HLA-D AND T CELL RECEPTOR GENES IN HUMAN DISEASE

人类疾病中的 HLA-D 和 T 细胞受体基因

• 批准号: 6099685
• 负责人: J Donald Capra
• 金额: --
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1998-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6099685
• 关键词: Epstein Barr virus; MHC class II antigen; T cell receptor; antigenic peptide transporter; autoantigens; autoimmunity; cell transformation; diabetes mellitus genetics; genetic library; genetic polymorphism; histocompatibility gene; human population genetics; human subject; hybrid cells; insulin dependent diabetes mellitus; leukocyte activation /transformation; linkage mapping; lymphocyte; membrane transport proteins; molecular cloning; pancreatic islets; prediabetic state; rheumatoid arthritis; synovial membrane; transfection /expression vector

This project, which is submitted for its second competitive renewal, has been directed toward an understanding of disease susceptibility as it relates to HLA and T cell receptor genes. Here we extend these studies to a comprehensive analysis of the critical T cell target antigens in the two disease models we have studied to date: insulin dependent diabetes mellitus (IDDM) and rheumatoid arthritis (RA). Additionally, we will extend susceptibility studies to the peptide transporter genes with a focus on TAP-1. Finally, we will attempt to isolate peptides from MHC molecules in both disease models.

该项目已提交第二次竞赛 更新，旨在了解疾病 易感性与 HLA 和 T 细胞受体基因有关。这里 我们将这些研究扩展到对关键问题的全面分析 我们研究的两种疾病模型中的 T 细胞靶抗原 日期：胰岛素依赖型糖尿病 (IDDM) 和类风湿病 关节炎（RA）。此外，我们将扩大敏感性研究 肽转运蛋白基因，重点是 TAP-1。最后，我们 将尝试从两种疾病的 MHC 分子中分离肽 模型。