Allorecognition, parasitic stem cells and regeneration in a basal chordate
基底脊索动物的同种识别、寄生干细胞和再生
基本信息
- 批准号:10557096
- 负责人:
- 金额:$ 51.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AwardBiologicalBiological AssayBiological ModelsBlood VesselsBone Marrow TransplantationCardiovascular systemCellsChordataEndocrineEventFundingGerm cell tumorGoalsGrantGrowthHomingHumanImmunityImmunologyIndividualMediatingMolecularNatural regenerationNormal CellOrganismPeripheralPhenotypeProcessPropertyReactionRegenerative responseResearchResourcesSpecificityTransplantationWorkautocrinecancer cellcell regenerationfollow-upgermline stem cellsinnovationinsightnovelnovel strategiespreventprogramsresponse to injurystem cell biologystem cell nichestem cellstissue regenerationtransmission process
项目摘要
Abstract
Our lab works at the intersection of immunology, stem cell biology and regeneration, and the grants
funding this work (GM123267 and GM 123255) which we are requesting to merge in the MIRA program
have provided numerous insights into the molecular mechanisms underlying both self/non-self
recognition, as well as a genetically determined cell competition event that occurs between mobile
germline stem cells for niche occupancy. In addition, we have recently found that these same germline
stem cells, which are lineage restricted under normal conditions, are responsible for a regenerative
response to injury called Whole Body Regeneration, during which entire bodies, including all
cardiovascular, GI, central and peripheral nervous, endocrine and germline tissues are regenerated de
novo from isolated vascular fragments, and we propose to extend our research efforts into this robust
model system of chordate regeneration. As described in the proposal, in the last 18 months, these
studies have led to a number of exciting findings we will follow-up on during the upcoming funding
period, including: dissecting the molecular basis for allorecognition specificity and its conservation with
vertebrate immunity; a novel mechanism of autocrine stimulation that is required for homing of germline
stem cells and likely plays a role in the competitive phenotype; and rescue and lineage tracing assays
for whole body regeneration that have revealed that a single germline stem cell can give rise to an
entire body- a result which may have major implications for understanding germ cell tumors, and also
provides a unique opportunity for rapidly creating genetically modified lines of Botryllus. Our long-term
goals are to utilize the unique biological properties of Botryllus to carry out innovative molecular
mechanistic studies, and a MIRA award would allow us to redirect our efforts from funding to carrying
out more and better innovative research on these biomedically important topics.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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Anthony W De Tomaso其他文献
Anthony W De Tomaso的其他文献
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{{ truncateString('Anthony W De Tomaso', 18)}}的其他基金
Developing a new chordate model for stem cell biology and regeneration
开发用于干细胞生物学和再生的新脊索动物模型
- 批准号:
10373777 - 财政年份:2022
- 资助金额:
$ 51.41万 - 项目类别:
Developing a new chordate model for stem cell biology and regeneration
开发用于干细胞生物学和再生的新脊索动物模型
- 批准号:
10580589 - 财政年份:2022
- 资助金额:
$ 51.41万 - 项目类别:
Allorecognition, parasitic stem cells and regeneration in a basal chordate
基底脊索动物的同种识别、寄生干细胞和再生
- 批准号:
10322423 - 财政年份:2021
- 资助金额:
$ 51.41万 - 项目类别:
Cell competition and stem cell parasitism in a basal chordate
基底脊索动物的细胞竞争和干细胞寄生
- 批准号:
10017299 - 财政年份:2019
- 资助金额:
$ 51.41万 - 项目类别:
Molecular mechanisms of allorecognition in a basal chordate
基底脊索动物同种异体识别的分子机制
- 批准号:
9290237 - 财政年份:2017
- 资助金额:
$ 51.41万 - 项目类别:
Molecular mechanisms of allorecognition in a basal chordate
基底脊索动物同种异体识别的分子机制
- 批准号:
9433671 - 财政年份:2017
- 资助金额:
$ 51.41万 - 项目类别:
Cellular and gene regulatory mechanisms of whole body regeneration in Botryllus Schlosseri
灰霉病菌全身再生的细胞和基因调控机制
- 批准号:
9375865 - 财政年份:2017
- 资助金额:
$ 51.41万 - 项目类别:
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