The Synthesis of Bioactive Polycyclic Natural Products

描述（由申请人提供）：该研究计划的目标是发现和开发新的反应方法，以合成复杂的生物活性分子。我们提出的研究将集中在开发的方法，使许多生物活性，多环天然产物中普遍存在的核心结构和立体化学亚基的合成。我们开发的方法将在目前没有有效合成路线图的各种结构的合成中找到实用性。重要的是，本申请中提出的方法在本文所述的背景之外将是有用的，并且将用一组新的重要工具来武装合成化学的从业者（学术界、政府和工业界），以获得用于合成的关键构件。本授权申请中提出的研究集中在a）开发新的钯和铜催化的对映选择性烷基化和质子化反应，这些反应产生用于合成的重要构件，B）利用这些新方法合成稠环、螺环和桥环系统阵列，和c）在合成许多天然和非天然生物活性小分子中实施这些新工具。具体而言，我们概述了方法variecolin，przewalskin B，rocaglate木脂素，和communesin生物碱。这些分子从生物学的角度来看很重要，但也是我们新技术的试验场。作为这种方法的结果，我们将获得a）新颖的、医学上相关的结构，B）用于其合成的通用平台，以及c）将有益于许多不同应用的新合成方法。 公共卫生相关性：化学的核心在于以可预测和可靠的方式操纵元素以制备特定的原子阵列。作为合成化学家，我们以精密的精度构建分子的能力在科学界是独一无二的。在这份提案中，我们概述了一些新的方法，以建立重要的联系，并在高度复杂的情况下实施这些方法的相关人类医学。

DESCRIPTION (provided by applicant): The objective of this research program is to discover and develop new reaction methodology en route to the synthesis of complex bioactive molecules. Our proposed studies will focus on the development of methods that enable the synthesis of core structural and stereochemical subunits prevalent in many bioactive, polycyclic natural products. The processes that we develop will find utility in the synthesis of a variety of structures for which there is currently no efficient synthetic roadmap. Importantly, the methods presented in this application will be useful outside of the contexts described herein and will arm practitioners of synthetic chemistry (in academics, government, and industry) with a new set of important tools to access crucial building blocks for synthesis. The research proposed in this grant application is focused on a) the development of new palladium- and copper-catalyzed enantio-selective alkylation and protonation reactions that produce important building blocks for synthesis, b) the utilization of these novel methods for the synthesis of fused, spiro, and bridged ring system arrays, and c) the implementation of these new tools in the syntheses of numerous natural and non-natural bioactive small molecules. Specifically, we outline approaches to variecolin, przewalskin B, the rocaglate lignans, and the communesin alkaloids. These molecules are important from a biological standpoint, but also serve as a testing ground for our new technologies. As a consequence of this approach, we will have access to a) novel, medicinally relevant structures, b) a general platform for their synthesis, and c) new synthetic methodology that will benefit a host of diverse applications. PUBLIC HEALTH RELEVANCE: At the core of chemistry rests the power to manipulate the elements for the preparation of specific arrays of atoms in a predictable and reliable fashion. As synthetic chemists, our capacity to construct molecules with exquisite precision is unique in the sciences. In this proposal we outline a number of new approaches toward constructing important linkages and implementing these methods in highly complex situations of relevance to human medicine.