰DDRCC总体项目总结 这项竞争性续签申请是为了获得克利夫兰消化系统疾病的持续资金 研究核心中心(DDRCC)，这是凯斯西部储备大学与 (CWRU)和克利夫兰临床基金会(CCF)。克利夫兰DDRCC的使命是：1)加强 中心调查人员的研究能力，2)开发和实施项目以支持独立的 培养年轻的研究人员，3)吸引目前未参与消化研究的知名研究人员 疾病研究将他们的专业知识应用到这一重要的调查领域，并4)促进翻译 将基础研究发现推广到临床领域。这个跨机构、多学科的中心 目前包括47个正式成员和35个准成员，来自25个不同的学术部门 CWRU和CCF，在上一个供资周期中稳步扩大。加在一起，这些 研究人员组成了该中心的研究基地，目前由1730万美元的同行- 审查联邦和基金会赠款(52个国家卫生研究院，5个国防部/退伍军人事务部，10个私人基金会赠款)，具体涉及 克利夫兰DDRCC的两个科学主题：消化系统炎症/肿瘤发生和肝脏 疾病/新陈代谢。这两个计划领域有很强的协作历史记录 CWRU和CCF的调查显示，在过去的几年中，合作显著增长 资金周期。该中心享有强有力的机构支持，包括作出重大配套承诺 来自CWRU和CCF的资金，以增加这两个机构的消化系统疾病研究的影响。 该中心包括三个生物医学研究核心，以支持这一强大的研究基础：1)生物仓库 核心，2)组织学/成像核心，3)小鼠模型核心，所有这些都表现出高水平 促进了消化系统疾病方面的重大科学发现 上一个资金周期。每个核心都包括一组最好地提供的大容量标准服务 作为可以优化成本效益和质量控制的共享资源，以及更尖端的 中心调查人员可能无法获得的高级服务和技术。《核心》 实验室与管理核心对接，这也支持成功的试点和可行性 促进消化领域新手研究人员开展创新研究项目的计划 疾病。行政核心监督克利夫兰DDRCC的财务管理和运作 并支持临床元素以及动态充实计划，该计划支持 中西部DDRCC研究联盟和两个克利夫兰国际消化教育和科学 (想法)上一个供资周期的专题讨论会。克利夫兰复员方案协调委员会的总体目标是 提高中心成员的核心资源可用性，并促进研究、协作和新的 消化疾病研究的方向，导致重要的科学发现。

CLEVELAND DDRCC OVERALL PROJECT SUMMARY This competitive renewal application is to obtain continued funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC's mission is to: 1) enhance the research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators, 3) attract established investigators not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translation of basic research discoveries to the clinical arena. This cross-institutional and multi-disciplinary Center currently includes 47 full members and 35 associate members from 25 different academic departments across CWRU and the CCF, representing a steady expansion during the previous funding cycle. Together, these investigators comprise the Research Base for the Center, which currently consists of $17.3 million in peer- reviewed federal and foundation grants (52 NIH, 5 DOD/VA, 10 private foundation grants) specifically related to the two scientific themes of the Cleveland DDRCC: Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. These two programmatic areas have strong historical track records of collaborative investigation at CWRU and the CCF and have shown significant growth in collaboration during the previous funding cycle. The Center enjoys strong institutional support, including a commitment of significant matching funds from both CWRU and the CCF to increase the impact of digestive disease research at both institutions. The Center includes three biomedical research cores to support this strong Research Base: 1) a Biorepository Core, 2) an Histology/Imaging Core, and 3) a Mouse Models Core, all of which have demonstrated high levels of usage by Center members and promoted important scientific discoveries in digestive diseases during the previous funding cycle. Each Core includes both a set of high-volume standard services that are best provided as a shared resource that can optimize cost-efficiency and quality control, as well as more cutting-edge advanced services and technologies that may not otherwise be available to Center investigators. The Core laboratories interface with a Administrative Core, which also supports a successful Pilot and Feasibility Program to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core oversees the financial management and operation of the Cleveland DDRCC and supports a Clinical Element, as well as a dynamic Enrichment Program that has supported the meetings of the Midwest DDRCC Research Alliance and two Cleveland International Digestive Education and Science (IDEAS) Symposia during the previous funding cycle. The overall objective of the Cleveland DDRCC is to increase the availability of Core resources for Center members, and to foster research, collaborations, and new directions in digestive disease research, leading to important scientific discoveries.