Advanced High Resolution Rodent Ultrasound Imaging System

先进的高分辨率啮齿动物超声成像系统

• 批准号: 9494245
• 负责人: KANG KIM
• 金额: $ 39.01万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9494245
• 关键词: Advisory Committees; Animals; Biology; Biomedical Research; Blood Vessels; Cardiology; Cardiopulmonary; Cardiovascular system; Development; Discipline; Doctor of Philosophy; Echocardiography; Electrocardiogram; Environment; Experimental Animal Model; Experimental Models; Fostering; Frequencies; Funding; Future; Guidelines; Heart; Human Resources; Image; Institute of Medicine (U.S.); Institutes; Interdisciplinary Study; Laboratories; Lateral; Lung; Maintenance; Myocardial; Organ; Pulmonary Hypertension; Research; Research Personnel; Resolution; Resources; Rodent; Rodent Model; Scheme; Science; System; Technology; Three-Dimensional Imaging; Training; Ultrasonography; United States National Institutes of Health; Universities; animal imaging; contrast imaging; cost effectiveness; design; digital imaging; image registration; imaging platform; imaging system; innovation; instrument; multidisciplinary; programs; square foot; temporal measurement

This request is for funds to purchase a VisualSonics Vevo 3100 rodent ultrasound system. The objective of this proposal is to acquire this state-of-the-art high resolution advanced ultrasound imaging system to be shared by the multidisciplinary cardiovascular and cardiopulmonary investigators utilizing small animal experimental models at The University of Pittsburgh. An expansion of cardiovascular and pulmonary investigators from cardiology's Heart and Vascular Institute (HVI) merged with the Vascular Medicine Institute (VMI) has resulted in a high demand for imaging in a multitude of rodent experimental models. High-resolution ultrasound imaging has become the state-of-the-art for use in biomedical research, in particular for rodent models. The VisualSonics Vevo 3100 is the first and only commercially available high-frequency, high-resolution digital imaging platform with linear array technology capable of imaging live small animals. The ultra-high frequency axial and lateral resolution has an unprecedented 36x36 mm field of view. Furthermore, temporal resolution has dramatically increased to >500 Hz, of critical importance to imaging rodent hearts at 500-600 beats per min. This system has advanced new imaging functions including speckle tracking strain imaging, 3D imaging, ECG-gated image registration, and contrast imaging with harmonics. The system can assess whole organ scale functions to cellular level bioactivity. This system will be of enormous value to a wide spectrum of interdisciplinary research using rodent models. We have 13 independent PIs with active funding, 11 with NIH R01 equivalent support and 1 with AHA support. The participating PIs represent a wide array of disciplines in myocardial, vascular, cardiopulmonary biology and pulmonary hypertension. To promote cost effectiveness in maintenance and upgrades, optimize sharing, and foster a collaborative multidisciplinary environment, the system will be integrated into the VMI newly expanded laboratories, (now 15,800 sq. ft. of lab space). The Program Director, Kang Kim, PhD is an established innovator in advanced ultrasound technology and rodent ultrasound, and will take responsibility for the multiple facets of the instrument's use. An advisory committee has been formed with guidelines established for appropriate sharing among the users and by which new users can gain access to and training in the system. Our management scheme is designed for the optimal use of the system and maximum contribution to the listed projects and to continuously identify other NIH projects that will benefit from this system. The acquisition of the requested ultrasound animal imaging system will be of enormous value to not only to current NIH-funded projects across the University of Pittsburgh but also to the development of future NIH projects. In addition, echocardiography is a key focus of training and research the newly funded NIH T32 “Imaging Sciences in Translational Cardiovascular Research”. The University of Pittsburgh's VMI and HVI are fully committed to the support of maintenance, personnel, space, and resources required for long-term use of the system.

此请求旨在提供资金购买 VisualSonics Vevo 3100 啮齿动物超声系统。此举的目的 建议购买这种最先进的高分辨率先进超声成像系统，以便与 多学科心血管和心肺研究人员利用小动物实验 匹兹堡大学的模特。心血管和肺部研究人员的扩大 心脏病学的心脏和血管研究所 (HVI) 与血管医学研究所 (VMI) 合并 多种啮齿动物实验模型对成像的高需求。高分辨率超声成像 已成为生物医学研究中最先进的技术，特别是啮齿动物模型。这 VisualSonics Vevo 3100 是第一款也是唯一一款商用高频、高分辨率数字 采用线性阵列技术的成像平台，能够对活体小动物进行成像。超高频率 轴向和横向分辨率具有前所未有的 36x36 毫米视场。此外，时间分辨率 急剧增加到 >500 Hz，对于以 500-600 次跳动的啮齿动物心脏成像至关重要 分钟。该系统具有先进的新成像功能，包括散斑跟踪应变成像、3D成像、 心电图门控图像配准以及谐波对比成像。该系统可以评估整个器官 将函数缩放到细胞水平的生物活性。该系统将对广泛的领域具有巨大的价值 使用啮齿动物模型进行跨学科研究。我们有 13 名获得积极资助的独立 PI，其中 11 名来自 NIH R01 等效支持和 1 具有 AHA 支持。参与的 PI 代表了广泛的学科 心肌、血管、心肺生物学和肺动脉高压。促进成本效益 维护和升级，优化共享，并培育协作的多学科环境， 系统将集成到 VMI 新扩建的实验室（现实验室面积为 15,800 平方英尺）。这 项目总监 Kang Kim 博士是先进超声技术和啮齿动物领域的知名创新者 超声波，并将负责仪器使用的多个方面。咨询委员会 已经形成了为用户之间适当共享而制定的指导方针，新用户可以通过这些指导方针 可以访问该系统并接受培训。我们的管理计划旨在优化利用 系统和对所列项目的最大贡献，并不断确定其他 NIH 项目，这些项目将 受益于这个系统。所需超声动物成像系统的采购将是 不仅对匹兹堡大学当前 NIH 资助的项目具有巨大价值，而且对 NIH 未来项目的开发。此外，超声心动图是培训和研究的重点 新资助的 NIH T32“转化心血管研究中的成像科学”。大学 匹兹堡的 VMI 和 HVI 全力支持维护、人员、空间和资源 系统长期使用所需。