Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk Program

环境暴露和癌症风险计划队列协调中心

• 批准号: 10557188
• 负责人: Kristen Mary Chossek Malecki
• 金额: $ 67.99万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557188
• 关键词: Acceleration; Address; Attention; Behavioral; Biological; Cancer Biology; Cancer Burden; Cancer Center; Cancer Etiology; Cancer Science; Cessation of life; Chemicals; Cohort Studies; Collaborations; Common Data Element; Communication; Communities; Data; Data Science; Deposition; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Environmental Science; Exclusion; Fostering; Genetic; Goals; Individual; Infrastructure; Investments; Knowledge; Leadership; Malignant Neoplasms; Medical; Metadata; Mission; Morbidity - disease rate; Participant; Population; Population Heterogeneity; Prevention; Process; Productivity; Public Health Practice; Reproducibility of Results; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Role; Sampling; Science; Scientific Advances and Accomplishments; Secure; Source; Structure; Technology; Toxicology; Training; Translations; Trust; United States; United States National Institutes of Health; Universities; Wisconsin; advocacy organizations; cancer epidemiology; cancer health disparity; cancer risk; career; cohort; community engagement; data dissemination; data sharing; data submission; environment related cancer; epidemiology study; evidence base; experience; health disparity populations; innovation; innovative technologies; member; mortality; multidisciplinary; outreach; prevent; programs; prospective; repository; structural determinants; web site; webinar

While scientific and medical advances have dramatically increased our ability to prevent, detect and treat cancer, gaps remain regarding the impact of environmental exposures—particularly chemical and physical factors—on cancer risk. The overarching goal of this application is to build collaborative infrastructure and facilitate transdisciplinary scientific research for enhancing our understanding of environmental exposures influencing cancer etiology, and the genetic, behavioral, and structural factors that modify risk across diverse populations. We propose to serve as the Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk (CEECR) Program. Our mission is to provide intellectual leadership and logistical and collaborative infrastructure for the CEECR program by integrating efforts across the CEECR cohorts, facilitating research activities, identifying opportunities for cross-CEECR collaboration, and disseminating research findings through partnerships with stakeholders. We will draw upon extensive experience coordinating large-scale consortia, conducting prospective cancer epidemiology studies, and engaging with community partners to support the CEECR Program. We will facilitate cooperation across the CEECR cohorts to achieve their UG3/UH3 milestones and realize their full potential as an integrated sustained powerful source of knowledge for characterizing the impact of environmental exposures on cancer risk. Specific Aims include: 1) providing intellectual leadership and multidisciplinary scientific expertise, establishing a governance structure, and identifying opportunities to catalyze cross-cohort collaboration; 2) assisting with the identification of common data elements and the integration of research efforts regarding biological samples and innovative technologies; 3) facilitating innovative transdisciplinary research by developing evidence-based infrastructure to support collaboration, coordination, communication, outreach and engagement, and career enhancement; and 4) fostering resource sharing by CEECR members with external researchers and stakeholders—including the deposition of data in NIH repositories—to accelerate research and move findings towards translation and prevention. Our multidisciplinary team includes experts in cancer epidemiology, environmental health, team science, cancer health disparities, cancer biology, toxicology, data science, applied public health practice, outreach/community engagement, and research administration. The University of Wisconsin Carbone Cancer Center provides the ideal environment for supporting the Coordinating Center due to its resources and established relationships with local and national research and advocacy organizations. The CEECR Coordinating Center will use multiple innovative approaches to leverage program members’ common passion for elucidating the role of environmental factors in cancer etiology, provide expanded opportunities for collaboration, and enable the CEECR Program to bring about substantive reductions in the cancer burden paying special attention to populations historically excluded from the full benefits of scientific advances.

虽然科学和医学的进步大大提高了我们预防、检测和治疗的能力， 癌症，差距仍然存在的影响，环境灾害，特别是化学和物理 癌症风险的因素。此应用程序的首要目标是构建协作基础设施， 促进跨学科的科学研究，以提高我们对环境暴露的认识 影响癌症病因学的遗传、行为和结构因素，这些因素改变了各种癌症的风险。 人口。我们建议作为环境暴露群体的协调中心， 癌症风险（CEECR）计划。我们的使命是提供智力领导和后勤， 通过整合整个CEECR群组的努力，为CEECR计划提供协作基础设施， 促进研究活动，确定跨CEECR合作的机会，并传播 通过与利益相关者的伙伴关系进行研究。我们将利用广泛的经验 协调大型联盟，进行前瞻性癌症流行病学研究，并与 社区合作伙伴支持CEECR计划。我们将促进中欧和东欧国家之间的合作 实现其UG 3/UH 3里程碑，并充分发挥其作为一个综合的、持续的强大能源的潜力 描述环境暴露对癌症风险影响的知识。具体目标包括： 1)提供知识领导和多学科科学专门知识，建立一个治理机制， 结构，并确定促进跨队列合作的机会; 2）协助确定 共同数据元素的整合以及生物样本和创新研究工作的整合 技术; 3）通过发展循证基础设施促进创新的跨学科研究 支持协作、协调、沟通、外联和参与以及职业提升; 以及4）促进CEECR成员与外部研究人员和学术界人士的资源共享，包括 将数据存储在NIH存储库中，以加速研究并将研究结果转化为 预防我们的多学科团队包括癌症流行病学，环境健康，团队 科学，癌症健康差异，癌症生物学，毒理学，数据科学，应用公共卫生实践， 外展/社区参与和研究管理。威斯康星州大学碳骨癌 中心提供了理想的环境，支持协调中心，由于其资源和 与地方和国家研究和宣传组织建立了关系。CEECR 协调中心将使用多种创新方法来利用计划成员的共同热情 为阐明环境因素在癌症病因学中的作用， 合作，并使CEECR计划能够大幅减少癌症负担 特别关注历史上被排除在科学进步的全部利益之外的人口。