The Case Medical Student Summer Research Program (MSSRP)

项目总结 此T35竞争续签申请要求继续为Case医科学生暑期活动提供资金 研究计划(MSSRP)。该计划的总体目标是促进医生的职业发展 将选择生物医学研究作为其长期职业生涯的重要组成部分的科学家 发展，特别注重NIDDK的任务领域和与NIDDK相关的研究。这些 包括：1)消化系统疾病，2)肝脏疾病，3)糖尿病和代谢疾病，4)肾脏疾病，5) 胃肠道肿瘤发生；6)炎症/感染。该项目使用导师来教育医学生- 在他们医学院一年级到二年级之间为期8周的培训期间，采用基于研究的方法。 T35项目基于战略规划、统一的努力和紧密的学术整合 CWRU医学院(SOM)、大学医院(UH)克利夫兰医学中心、克利夫兰诊所、 MetroHealth和路易斯斯托克斯退伍军人医疗中心，后者提供了一流的方案基础设施。 来自这些机构的教师导师凭借卓越的临床和 基础研究，来自NIDDK和NIDDK相关机构的充足资金(每年直接成本3980万美元，来自 NIH；仅NIDDK就有1510万美元)，研究空间加起来超过10万平方英尺。案例MSSRP 有通过正式申请挑选高素质医学生的既定记录，以及 从研究领域的研究人员中确定研究项目和导师的评估过程 与NIDDK任务有关。项目评估和学生进度由T35高管和 内部咨询委员会。学生提交一份书面摘要，并在Lepow期间展示他们的发现 医科学生研究日在九月举行。该程序的一个独特方面是多PI/PD 方法，允许研究跨越部门边界，并招募具有 高效的协作，并培训了大量年轻调查人员 跨学科的方式。来自19个部门的50名导师，代表了广泛的研究 专业知识提供了为每个受训者的科学兴趣量身定做的多种研究机会。 我们的创新课程包括每周小组会议、授课讲座和为期三天的实践课程。 在为期8周的研究期开始时举行。为了评估该计划的长期影响，我们合作 与医学教育和校友事务办公室一起跟踪医科学生毕业后长达20年的情况。 基于上一次资助期间的大量申请者，我们要求扩大 NIDDK的支持每年增加5名学生(总共15名NIDDK支持的受训人员)。我们有很强的 体制支助，通过提供空间和资源、费用分担以及来自 CTSC和NIDDK资助的克利夫兰DDRCC。因此，学术环境继续保持理想。 为了维持这一以NIDDK为重点的T35医学生短期培训计划的总体目标。

PROJECT SUMMARY This T35 competitive renewal application requests continued funding for the Case Medical Student Summer Research Program (MSSRP). The overall goal of the program is to promote career development for physician scientists who will choose biomedical investigation as an essential component of their long-term professional development, with particular focus on the mission areas of the NIDDK and NIDDK-related research. These include: 1) Digestive Diseases, 2) Liver Diseases, 3) Diabetes & Metabolic Diseases, 4) Kidney Diseases, 5) GI Tumorigenesis, and 6) Inflammation/Infection. The program educates medical students using a mentor- based research approach over an 8-week training period between their 1st and 2nd years of medical school. The T35 program is based on strategic planning, consolidated efforts, and close academic integration of the CWRU School of Medicine (SoM), University Hospitals (UH) Cleveland Medical Center, the Cleveland Clinic, MetroHealth, and the Louis Stokes VA Medical Center, which provides a superb programmatic infrastructure. The faculty mentors from these institutions sustain a reputation of excellence based on superior clinical and basic research, ample funding from the NIDDK and NIDDK-related institutes ($39.8M annual direct costs from NIH; $15.1M from NIDDK alone), and combined research space in excess of 100,000 ft2. The Case MSSRP has an established track-record of selecting highly-qualified medical students through a formal application and evaluation process that identifies a research project and mentor from investigators working in a research area related to the NIDDK mission. Program evaluation and student progress is overseen by the T35 Executive and Internal Advisory Committees. Students submit a written abstract and present their findings during the Lepow Medical Student Research Day held in September. A unique aspect of the program is the multiple PI/PD approach, which allows research to span departmental boundaries and enlist preceptors with a tradition of highly-productive collaboration and who have trained a large number of young investigators in an interdisciplinary manner. The 50 mentors from 19 departments, representing a wide range of research expertise, offer a multiplicity of research opportunities that are tailored to the scientific interest of each trainee. Our innovative curriculum includes weekly group meetings, didactic lectures, and a three-day hands-on course held at the start of the 8-week research period. To assess the long-term impact of the program, we collaborate with the Medical Education and Alumni Affairs offices to track medical students up to 20 years after graduation. Based on the high number of applicants during the previous funding period, we are requesting to expand NIDDK support by an additional 5 students per year (15 total NIDDK-supported trainees). We have strong institutional support, documented by provision of space and resources, cost-sharing, as well as support from the CTSC and NIDDK-funded Cleveland DDRCC. Therefore, the academic environment continues to be ideal to sustain the overall objectives of this NIDDK-focused T35 medical student short-term training program.