Survey of the Health of Wisconsin

威斯康星州健康调查

• 批准号: 10626522
• 负责人: Kristen Mary Chossek Malecki
• 金额: $ 3.44万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-25 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626522
• 关键词: Acceleration; Address; Advanced Malignant Neoplasm; African American; Basic Science; Behavioral; Biological; Biological Markers; Black race; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Science; Catchment Area; Cause of Death; Censuses; Clinical; Clinical Sciences; Collaborations; Collection; Communities; Community Networks; Comprehensive Cancer Center; Consultations; Coupled; DNA; Data; Data Collection; Data Set; Development; Disparity; Economic Factors; Ensure; Environmental Pollution; Epidemiologist; Epidemiology; Ethnic Origin; Ethnic Population; Etiology; Faculty; Food Access; Fostering; Funding; Goals; Health Sciences; Health Surveys; Healthcare; Housing; Incidence; Individual; Infrastructure; Instruction; Investments; Knowledge; Link; Longitudinal cohort; Longitudinal cohort study; Malignant Neoplasms; Measurement; Methods; Mission; Monitor; NCI Center for Cancer Research; Neighborhoods; Nursing Faculty; Outcome; Physical Examination; Plasma; Population; Population Heterogeneity; Population Research; Population trends; Positioning Attribute; Prevalence; Protocols documentation; Questionnaires; Race; Recording of previous events; Reporting; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Support; Resource Sharing; Resources; Risk Factors; Rural; Rural Community; Sampling; Science; Scientist; Serum; Services; Shapes; Social Sciences; Strategic Planning; Surveys; System; Translational Research; Translations; Underrepresented Populations; United States; Universities; Urine; Validation; Vital Statistics; Wisconsin; anticancer research; biobank; biomarker discovery; burden of illness; cancer prevention; cancer risk; cancer therapy; community burden; community engagement; community organizations; cost effective; data sharing networks; design; disability; disparity reduction; epidemiology study; experience; geographic disparity; high risk; improved; innovation; interdisciplinary approach; member; multimodality; novel; novel strategies; population based; population health; programs; racial population; recruit; repository; research and development; research study; rural dwellers; sample collection; social; social factors; social health determinants; trend; wearable device

PROJECT SUMMARY / ABSTRACT Cancer remains a leading cause of death and disability in the United States and significant disparities across urban and rural, as well as racial and ethnic populations, exist. Population health sciences is an interdisciplinary approach drawing on basic, clinical, and social sciences to ensure translation and dissemination of new knowledge into useful applications across multiple sectors. The Survey of the Health of Wisconsin, SHOW, is a long-standing infrastructure for population health research. Established in 2008, SHOW includes an ongoing longitudinal cohort study of individuals representing the entire state of Wisconsin. As a University of Wisconsin Carbone Cancer Center (UWCCC) shared resource (SR), SHOW provides members with an existing data collection infrastructure and access to detailed survey data, physical exam measurements and biospecimens for advancing cancer control. UWCCC has a rich history of providing survey and research study design support for members through the Cancer Prevention and Outcomes Data (C-POD) SR; which was merged with SHOW to support cancer research across the entire UWCCC catchment area. In the current CCSG cycle, the C-POD and SHOW served 35 unique UWCCC members across all six scientific programs. SHOW includes detailed survey and physical exam data describing population trends in numerous well established and emerging cancer risk factors including multiple social determinants of health. These detailed data are coupled with stored biospecimens including urine, serum, plasma and DNA on over 4,000 individual Wisconsin residents. With this unique resource, SHOW’s goal is to facilitate innovative cancer research for improved cancer prevention and control across all communities in Wisconsin. This is accomplished through 3 aims: 1) Accelerate Cancer Surveillance and Cancer Prevention and Control Research through the Use of Existing Data. SHOW’s longitudinal data are available to UWCCC members to conduct etiologic research and monitor the prevalence of known and emerging cancer risk factors across the UWCCC catchment. 2) Facilitate the Development of New Population Based Cancer Research Utilizing SHOW Expertise and Infrastructure. Independent of the core SHOW data, SHOW can support new study design and survey development, including rigorous and reproducible methods and protocols for population based biospecimen collection and storage. 3) Foster Use of SHOW Biospecimens for Novel Cancer Research. SHOW maintains an extensive biorepository and expertise to support cost effective biomarker based cancer research. Dr. Malecki (CPC), the SHOW Faculty Leader and Dr. Schultz, the Facility Manager, have over twenty years of combined experience and expertise in population based epidemiologic, community engaged, and translational research. SHOW also maintains long-standing relationships with diverse African American and rural community based organizations serving those carrying the heaviest cancer burden. These ongoing partnerships are critical for UWCCC members to disseminate findings, to advance cancer control and reduce disparities in alignment with the UWCCC Strategic Plan.

项目概要/摘要 癌症仍然是美国死亡和残疾的主要原因，而且各个国家之间存在巨大差异 城市和农村以及种族和族裔人口都是存在的。人口健康科学是一门交叉学科 借鉴基础、临床和社会科学的方法，确保新知识的翻译和传播 将知识转化为跨多个部门的有用应用。威斯康星州健康调查 (SHOW) 是一项 人口健康研究的长期基础设施。 SHOW 成立于 2008 年，包括正在进行的 对代表整个威斯康星州的个人进行的纵向队列研究。作为威斯康星大学 Carbone癌症中心（UWCCC）共享资源（SR），SHOW为会员提供现有数据 收集基础设施并获取详细的调查数据、体检测量结果和生物样本 推进癌症控制。 UWCCC 在为以下领域提供调查和研究设计支持方面拥有丰富的历史： 会员通过癌症预防和结果数据 (C-POD) SR；与 SHOW 合并为 支持整个 UWCCC 学区的癌症研究。在当前的 CCSG 周期中，C-POD 和 SHOW 为所有六个科学项目的 35 名独特的 UWCCC 成员提供服务。 SHOW 包括详细调查 体检数据描述了许多已确定的和新出现的癌症风险的人口趋势 因素，包括健康的多种社会决定因素。这些详细数据与存储的数据相结合 生物样本包括 4,000 多名威斯康星州居民的尿液、血清、血浆和 DNA。有了这个 作为独特的资源，SHOW 的目标是促进创新癌症研究，以改善癌症预防和治疗 控制威斯康星州所有社区。这是通过 3 个目标实现的：1) 加速癌症发生 通过使用现有数据进行监测和癌症预防和控制研究。展会 UWCCC 成员可以利用纵向数据进行病因学研究并监测患病率 UWCCC 学区已知和新出现的癌症风险因素。 2）促进新产品开发 利用 SHOW 专业知识和基础设施进行基于人群的癌症研究。独立于核心 SHOW数据，SHOW可以支持新的研究设计和调查开发，包括严格的和可重复的 基于人群的生物样本采集和储存的方法和协议。 3) 促进 SHOW 的使用 用于新型癌症研究的生物样本。 SHOW 拥有广泛的生物样本库和专业知识来支持 基于成本效益的生物标志物的癌症研究。 SHOW 教员领导 Malecki 博士（CPC）和 Schultz 博士， 设施经理，在人口基础方面拥有二十多年的综合经验和专业知识 流行病学、社区参与和转化研究。 SHOW也保持着悠久的历史 与为携带者服务的不同非裔美国人和农村社区组织的关系 最重的癌症负担。这些持续的伙伴关系对于 UWCCC 成员传播研究结果至关重要， 根据 UWCCC 战略计划推进癌症控制并减少差距。