T1,T2 AND PROTON DENSITY DETERMINED IN CEREBRAL PATHOLOG

脑病理学中测定的 T1、T2 和质子密度

• 批准号: 3405719
• 负责人: VICTOR M HAUGHTON
• 金额: $ 12.47万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3405719
• 关键词: autoimmune disorder; body weight; brain neoplasms; cerebral ischemia /hypoxia; cerebrum; clinical biomedical equipment; gender difference; human age group; human subject; multiple sclerosis; myelinopathy; neoplasm /cancer chemotherapy; nervous system disorder chemotherapy; neuromuscular disorder chemotherapy; oxygen tension; proton beam; radiodiagnosis

A study is proposed in which first the accuracy and precision of T1, T2 and proton density measurements on a commercial MR scanner are determined by phantom studies, and secondly, the parameters are measured in a series of controls, i.e. 100 healthy, volunteers of all ages to obtain normative data. An additional objective of the control studies is to evaluate the parameters with respect to age, sex, and weight. The next stage involves measurements for several specific classes of neuropathology: (a) cerebral ischemia (50 patients), (b) primary cerebral neoplasms (100 patients), (c) multiple sclerosis, including astrocytoma, ependymoma, medulloblastoma, meningioma, acoustic neuroma (100 patients). The objectives are to determine (1) if the effect of cerebral ischemia on T1 or T2 can be measured, (2) if T1 or T2 relaxation is related to the histologic grade of astrocytomas, (3) if T1 or T2 are specific for cerebral tumors of any type, (4) if diffuse T1, T2 or proton density abnormalities can be detected in the white matter distinct from discrete plaques in patients with multiple sclerosis, (5) if MS plaques have one or more than one characteristic pattern of relaxation parameters.

提出了一项研究，其中首先对T1、T2和 在商用MR扫描仪上的质子密度测量通过以下步骤确定： 体模研究，其次，在一系列的测量参数， 对照组，即100名健康的所有年龄的志愿者，以获得标准的 数据 对照研究的另一个目的是评价 关于年龄、性别和体重的参数。 下一阶段涉及 测量几个特定类别的神经病理学：（a）脑 局部缺血（50名患者），（B）原发性脑肿瘤（100名患者），（c） 多发性硬化，包括星形细胞瘤，室管膜瘤，髓母细胞瘤， 脑膜瘤、听神经瘤（100例）。 其目标是 确定（1）脑缺血对T1或T2的影响是否可以 测量，（2）如果T1或T2弛豫与组织学分级相关， 星形细胞瘤，（3）如果T1或T2对任何类型的脑肿瘤具有特异性， (4)如果可以检测到弥漫性T1、T2或质子密度异常， 白色物质与多发性硬化患者的离散斑块不同， 硬化，（5）如果MS斑块具有一种或多种特征 松弛参数的模式。