Survey of the Health of Wisconsin

项目摘要/摘要 在美国，癌症仍然是导致死亡和残疾的主要原因，而且 城市和农村以及种族和民族人口都存在。人口健康科学是一门交叉学科 借鉴基础、临床和社会科学，确保翻译和传播新的 将知识转化为多个部门的有用应用程序。威斯康星州健康调查显示， 人口健康研究的长期基础设施。成立于2008年，展会包括正在进行的 代表整个威斯康星州的个人的纵向队列研究。作为一所威斯康星大学 骨癌中心(UWCCC)共享资源(SR)，SHOW为会员提供现有数据 收集基础设施和访问详细的调查数据、体检测量和生物检疫 推进癌症控制。UWCCC在提供调查和研究性研究设计支持方面有着丰富的历史 成员通过癌症预防和结果数据(C-POD)SR；该数据与SHOW合并为 支持整个UWCCC集水区的癌症研究。在当前的CCSG周期中，C-POD和 SHOW在所有六个科学项目中为35名独特的UWCCC成员提供服务。展览包括详细的调查 和体检数据，描述了许多公认的和新出现的癌症风险的人口趋势 影响健康的因素包括多种社会决定因素。这些详细数据与存储的 对超过4,000名威斯康星州居民进行了包括尿液、血清、血浆和DNA在内的生物样本检测。有了这个 独特的资源，SHOW的目标是促进创新的癌症研究，以改进癌症预防和 威斯康星州所有社区的控制权。这是通过三个目标实现的：1)加速癌症 利用现有数据进行监测和癌症预防与控制研究。节目中的 UWCCC成员可使用纵向数据进行病因学研究和监测患病率 UWCCC集水区的已知和新出现的癌症风险因素。2)促进新技术的发展 基于人口的癌症研究利用SHOW专业知识和基础设施。独立于核心 展示数据，展示可以支持新的研究设计和调查开发，包括严谨和可重复性 用于基于种群的生物样本收集和存储的方法和协议。3)培养对表演的使用 用于新型癌症研究的生物标记物。Show维护着广泛的生物资源库和专业知识，以支持 基于成本效益的生物标记物的癌症研究。马列基博士(CPC)、SHOW系主任和舒尔茨博士， 设施经理，在人口方面有20多年的综合经验和专业知识 流行病学、社区参与和转化性研究。展会也保持了悠久的历史 与不同的非裔美国人和农村社区组织的关系，这些组织为那些携带 最沉重的癌症负担。这些正在进行的伙伴关系对于UWCCC成员传播调查结果至关重要， 推进癌症控制，减少与UWCCC战略计划的差距。

PROJECT SUMMARY / ABSTRACT Cancer remains a leading cause of death and disability in the United States and significant disparities across urban and rural, as well as racial and ethnic populations, exist. Population health sciences is an interdisciplinary approach drawing on basic, clinical, and social sciences to ensure translation and dissemination of new knowledge into useful applications across multiple sectors. The Survey of the Health of Wisconsin, SHOW, is a long-standing infrastructure for population health research. Established in 2008, SHOW includes an ongoing longitudinal cohort study of individuals representing the entire state of Wisconsin. As a University of Wisconsin Carbone Cancer Center (UWCCC) shared resource (SR), SHOW provides members with an existing data collection infrastructure and access to detailed survey data, physical exam measurements and biospecimens for advancing cancer control. UWCCC has a rich history of providing survey and research study design support for members through the Cancer Prevention and Outcomes Data (C-POD) SR; which was merged with SHOW to support cancer research across the entire UWCCC catchment area. In the current CCSG cycle, the C-POD and SHOW served 35 unique UWCCC members across all six scientific programs. SHOW includes detailed survey and physical exam data describing population trends in numerous well established and emerging cancer risk factors including multiple social determinants of health. These detailed data are coupled with stored biospecimens including urine, serum, plasma and DNA on over 4,000 individual Wisconsin residents. With this unique resource, SHOW’s goal is to facilitate innovative cancer research for improved cancer prevention and control across all communities in Wisconsin. This is accomplished through 3 aims: 1) Accelerate Cancer Surveillance and Cancer Prevention and Control Research through the Use of Existing Data. SHOW’s longitudinal data are available to UWCCC members to conduct etiologic research and monitor the prevalence of known and emerging cancer risk factors across the UWCCC catchment. 2) Facilitate the Development of New Population Based Cancer Research Utilizing SHOW Expertise and Infrastructure. Independent of the core SHOW data, SHOW can support new study design and survey development, including rigorous and reproducible methods and protocols for population based biospecimen collection and storage. 3) Foster Use of SHOW Biospecimens for Novel Cancer Research. SHOW maintains an extensive biorepository and expertise to support cost effective biomarker based cancer research. Dr. Malecki (CPC), the SHOW Faculty Leader and Dr. Schultz, the Facility Manager, have over twenty years of combined experience and expertise in population based epidemiologic, community engaged, and translational research. SHOW also maintains long-standing relationships with diverse African American and rural community based organizations serving those carrying the heaviest cancer burden. These ongoing partnerships are critical for UWCCC members to disseminate findings, to advance cancer control and reduce disparities in alignment with the UWCCC Strategic Plan.