Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
批准号:
10405202
负责人:
Liz D Conradt
金额:
$17.56万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-09-01 至 2022-02-28
关键词:
AcousticsAdministrative SupplementAffectAwardBirthCaregiversCharacteristicsClinical MarkersComputer softwareComputerized Medical RecordComputersCryingData SetDevelopmentDevicesDiagnosisDiagnosticExposure toFundingGrantHairHealthHospitalizationHospitalsHourImpairmentInfantJudgmentLaboratoriesLength of StayManualsMeasurementMeasuresMorphineNational Institute of Drug AbuseNeonatal Abstinence SyndromeNeuraxisNewborn InfantNoiseNurseriesNursesNursing RecordsOpioidOutcomePharmacological TreatmentProceduresRecordsSamplingSeveritiesSoftware ToolsSubstance Withdrawal SyndromeSymptomsSystemTechnologyTelephoneTestingTimeTrainingUncertaintyUnited StatesWeaningWithdrawal SymptomWorkaccurate diagnosisapplication programming interfaceautomated analysisbaseclinical practicecloud basedcostdrug withdrawalfetal opioid exposuregastrointestinal systemimprovedinfant outcomemachine learning algorithmneurobehavioralneurodevelopmentopioid epidemicprenatalresearch clinical testingsociodemographic predictorssoftware systems
中文摘要
项目总结/文摘
英文摘要
PROJECT SUMMARY/ABSTRACT
This is an administrative supplement to our existing NIDA-funded grant entitled “Clinical markers of neonatal
opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome” (R01DA049755).
Every 15 minutes in the United States, an infant is born exposed to opioids, many of which develop the difficult
to treat drug withdrawal syndrome, Neonatal Opioid Withdrawal Syndrome (NOWS). Unfortunately, the diagnosis
of NOWS is highly subjective and includes “high pitched cry” simply based on the nurse’s judgement. The
objective measurement of the acoustic characteristics of the cry in babies with NOWS is a pivotal component of
the Specific Aims of the active award for this Administrative Supplement entitled “Clinical markers of neonatal
opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome” (R01DA049755):
Aim 1: Determine neurobehavioral, cry, prenatal opioid and other substance exposure measured via maternal
hair, and sociodemographic predictors of NOWS onset and severity.
Aim 2: Evaluate the predictive validity of these clinical markers and test whether NOWS severity predicts
neurodevelopment impairment at 6 and 18 months. We developed a computer-based cry analyzer that extracts
the acoustic features of an infant’s cry. We used the cry analyzer to determine the acoustic characteristics of the
cries of babies with NOWS and developed a NOWS cry “signature” that can identify which babies develop NOWS
with a 91% accuracy rate. However, the cry technology that we developed is not usable at the bedside. The
Specific Aim of this Administrative Supplement Is to develop a cloud-based system for the automated analysis
of infant cry acoustical characteristics for the diagnosis of NOWS. The proposed software will enable us to have
a fully automatic system, where a user records a baby cry in the newborn nursery using a phone or other
connected device, and within a few seconds, receives the diagnostic result. This Administrative Supplement will
provide the cloud-based software to change clinical practice by providing a more accurate and reliable diagnosis
of NOWS which will affect the pharmacological treatment of NOWS including length of hospital stay and
potentially improve the long-term outcome of these infants.
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专著(0)
科研奖励(0)
会议论文
Identifying risk earlier: Prenatal exposures, neurodevelopment, and infant sleep as pathways to toddler attention and behavior dysregulation
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批准号:10752879
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项目类别:
-
资助金额:$83.95万
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财政年份:2023
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负责人:Liz D Conradt
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依托单位:
Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
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批准号:10358574
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项目类别:
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资助金额:$77.33万
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财政年份:2020
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负责人:Liz D Conradt
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依托单位:
Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
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批准号:10589940
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项目类别:
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资助金额:$77.45万
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财政年份:2020
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负责人:Liz D Conradt
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依托单位:
Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk
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批准号:10851599
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项目类别:
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资助金额:$19.73万
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财政年份:2019
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负责人:Liz D Conradt
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依托单位:
Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk
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批准号:10596133
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项目类别:
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资助金额:$67.13万
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财政年份:2019
-
负责人:Liz D Conradt
-
依托单位:
Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk
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批准号:10380852
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项目类别:
-
资助金额:$70.38万
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财政年份:2019
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负责人:Liz D Conradt
-
依托单位:
The epigenetic basis of stress reacitvity: Implications for drug-exposed infants
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批准号:9326276
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项目类别:
-
资助金额:$14.89万
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财政年份:2014
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负责人:Liz D Conradt
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依托单位:
The epigenetic basis of stress reacitvity: Implications for drug-exposed infants
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批准号:8911396
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项目类别:
-
资助金额:$12.39万
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财政年份:2014
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负责人:Liz D Conradt
-
依托单位:
The epigenetic basis of stress reacitvity: Implications for drug-exposed infants
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批准号:9544136
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项目类别:
-
资助金额:$14.89万
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财政年份:2014
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负责人:Liz D Conradt
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依托单位:
The Impact of Prenatal Cocaine Exposure, Environmental Risk, and Trajectories
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批准号:8532873
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项目类别:
-
资助金额:$5.22万
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财政年份:2011
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负责人:Liz D Conradt
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依托单位:
The Impact of Prenatal Cocaine Exposure, Environmental Risk, and Trajectories
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批准号:8333546
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项目类别:
-
资助金额:$5.19万
-
财政年份:2011
-
负责人:Liz D Conradt
-
依托单位:
The Impact of Prenatal Cocaine Exposure, Environmental Risk, and Trajectories
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批准号:8198015
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项目类别:
-
资助金额:$4.9万
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财政年份:2011
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负责人:Liz D Conradt
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依托单位:
海外基金