Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk Program

环境暴露和癌症风险计划队列协调中心

• 批准号: 10557188
• 负责人: Kristen Mary Chossek Malecki
• 金额: $ 67.99万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557188
• 关键词: Acceleration; Address; Attention; Behavioral; Biological; Cancer Biology; Cancer Burden; Cancer Center; Cancer Etiology; Cancer Science; Cessation of life; Chemicals; Cohort Studies; Collaborations; Common Data Element; Communication; Communities; Data; Data Science; Deposition; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Environmental Science; Exclusion; Fostering; Genetic; Goals; Individual; Infrastructure; Investments; Knowledge; Leadership; Malignant Neoplasms; Medical; Metadata; Mission; Morbidity - disease rate; Participant; Population; Population Heterogeneity; Prevention; Process; Productivity; Public Health Practice; Reproducibility of Results; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Risk; Role; Sampling; Science; Scientific Advances and Accomplishments; Secure; Source; Structure; Technology; Toxicology; Training; Translations; Trust; United States; United States National Institutes of Health; Universities; Wisconsin; advocacy organizations; cancer epidemiology; cancer health disparity; cancer risk; career; cohort; community engagement; data dissemination; data sharing; data submission; environment related cancer; epidemiology study; evidence base; experience; health disparity populations; innovation; innovative technologies; member; mortality; multidisciplinary; outreach; prevent; programs; prospective; repository; structural determinants; web site; webinar

While scientific and medical advances have dramatically increased our ability to prevent, detect and treat cancer, gaps remain regarding the impact of environmental exposures—particularly chemical and physical factors—on cancer risk. The overarching goal of this application is to build collaborative infrastructure and facilitate transdisciplinary scientific research for enhancing our understanding of environmental exposures influencing cancer etiology, and the genetic, behavioral, and structural factors that modify risk across diverse populations. We propose to serve as the Coordinating Center for the Cohorts for Environmental Exposures and Cancer Risk (CEECR) Program. Our mission is to provide intellectual leadership and logistical and collaborative infrastructure for the CEECR program by integrating efforts across the CEECR cohorts, facilitating research activities, identifying opportunities for cross-CEECR collaboration, and disseminating research findings through partnerships with stakeholders. We will draw upon extensive experience coordinating large-scale consortia, conducting prospective cancer epidemiology studies, and engaging with community partners to support the CEECR Program. We will facilitate cooperation across the CEECR cohorts to achieve their UG3/UH3 milestones and realize their full potential as an integrated sustained powerful source of knowledge for characterizing the impact of environmental exposures on cancer risk. Specific Aims include: 1) providing intellectual leadership and multidisciplinary scientific expertise, establishing a governance structure, and identifying opportunities to catalyze cross-cohort collaboration; 2) assisting with the identification of common data elements and the integration of research efforts regarding biological samples and innovative technologies; 3) facilitating innovative transdisciplinary research by developing evidence-based infrastructure to support collaboration, coordination, communication, outreach and engagement, and career enhancement; and 4) fostering resource sharing by CEECR members with external researchers and stakeholders—including the deposition of data in NIH repositories—to accelerate research and move findings towards translation and prevention. Our multidisciplinary team includes experts in cancer epidemiology, environmental health, team science, cancer health disparities, cancer biology, toxicology, data science, applied public health practice, outreach/community engagement, and research administration. The University of Wisconsin Carbone Cancer Center provides the ideal environment for supporting the Coordinating Center due to its resources and established relationships with local and national research and advocacy organizations. The CEECR Coordinating Center will use multiple innovative approaches to leverage program members’ common passion for elucidating the role of environmental factors in cancer etiology, provide expanded opportunities for collaboration, and enable the CEECR Program to bring about substantive reductions in the cancer burden paying special attention to populations historically excluded from the full benefits of scientific advances.

尽管科学和医学进步已大大提高了我们预防，检测和治疗的能力 癌症，关于环境暴露的影响仍然存在差距 - 尤其是化学和物理 因素 - 癌症风险。此应用程序的总体目标是建立协作基础架构和 促进跨学科科学研究，以增强我们对环境暴露的理解 影响癌症的病因以及改变潜水员风险的遗传，行为和结构因素 人群。我们建议作为环境暴露同伙的协调中心 癌症风险（CEECR）计划。我们的使命是提供近视领导和后勤和 CEECR计划的协作基础架构通过整合CEECR队列的努力， 促进研究活动，确定交叉协作的机会并传播 通过与利益相关者的合作伙伴关系研究结果。我们将借鉴丰富的经验 协调大规模财团，进行前瞻性癌症流行病学研究，并参与 社区合作伙伴支持CEECR计划。我们将促进整个CEECR队列的合作 实现其UG3/UH3里程碑，并实现其作为综合持续强大的来源的全部潜力 具有表征环境暴露对癌症风险的影响的知识。具体目的包括： 1）提供智力领导和多学科科学专业知识，建立治理 结构，并确定催化跨局部合作的机会； 2）协助识别 常见数据元素以及有关生物样品和创新的研究工作的整合 技术； 3）通过开发循证基础设施来促进创新的跨学科研究 支持合作，协调，沟通，外展和参与以及职业增强； 4）培养CEECR成员与外部研究人员和利益相关者的资源共享 - 包括 NIH存储库中数据的沉积 - 加速研究并将发现转移到翻译和 预防。我们的多学科团队包括癌症流行病学，环境健康，团队的专家 科学，癌症健康差异，癌症生物学，毒理学，数据科学，应用公共卫生实践， 外展/社区参与和研究管理局。威斯康星大学碳纤维癌 中心为支持协调中心的资源提供了理想的环境 与地方和国家研究和倡导组织建立了关系。 CEECR 协调中心将使用多种创新方法来利用计划成员的共同热情 为了阐明环境因素在癌症病因中的作用，为扩大的机会提供了 协作，并使CEECR计划能够实质性减少癌症伯恩（Burnen） 特别关注历史上的人口，从科学进步的全部好处中排除。