The Cleveland Digestive Diseases Research Core Center (DDRCC)

描述(申请人提供)：这份修改后的申请是为了获得克利夫兰消化疾病研究核心中心(DDRCC)的资金，该中心是凯斯西储大学(CWRU)和克利夫兰临床基金会(CCF)共同努力的结果。克利夫兰DDRCC是一个跨机构和多学科的项目，包括来自15个不同学术部门的34名正式成员和18名准成员。该中心的两个主要主题是消化炎症和新陈代谢，这两个主题都代表了CWRU和CCF合作研究的成熟领域。拟议中的克利夫兰DDRCC将：1)增强中心研究人员的基础研究能力，2)开发和实施项目，以支持消化系统炎症和代谢研究领域年轻研究人员的独立发展，3)吸引目前尚未参与消化疾病研究的具有不同专业知识的知名研究人员将他们的专业知识应用于这一重要研究领域，以及4)促进将基础研究发现转化为临床领域。我们有强大的机构支持，包括130万美元的初始投资，以增加两个机构的消化系统疾病研究的影响。该中心的研究基地包括1500万美元的联邦拨款(48 NIH，1 DOD，1 VA，1 NSF)，专门与消化系统炎症和代谢有关，其中51%的资金直接来自NIDDK(760万美元)。我们提出了3个科学核心来支持这一强大的研究基础：1)生物信息库核心，2)组织学/成像核心，3)小鼠模型核心。这些核心实验室与组织良好的管理核心相联系，管理核心还支持试点/可行性和命名的新调查者计划，以促进消化疾病领域新手的研究人员的创新研究项目。行政核心还包括一个充实计划和一个临床部分，并监督克利夫兰DDRCC的财务管理和运作。克利夫兰DDRCC的总体目标是为中心成员增加核心资源的可用性，并促进消化系统疾病研究的研究、合作和新方向。

DESCRIPTION (provided by applicant): This revised application is being submitted to obtain funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC is a cross-institutional and multi-disciplinary program, including 34 full members and 18 associate members from 15 different academic departments. The Center's two major themes are Digestive Inflammation and Metabolism, both of which represent well established areas of collaborative investigation at CWRU and the CCF. The proposed Cleveland DDRCC will: 1) enhance the basic research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators in Digestive Inflammation and Metabolism research, 3) attract established investigators with varied expertise who are not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translationof basic research discoveries to the clinical arena. We have strong institutional support, including an initial investment of $1.3 million to increase the impact of digestive disease research at both institutions. The Research Base for the Center consists of $15 0 million in federal grants (48 NIH, 1 DOD, 1 VA, 1 NSF) specifically related to Digestive Inflammation and Metabolism, with 5 1% of these funds coming directly from the NIDDK ($7.6 million). We are proposing 3 scientific cores to support this strong Research Base: 1) BioRepository Core, 2) Histology/Imaging Core, and 3) Mouse Models Core. These core laboratories interface with a well-organized Administrative Core, which also supports Pilot/Feasibility and Named New Investigator Programs to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core also includes an Enrichment Program and a Clinical Component, and oversees the financial management and operation of the Cleveland DDRCC. The overall objective of the Cleveland DDRCC is to increase the availability of core resources for Center members, and foster research, collaborations, and new directions in digestive disease research.