Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
新生儿阿片戒断综合征的临床标志物:发病、严重程度和纵向神经发育结果
基本信息
- 批准号:10589940
- 负责人:
- 金额:$ 77.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AcousticsAddressAdultAffectAgeBirthCaregiversCharacteristicsChildChildhoodClinicalClinical MarkersCognitiveCollaborationsCryingDataDevelopmentDiagnosisDrug ExposureDrug abuseEnrollmentEnvironmentEpidemicExhibitsExposure toFollow-Up StudiesFunctional disorderFundingGoalsGovernmentHairHealthHospital ChargesHospitalizationHospitalsHourHyperactivityImpairmentIncidenceInfantInfant CareInterventionLanguage DevelopmentLength of StayLife StyleLongitudinal StudiesMeasuresMethodsModelingMotorNational Institute of Drug AbuseNeonatal Abstinence SyndromeNeurodevelopmental ImpairmentNewborn InfantOpioidOutcomeParticipantPathway interactionsPharmaceutical PreparationsPharmacological TreatmentPilot ProjectsPoliciesPregnancyPregnant WomenProtocols documentationPsyche structurePublishingRecording of previous eventsResourcesRhode IslandRiskRisk BehaviorsSeveritiesSex DifferencesSiteSleepStressSubstance Withdrawal SyndromeSymptomsTestingTimeTreatment ProtocolsTremorUnited StatesUnited States National Institutes of HealthUniversitiesUtahWomanclinical predictorscohortdesigndrug withdrawalevidence basefeedingfetal drug exposurefetal opioid exposurefetal substance exposurefollow up assessmentfollow-uphigh riskhuman subject protectionimprovedin utero diagnosisinfancyinsightinterestintergenerationalneurobehaviorneurobehavioralneurodevelopmentnovelopioid epidemicopioid exposureopioid usepersonalized medicinepharmacologicpostnatalpredictive markerpregnantprenatalprenatal exposureprescription opioidpreventprospectivepublic health emergencyrecruitreduce symptomsresearch clinical testingretention raterisk minimizationscreeningsocial health determinantssociodemographic predictorssociodemographicssocioeconomicsstandard of caresubstance usesuccesstooltransmission process
项目摘要
ABSTRACT
Every 20 minutes in the United States, a newborn is born exposed to opioids. Approximately 50-80% of these
newborns will develop Neonatal Opioid Withdrawal Syndrome (NOWS), characterized by autonomic instability,
hyperactivity, irritability, tremors, abnormal cry, and difficulty feeding and sleeping. Standard of care dictates
that these newborns should be placed on a 96-hour “hold” in the hospital for observation of NOWS. However,
this prolonged hospital stay can lead to both pharmacological and nonpharmacological treatment and even
longer hospitalization. For newborns that do develop NOWS, evidence suggests that non-pharmacological
interventions could reduce the symptoms of NOWS if intervention is implemented before symptoms of NOWS
are detected. The goal of this proposal is to test four novel, noninvasive clinical predictors of NOWS in
newborns and as markers of neurodevelopmental impairment at 6 and 18 months: Newborn neurobehavioral
assessments, newborn cry, prenatal substance exposure measured via maternal hair, and adverse
socioeconomic environments. We correctly identified 86.1% of newborns diagnosed with NOWS using our
NNNS and cry data in our pilot studies. If replicated, these findings could lead to personalized treatment
regimens and improved care for newborns. The identification of these factors could also provide insights into
the pathophysiology and clinical presentation of NOWS. We will conduct longitudinal neurodevelopmental
assessments at 6 and 18 months to determine whether these markers predict developmental impairment at
these ages. We will also examine whether a diagnosis of NOWS predicts neurodevelopmental impairment at 6
and 18 months. These data will provide clinicians and caregivers with valuable information about the extent to
which a NOWS diagnosis portends difficulties in cognitive, motor, or language development in infancy and
toddlerhood. We will enroll 312 newborns and their caregivers across two sites: Women and Infants Hospital of
Rhode Island and the University of Utah Hospital. Both sites have begun collecting pilot data and have
demonstrated success in recruiting 8 newborns/month. The MPIs have an almost 10-year history of
collaboration and have published over 20 articles together. In both sites they have established high recruitment
and retention rates. The scientific aims of this study are complimented and informed by a carefully designed
recruitment and retention plan, and protection of human subjects protocol intended to minimize risk to all
participants and provide appropriate resources to caregivers and newborns. When our aims are realized, we
will have generated novel and objective predictors of NOWS onset and severity, as well as
neurodevelopmental impairment at 6 and 18 months. This longitudinal study will establish a cohort of newborns
with prenatal opioid exposure that we plan to retain for long-term neurodevelopmental follow-up into childhood.
We also address one of the most pressing societal and health issues of our time, the opioid crisis, to generate
data that could lead to reductions in the severity of NOWS.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Liz D Conradt其他文献
Liz D Conradt的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Liz D Conradt', 18)}}的其他基金
Identifying risk earlier: Prenatal exposures, neurodevelopment, and infant sleep as pathways to toddler attention and behavior dysregulation
及早识别风险:产前暴露、神经发育和婴儿睡眠是导致幼儿注意力和行为失调的途径
- 批准号:
10752879 - 财政年份:2023
- 资助金额:
$ 77.45万 - 项目类别:
Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
新生儿阿片戒断综合征的临床标志物:发病、严重程度和纵向神经发育结果
- 批准号:
10405202 - 财政年份:2021
- 资助金额:
$ 77.45万 - 项目类别:
Clinical markers of neonatal opioid withdrawal syndrome: onset, severity and longitudinal neurodevelopmental outcome
新生儿阿片戒断综合征的临床标志物:发病、严重程度和纵向神经发育结果
- 批准号:
10358574 - 财政年份:2020
- 资助金额:
$ 77.45万 - 项目类别:
Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk
几代人的情绪失调:识别早期发育和临床风险指标
- 批准号:
10851599 - 财政年份:2019
- 资助金额:
$ 77.45万 - 项目类别:
Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk
几代人的情绪失调:识别早期发育和临床风险指标
- 批准号:
10596133 - 财政年份:2019
- 资助金额:
$ 77.45万 - 项目类别:
Emotion dysregulation across generations: Identifying early developmental and clinical indicators of risk
几代人的情绪失调:识别早期发育和临床风险指标
- 批准号:
10380852 - 财政年份:2019
- 资助金额:
$ 77.45万 - 项目类别:
The epigenetic basis of stress reacitvity: Implications for drug-exposed infants
应激反应性的表观遗传基础:对药物暴露婴儿的影响
- 批准号:
9326276 - 财政年份:2014
- 资助金额:
$ 77.45万 - 项目类别:
The epigenetic basis of stress reacitvity: Implications for drug-exposed infants
应激反应性的表观遗传基础:对药物暴露婴儿的影响
- 批准号:
8911396 - 财政年份:2014
- 资助金额:
$ 77.45万 - 项目类别:
The epigenetic basis of stress reacitvity: Implications for drug-exposed infants
应激反应性的表观遗传基础:对药物暴露婴儿的影响
- 批准号:
9544136 - 财政年份:2014
- 资助金额:
$ 77.45万 - 项目类别:
The Impact of Prenatal Cocaine Exposure, Environmental Risk, and Trajectories
产前可卡因接触的影响、环境风险和轨迹
- 批准号:
8532873 - 财政年份:2011
- 资助金额:
$ 77.45万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 77.45万 - 项目类别:
Research Grant