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Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk

几代人的情绪失调：识别早期发育和临床风险指标

基本信息

批准号：
10596133
负责人：
Liz D Conradt
金额：
$ 67.13万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-05 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10596133
关键词：
Adult Anxiety Arousal Articulation Attention deficit hyperactivity disorder Behavior Behavior assessment Behavioral Biological Biological Process Birth Caregivers Child Child Behavior Child Health Childhood Clinical Complex Data Development Developmental Process Diagnosis Diagnostic Diagnostics Research Disease susceptibility Distress Early Intervention Early identification Emotional Enrollment Exposure to Face Fetal Development Fetal Heart Rate Foundations Funding Generations Health Hour Infant Informal Social Control Intervention Laboratories Life Longitudinal Studies Maps Measures Mediating Mental Depression Mental Health Mental disorders Methods Mothers National Institute of Mental Health Newborn Infant Outcome Patient Self-Report Pattern Personal Satisfaction Personality Disorders Phenotype Physiological Physiology Postpartum Period Pregnancy Pregnant Women Problem behavior Procedures Process Psychiatric Diagnosis Psychopathology Psychophysiology Recovery Regulation Research Research Design Research Domain Criteria Risk Risk Factors Sampling Signal Transduction Social Processes Stress Testing Toddler Transact Uterus Woman Work clinically relevant cohort cost design dynamic system emotion dysregulation emotion regulation emotional distress ethnic diversity experience fetal flexibility heart rate variability improved in utero indexing infant outcome innovation intergenerational maternal risk maternal stress neurobehavior neurobehavioral novel prenatal prenatal exposure prenatal testing prevent programs psychiatric comorbidity psychologic recruit response social stress reactivity suicidal risk theories transmission process

项目摘要

PROJECT SUMMARY/ABSTRACT The developmental origins of psychopathology can be traced to in utero experiences. However, there is limited research into prenatal and newborn markers of early psychiatric problems. A promising line of inquiry suggests that exposure to maternal distress during pregnancy can have a lasting effect on child health and disease susceptibility. However, mechanisms associating maternal risk factors with child outcomes remain poorly understood. Emotion dysregulation (ED) is a transdiagnostic vulnerability factor that underlies many devastating and costly psychiatric diagnoses, including personality disorders, anxiety, depression, and suicide risk. Therefore, ED serves as a viable index of complex psychopathology among adults. In children, early signs of ED likely precede formal psychiatric diagnoses, such as anxiety, attention deficit/hyperactivity disorder, and difficulties with impulse or temper regulation. However, there have been few studies examining intergenerational transmission of ED or ED trajectories among mothers and their young children from an innovative Research Domain Criteria (RDoC) perspective. The objective of this proposal is to advance current understanding of ED across generations by (1) enrolling pregnant women with the full range of emotional distress, and (2) examining promising clinical and developmental indices of risk for psychopathology in their children. By adding to an existing, NIMH-funded cohort, the proposed study will follow N=324 mother-child dyads from pregnancy through 18 months, a developmental stage when child behavior problems begin to show rank- order stability. Consistent with the RDoC perspective, mothers will be recruited to meet a uniform distribution of ED scores and will complete a comprehensive prenatal laboratory battery to assess behavioral, psychophysiological, and self-reported measures of ED, stress, and psychopathology. Fetal physiological responses will also be recorded prenatally, as early indices of risk for ED. Within 24 hours of birth, babies will undergo a reliable and valid newborn neurobehavioral exam designed to detect emerging signs of dysregulation (e.g., high arousal and low self-regulation). At 7- and 18-months, mother-child pairs will return to the laboratory to engage in dyadic tasks that reliably elicit co-regulation and/or dysregulation. Behavioral and psychophysiological response patterns will be assessed in mother and child using dynamical systems methods that are appropriate for capturing complex developmental processes. This innovative and rigorously designed study unites a complex clinical sample with a well-established developmental design and advanced statistical approaches to better understand early mental health trajectories. When the aims of this project are realized, we will have an improved understanding of ED in mothers and their children during a critical stage that lays the building blocks for later health, development, and wellbeing. This longitudinal study will lay a foundation for research continuing into childhood and will advance a programmatic line of inquiry devoted to understanding dysregulated women and children to improve early intervention and prevent psychopathology.

项目总结/文摘