Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk Program

环境暴露和癌症风险计划队列协调中心

• 批准号: 10557188
• 负责人: Kristen Mary Chossek Malecki
• 金额: $ 67.99万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557188
• 关键词: Acceleration; Address; Attention; Behavioral; Biological; Cancer Biology; Cancer Burden; Cancer Center; Cancer Etiology; Cancer Science; Cessation of life; Chemicals; Cohort Studies; Collaborations; Common Data Element; Communication; Communities; Data; Data Science; Deposition; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Environmental Science; Exclusion; Fostering; Genetic; Goals; Individual; Infrastructure; Investments; Knowledge; Leadership; Malignant Neoplasms; Medical; Metadata; Mission; Morbidity - disease rate; Participant; Population; Population Heterogeneity; Prevention; Process; Productivity; Public Health Practice; Reproducibility of Results; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Role; Sampling; Science; Scientific Advances and Accomplishments; Secure; Source; Structure; Technology; Toxicology; Training; Translations; Trust; United States; United States National Institutes of Health; Universities; Wisconsin; advocacy organizations; cancer epidemiology; cancer health disparity; cancer risk; career; cohort; community engagement; data dissemination; data sharing; data submission; environment related cancer; epidemiology study; evidence base; experience; health disparity populations; innovation; innovative technologies; member; mortality; multidisciplinary; outreach; prevent; programs; prospective; repository; structural determinants; web site; webinar

While scientific and medical advances have dramatically increased our ability to prevent, detect and treat cancer, gaps remain regarding the impact of environmental exposures—particularly chemical and physical factors—on cancer risk. The overarching goal of this application is to build collaborative infrastructure and facilitate transdisciplinary scientific research for enhancing our understanding of environmental exposures influencing cancer etiology, and the genetic, behavioral, and structural factors that modify risk across diverse populations. We propose to serve as the Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk (CEECR) Program. Our mission is to provide intellectual leadership and logistical and collaborative infrastructure for the CEECR program by integrating efforts across the CEECR cohorts, facilitating research activities, identifying opportunities for cross-CEECR collaboration, and disseminating research findings through partnerships with stakeholders. We will draw upon extensive experience coordinating large-scale consortia, conducting prospective cancer epidemiology studies, and engaging with community partners to support the CEECR Program. We will facilitate cooperation across the CEECR cohorts to achieve their UG3/UH3 milestones and realize their full potential as an integrated sustained powerful source of knowledge for characterizing the impact of environmental exposures on cancer risk. Specific Aims include: 1) providing intellectual leadership and multidisciplinary scientific expertise, establishing a governance structure, and identifying opportunities to catalyze cross-cohort collaboration; 2) assisting with the identification of common data elements and the integration of research efforts regarding biological samples and innovative technologies; 3) facilitating innovative transdisciplinary research by developing evidence-based infrastructure to support collaboration, coordination, communication, outreach and engagement, and career enhancement; and 4) fostering resource sharing by CEECR members with external researchers and stakeholders—including the deposition of data in NIH repositories—to accelerate research and move findings towards translation and prevention. Our multidisciplinary team includes experts in cancer epidemiology, environmental health, team science, cancer health disparities, cancer biology, toxicology, data science, applied public health practice, outreach/community engagement, and research administration. The University of Wisconsin Carbone Cancer Center provides the ideal environment for supporting the Coordinating Center due to its resources and established relationships with local and national research and advocacy organizations. The CEECR Coordinating Center will use multiple innovative approaches to leverage program members’ common passion for elucidating the role of environmental factors in cancer etiology, provide expanded opportunities for collaboration, and enable the CEECR Program to bring about substantive reductions in the cancer burden paying special attention to populations historically excluded from the full benefits of scientific advances.

虽然科学和医学的进步极大地提高了我们预防、检测和治疗 在癌症方面，在环境暴露--特别是化学和物理暴露--的影响方面仍然存在差距 影响癌症风险的因素。此应用程序的总体目标是构建协作基础设施和 促进跨学科科学研究，以加强我们对环境暴露的了解 影响癌症病因学，以及改变各种不同风险的遗传、行为和结构因素 人口。我们建议担任环境暴露队列的协调中心和 癌症风险(CEECR)计划。我们的使命是提供智力领导和后勤以及 通过整合整个CEECR群体的努力，为CEECR计划提供协作基础设施， 促进研究活动，确定跨中欧经合组织合作的机会，并传播 通过与利益攸关方建立伙伴关系获得研究成果。我们将借鉴丰富的经验。 协调大型财团，进行前瞻性癌症流行病学研究，并参与 社区合作伙伴支持CEECR计划。我们将促进中东欧国家之间的合作。 实现他们的UG3/UH3里程碑，并实现他们作为一个综合的、持续的强大来源的全部潜力 描述环境暴露对癌症风险的影响的知识。具体目标包括： 1)提供智力领导和多学科科学专长，建立一种治理 结构，并确定促进跨队列协作的机会；2)协助确定 共同数据元素和整合有关生物样本和创新的研究工作 技术；3)通过发展基于证据的基础设施，促进创新的跨学科研究 支持协作、协调、沟通、外展和参与以及职业发展； 以及4)促进经济、社会和文化权利中心成员与外部研究人员和利益攸关方共享资源--包括 将数据存储在NIH存储库中-以加速研究并将结果转化为 预防。我们的多学科团队包括癌症流行病学、环境健康、团队 科学，癌症健康差异，癌症生物学，毒理学，数据科学，应用公共卫生实践， 外展/社区参与和研究管理。威斯康星大学的碳骨癌 中心的资源和资源为协调中心提供了理想的支持环境 与地方和国家研究和倡导组织建立了关系。中欧经济合作研究中心 协调中心将使用多种创新方法来利用计划成员的共同热情 为了阐明环境因素在癌症病因中的作用，提供了更多的机会 合作，并使CEECR方案能够实质性地减少癌症负担 特别关注历史上被排除在科学进步充分惠益之外的人群。