T1,T2 AND PROTON DENSITY DETERMINED IN CEREBRAL PATHOLOG

提出了一种研究方法，首先研究了T1、T2和T2R的精度和精度 商用磁共振扫描仪上的质子密度测量由以下参数确定 体模研究，其次，在一系列的参数测量 对照组，即100名健康的各年龄段志愿者，以获得规范 数据。对照研究的另一个目标是评估 关于年龄、性别和体重的参数。下一阶段涉及 对几种特定类别的神经病理进行测量：(A)大脑 (B)原发性脑肿瘤(100例)；(C) 多发性硬化，包括星形细胞瘤、室管膜瘤、髓母细胞瘤、 脑膜瘤、听神经瘤(100例)。目标是 确定(1)脑缺血对T1或T2的影响是否 测量，(2)T1或T2松弛是否与肿瘤的组织学分级有关 星形细胞瘤，(3)如果T1或T2专用于任何类型的脑肿瘤， (4)如发现弥漫性T1、T2或质子密度异常 多发性硬化患者脑白质与离散斑块的区别 硬化症，(5)如果MS斑块有一个或多个特征 松弛参数的模式。

A study is proposed in which first the accuracy and precision of T1, T2 and proton density measurements on a commercial MR scanner are determined by phantom studies, and secondly, the parameters are measured in a series of controls, i.e. 100 healthy, volunteers of all ages to obtain normative data. An additional objective of the control studies is to evaluate the parameters with respect to age, sex, and weight. The next stage involves measurements for several specific classes of neuropathology: (a) cerebral ischemia (50 patients), (b) primary cerebral neoplasms (100 patients), (c) multiple sclerosis, including astrocytoma, ependymoma, medulloblastoma, meningioma, acoustic neuroma (100 patients). The objectives are to determine (1) if the effect of cerebral ischemia on T1 or T2 can be measured, (2) if T1 or T2 relaxation is related to the histologic grade of astrocytomas, (3) if T1 or T2 are specific for cerebral tumors of any type, (4) if diffuse T1, T2 or proton density abnormalities can be detected in the white matter distinct from discrete plaques in patients with multiple sclerosis, (5) if MS plaques have one or more than one characteristic pattern of relaxation parameters.