Novel gene editing CRISPR Guided Vector technology to replace antibiotic use in farm animal production

“抗生素的过度使用导致耐药细菌的储存增加，导致人类死亡率增加（到2050年全球每年有1000万人死亡），住院时间延长（20- 30天），估计全球直接和间接成本高达约77万亿英镑。目前，没有新的抗生素正在开发中，替代品无效。因此，随着耐药性进入人类食物链，全球动物生产面临越来越大的压力，需要减少抗生素的使用。然而，限制用于预防和控制农场动物疾病的医疗干预措施的可用性直接影响到全球粮食安全和食品安全，因此，与现有方法相比，对简单、廉价和更可持续的抗生素有效替代治疗的需求尚未得到满足。该项目旨在开发一种新型基因编辑技术的用途，以针对一系列目前流行的细菌病原体，并提供100%的杀灭系统。这将使生物技术公司与布里斯托大学和Quadram生物科学研究所合作，成为第一家将这种特定基因技术应用于牲畜处理产品系列的公司，从而确立领先的市场地位。该项目的影响将为畜牧业提供约1.28亿英镑的初始成本，通过提供现有处理方法的替代方案并减少食品供应链中的抗生素耐药性，并有可能继续将该技术转移到作物处理应用，人类健康应用和制造清洁解决方案。"

"Antibiotic overuse contributes to increasing the reservoir of resistant bacteria, resulting in increased human mortality (10million deaths a year globally by 2050), increased hospital stay lengths (20-30days), and estimates of global direct- and indirect- costs up to c.£77 trillion. Currently, no new antibiotics are under development and alternatives are ineffective. Consequently, animal production globally is under increasing pressure to reduce antibiotic use as resistance here enters the human food chain. However, limiting the availability of medical interventions to prevent and control animal disease on the farm is directly impacting global food security and food safety.Therefore, there is a major unmet need for effective alternative treatments to antibiotics which are simple, cheap and more sustainable compared to current methods. This project seeks to develop the use of a novel gene editing technology to target a range of currently prevalent bacterial pathogens and deliver a 100% killing system. This will enable Folium, in collaboration with the University of Bristol and the Quadram Institute of Bioscience to establish a leading market position as the first company to formulate this specific genetic technology in to a product range for livestock treatment. The impact of this project would provide an initial cost avoidance to the livestock industry of c.£128million by offering an alternative to current treatment methods and reducing antibiotic resistance in the food supply chain, with potential to go on and transfer this technology to crop treatment applications, human health applications and manufacturing cleaning solutions."