Super Resolution Ultrasound Imaging of Vasa Vasorum to Characterize the Progression of Atherosclerotic Plaques and Predict Rupture Vulnerability

血管超分辨率超声成像可表征动脉粥样硬化斑块的进展并预测破裂脆弱性

基本信息

  • 批准号:
    10557917
  • 负责人:
  • 金额:
    $ 75.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-02-01 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Acute coronary syndromes and strokes together constitute a leading cause of morbidity and mortality in the United States and Europe, approximately 80% of which are caused by atherosclerotic plaque (AP) rupture. Over the past decade, extensive efforts have been made to identify a rupture-prone AP. Among others, infiltration of dense neovascularization arising from vasa vasorum (VV) into the AP core plays a critical role in AP rupture. Postmortem studies revealed key involvement of VV in AP. However, a persistent lack of a noninvasive, high-resolution imaging tool to longitudinally assess abnormal microvascular expansion remains a critical barrier to adequate in-vivo investigation on how VV affects AP progression and contributes to eventual rupture. To address this dire unmet need, we propose an innovative transcutaneous super resolution ultrasound (SRU) imaging. The technology development in this project seeks to shift the current US imaging approach in identifying microvessels of AP from “intravascular” to a “fully noninvasive transcutaneous” imaging approach. This is only possible by achieving unprecedented high spatial resolution at large depth, breaking acoustic diffraction limit of the ultrasound frequency that governs spatial resolution. Our group has performed in-depth feasibility studies where SRU imaging successfully identified neomicrovessels in cholesterol-fed rabbit AP, evaluated against µCT and histology. Additionally, areas requiring further technical optimization were identified. Such technology developments and preliminary data thus far rigorously support our overarching hypothesis that enhanced and optimized SRU will accurately stage plaque progression and identify rupture- prone plaques by directly measuring VV changes with exquisite detail. To test the hypothesis, we will use a well-established, clinically relevant cholesterol-fed rabbit AP rupture model, which has shown the most similarity to human plaque pathology including VV neovascularization, to validate the novel SRU system to 1) Successfully quantify changes in vessel density and 2) Identify rupture-prone AP. To achieve these goals, we propose the following specific aims: 1) To develop enhanced SRU at high frequency using a commercial small animal imaging probe 2) To determine if VV changes estimated by SRU correlate with AP progression and are predictive of AP rupture. The immediate outcomes of the proposed work are an affordable noninvasive small animal SRU imaging tool and it’s validation on a clinically relevant rabbit AP model, which also can be used for other important small animal disease models, which are associated with microvessel abnormality such as cancer angiogenesis and kidney diseases to name a few. With proper adaptations into a clinical mid frequency probe and validation in clinical settings in future, this work will lead to our long-term translational goal to integrate SRU in a facile manner into the current clinical standard of carotid duplex sonography that has shown poor specificity to plaque vulnerability. This will help to effectively stratify patients at high risk of strokes and guide adequate intervention/treatment options for stroke prevention, exerting highly influential clinical impact.
项目总结

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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KANG KIM其他文献

KANG KIM的其他文献

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{{ truncateString('KANG KIM', 18)}}的其他基金

Development and Validation of a Multimodal Ultrasound- Based Biomarker for Myofascial Pain
基于多模态超声的肌筋膜疼痛生物标志物的开发和验证
  • 批准号:
    10579668
  • 财政年份:
    2022
  • 资助金额:
    $ 75.76万
  • 项目类别:
Super Resolution Ultrasound Imaging of Vasa Vasorum to Characterize the Progression of Atherosclerotic Plaques and Predict Rupture Vulnerability
血管超分辨率超声成像可表征动脉粥样硬化斑块的进展并预测破裂脆弱性
  • 批准号:
    10374343
  • 财政年份:
    2022
  • 资助金额:
    $ 75.76万
  • 项目类别:
Prevent Unnecessary Carotid Intervention and Stroke using Noninvasive Transcutaneous Ultrasound Thermal Strain Imaging (US-TSI)
使用无创经皮超声热应变成像 (US-TSI) 预防不必要的颈动脉干预和中风
  • 批准号:
    10192822
  • 财政年份:
    2020
  • 资助金额:
    $ 75.76万
  • 项目类别:
Prevent Unnecessary Carotid Intervention and Stroke using Noninvasive Transcutaneous Ultrasound Thermal Strain Imaging (US-TSI)
使用无创经皮超声热应变成像 (US-TSI) 预防不必要的颈动脉干预和中风
  • 批准号:
    10630204
  • 财政年份:
    2020
  • 资助金额:
    $ 75.76万
  • 项目类别:
Prevent Unnecessary Carotid Intervention and Stroke using Noninvasive Transcutaneous Ultrasound Thermal Strain Imaging (US-TSI)
使用无创经皮超声热应变成像 (US-TSI) 预防不必要的颈动脉干预和中风
  • 批准号:
    10414794
  • 财政年份:
    2020
  • 资助金额:
    $ 75.76万
  • 项目类别:
Advanced High Resolution Rodent Ultrasound Imaging System
先进的高分辨率啮齿动物超声成像系统
  • 批准号:
    9494245
  • 财政年份:
    2018
  • 资助金额:
    $ 75.76万
  • 项目类别:
Noninvasive fat quantification of liver using ultrasound thermal strain imaging
使用超声热应变成像对肝脏进行无创脂肪定量
  • 批准号:
    8638587
  • 财政年份:
    2014
  • 资助金额:
    $ 75.76万
  • 项目类别:
Noninvasive fat quantification of liver using ultrasound thermal strain imaging
使用超声热应变成像对肝脏进行无创脂肪定量
  • 批准号:
    8815309
  • 财政年份:
    2014
  • 资助金额:
    $ 75.76万
  • 项目类别:
Noninvasive Monitoring of Tissue-engineered Constructs by US Elasticity Imaging
通过美国弹性成像对组织工程构建体进行无创监测
  • 批准号:
    8242005
  • 财政年份:
    2011
  • 资助金额:
    $ 75.76万
  • 项目类别:
Noninvasive Monitoring of Tissue-engineered Constructs by US Elasticity Imaging
通过美国弹性成像对组织工程构建体进行无创监测
  • 批准号:
    8093116
  • 财政年份:
    2011
  • 资助金额:
    $ 75.76万
  • 项目类别:

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