CT, MR AND CRYOMICROTOMIC STUDY OF SPINE ANATOMY

脊柱解剖学的 CT、MR 和冷冻显微切片研究

• 批准号: 2078931
• 负责人: VICTOR M HAUGHTON
• 金额: $ 20.75万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2078931
• 关键词: back injury; biomechanics; computed axial tomography; human tissue; magnetic resonance imaging; musculoskeletal disorder diagnosis; noninvasive diagnosis; spinal disk injury; spinal nerves

While 35 million Americans suffer from back pain, CT and MR are effective in diagnosing only a fraction of cases of back pain and sciatica. Painful conditions of the disc and facet joints, and some cases of central and lateral spinal stenosis are likely underdiagnosed by conventional CT, MR and radiographic studies. The aims of this project have been to improve the diagnostic usefulness of CT and MR by means of precise anatomic/tomographic correlations. The correlations have identified signs by which various defects in the anulus fibrous, nucleus pulposus, ligamentum flavum and facet joints can be demonstrated with tomographic imaging. The most valuable contribution of the work to date, according to previous reviews, was the use of biomechanical techniques to model the changes produced in the spinal canal and neural foramina by loads and stresses that may be produced by normal activities. The hypothesis of this study is that central and lateral spinal stenosis are underestimated in CT and MR because patients are recumbent during the acquisition of the images. We propose in the renewal to model extension, flexion, lateral bending and rotation of the spine in cadaveric specimens. Loads will be applied with biomechanical techniques to the spine to simulate movement of the spine, displacements will be measured with kinematic techniques, and changes in anatomic relationships of the discs, facet joints, ligamentum flavum, transforaminal ligaments, and nerve roots will be studied by means of CT, MR, and cryomicrotomy. The loads and displacements and anatomic situations which result in spinal stenosis will be identified. The study is likely to provide information on the causes of radiculopathy. Except in our studies of the spinal canal and neural foramen, the transforaminal ligaments, which reduce the space available for the spinal nerves, have been disregarded. Specifically, patho-anatomic changes in the neural foramina and spinal canal will be identified in which stresses such as upright position, weight bearing, and other activities may critically narrow the neural foramina or affect spinal nerves.

虽然 3500 万美国人患有背痛，但 CT 和 MR 有效 仅诊断一小部分背痛和坐骨神经痛病例。 椎间盘和小关节疼痛，以及某些情况 中央和侧方椎管狭窄很可能被低估 常规 CT、MR 和射线照相研究。 该项目的目标 提高 CT 和 MR 的诊断效能 精确的解剖/断层扫描相关性。 相关性有 识别纤维环、核的各种缺陷的迹象 髓、黄韧带和小关节可以通过以下方式展示 断层扫描成像。 迄今为止最有价值的工作贡献， 根据之前的评论，是利用生物力学技术 模拟椎管和神经孔产生的变化 正常活动可能产生的负载和压力。 这 本研究的假设是中央椎管狭窄和侧椎管狭窄 在 CT 和 MR 中被低估，因为患者在检查过程中是躺着的 图像的获取。 我们建议在更新模型扩展时， 尸体脊柱的屈曲、侧弯和旋转 标本。 将通过生物力学技术将负载施加到 脊柱 模拟脊柱的运动，将测量位移 随着运动学技术以及解剖学关系的变化 椎间盘、小关节、黄韧带、椎间孔韧带和 将通过 CT、MR 和冷冻切片术研究神经根。 这 导致脊柱的负载、位移和解剖情况 将识别狭窄。 该研究可能会提供信息 关于神经根病的原因。 除了我们对脊柱的研究 神经管和神经孔，椎间孔韧带，可减少 脊神经的可用空间已被忽略。 具体来说，神经孔和脊柱的病理解剖学变化 将确定运河中的应力，例如直立位置、 负重和其他活动可能会严重缩小神经 孔或影响脊神经。