Novel gene editing CRISPR Guided Vector technology to replace antibiotic use in farm animal production

“抗生素的过度使用导致耐药菌库的增加，导致人类死亡率增加（到2050年全球每年有1000万人死亡），住院时间延长（20-30天），估计全球直接和间接成本高达77万亿英镑。目前，没有新的抗生素正在开发中，替代品也无效。因此，随着耐药性进入人类食物链，全球动物生产面临着越来越大的减少抗生素使用的压力。然而，限制在农场预防和控制动物疾病的医疗干预措施的可用性直接影响到全球粮食安全和食品安全。因此，与目前的方法相比，对抗生素的有效替代治疗方法的需求尚未得到满足，这些方法简单，便宜且更具可持续性。该项目旨在开发一种新的基因编辑技术，针对一系列目前流行的细菌病原体，并提供100%的杀灭系统。这将使Folium与布里斯托尔大学和Quadram生物科学研究所合作，作为第一家将这种特定基因技术应用于牲畜治疗产品系列的公司，建立领先的市场地位。该项目的影响将通过提供现有治疗方法的替代方案，减少食品供应链中的抗生素耐药性，为畜牧业提供1.28亿英镑的初步成本节约，并有可能继续将这项技术转移到作物治疗应用、人类健康应用和制造清洁解决方案中。”

"Antibiotic overuse contributes to increasing the reservoir of resistant bacteria, resulting in increased human mortality (10million deaths a year globally by 2050), increased hospital stay lengths (20-30days), and estimates of global direct- and indirect- costs up to c.£77 trillion. Currently, no new antibiotics are under development and alternatives are ineffective. Consequently, animal production globally is under increasing pressure to reduce antibiotic use as resistance here enters the human food chain. However, limiting the availability of medical interventions to prevent and control animal disease on the farm is directly impacting global food security and food safety.Therefore, there is a major unmet need for effective alternative treatments to antibiotics which are simple, cheap and more sustainable compared to current methods. This project seeks to develop the use of a novel gene editing technology to target a range of currently prevalent bacterial pathogens and deliver a 100% killing system. This will enable Folium, in collaboration with the University of Bristol and the Quadram Institute of Bioscience to establish a leading market position as the first company to formulate this specific genetic technology in to a product range for livestock treatment. The impact of this project would provide an initial cost avoidance to the livestock industry of c.£128million by offering an alternative to current treatment methods and reducing antibiotic resistance in the food supply chain, with potential to go on and transfer this technology to crop treatment applications, human health applications and manufacturing cleaning solutions."