A CT, MR AND CRYOMICROTOMIC STUDY OF SPINE ANATOMY

该项目的一个主要重点是提高 通过精确的解剖相关性解释脊柱MR和CT。 朝着第一个目标的进展，一个系统的相关性， 磁共振和CT图像与切片已在40种期刊上发表 文章描述了高分辨率轴向、冠状 和矢状面MR图像与冷冻切片。 重要 在实现第二个目标方面取得了进展： 正常发育和退行性变的CT和MR表现 脊柱内的变化。 最值得注意的和原始的 椎间盘内部结构的观察 已经在一系列论文中报道。 这些研究表明，正常的椎间盘退变是 其特征在于细胞核中胶原蛋白的逐渐增加， 纤维环和变性的特点是放射状撕裂， 纤维环，导致椎间盘膨出，椎间盘间隙 塌陷或髓核突出。 这些发现需要更多 study.第三个目的，研究脊柱解剖结构的变化， 当脊柱弯曲、伸展或加载时， 观察神经孔、椎间盘、脊柱 椎管作为脊柱受到各种负荷。 这项工作将 继续识别运动段的特征 （椎间盘），其中轴向载荷产生最大的 椎间盘或椎间孔尺寸改变，或产生更多压迫。 要求提供支持，以继续开展改进诊断的工作。 CT和MR的价值，并研究其挑衅性表现， 第一批补助金。 该项目的新重点是尖锐的 椎间盘的退行性变化，包括 纤维环放射状撕裂髓核突出 将研究1-49岁年龄组的尸体。 的 冷冻切片术和MR技术也将应用于急性 椎间盘退变，已经在狗身上模拟， 通过一个核切片机。 更精确的CT解释， 磁共振研究，改善神经压迫的放射学检测， 更好地选择患者进行传统和创新 治疗可以预见。

A major focus of this project has been improving the accuracy of interpretation of spine MR and CT by precise anatomic correlations. Progress toward the first objective, a systematic correlation of MR and CT images with sections has been documented in 40 journal articles describing correlations of high resolution axial, coronal and sagittal MR images with cryomicrotomic sections. Important progress has been made toward the second objective: to study the CT and MR appearance of normal developmental and degenerative changes within the spine. The most noteworthy and original observations, on the internal structure of the intervertebral disc visualized with MR, have been reported in a series of papers. These studies have suggested that normal disc degeneration is characterized by gradual increase in collagen in the nucleus and anulus and that degeneration is characterized by a radial tear of the anulus fibrosus, which leads to disc bulging, disc space collapse, or nucleus pulposus herniation. These findings need more study. The third objective, to study changes in spine anatomic relationships as the spine is flexed, extended or loaded, has produced observations in changes in neural foramina, discs, spinal canal as the spine is subjected to various loads. This work will be continued to identify the characteristics of motion segments (intervertebral discs) in which axial loading produces the greatest change in disc or foramen dimension, or produces more compression. Support is requested to continue work that improves the diagnostic value of CT and MR and to study the provocative findings of the first grant period. The new focus of the project is acute degenerative changes in the intervertebral disc including the radial tear of the anulus, herniation of the nucleus pulposus. Cadavers in the 1-49 year age group will be studied. The techniques of cryomicrotomy and MR will also be applied to acute intervertebral disc degeneration, which has been modelled in dogs, by means of a nucleotome. More precise interpretation of CT and MR studies, improved radiographic detection of nerve compression, and betters election of patients for conventional and innovative treatments can be anticipated.