EPIDEMIOLOGIC STUDY OF LUNG CANCER AND WOOD DUST

肺癌和木尘的流行病学研究

• 批准号: 2095306
• 负责人: THOMAS L VAUGHAN
• 金额: $ 38.73万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2095306
• 关键词: adult human (21+); ascorbate; cancer risk; carotene; diet; dust; family genetics; human subject; industry; interview; lung neoplasms; male; neoplasm /cancer epidemiology; nutrition related tag; occupational hazard; questionnaires; statistics /biometry; tobacco abuse

A population-based case-control study of lung cancer is proposed to determine if employment in wood-related occupations is associated with increased risk of lung cancer, and to identify specific exposures in these jobs which might explain any increased risks found. Specifically, we will: a) test the hypothesis that persons employed in operational jobs in any of the four major segments of the wood industry are at increased risk of lung cancer; b) test the hypothesis that persons exposed to respirable wood dust in particular, as well as several other potential carcinogens present in wood-related occupations, are at increased risk of lung cancer; and c) determine whether excess risk associated with any of the above factors varies by histologic type, or is modified by other known risk factors such as tobacco use, dietary intake of beta-carotene and vitamin C, or family history of lung cancer. Male cases aged 18-74 years who reside in an 11-county area of western Washington where wood-related occupations are particularly common will be identified from the Cancer Surveillance System of the Fred Hutchinson Cancer Research Center (a SEER registry). Controls of similar age from the same geographic area will be selected by random digit dialing. Approximately 769 cases and an equal number of controls will be interviewed over a three-year period. Subjects will be interviewed by telephone using a structured questionnaire and experienced interviewers. A standard mailed self-administered questionnaire will be used to collect limited dietary information. Exposure to wood dust will be assessed on an individual basis by two industrial hygienists, taking into account job title and typical duties, type of manufactured product, and participation in activities known to produce measurable concentrations of respirable dust. For industries in western Washington in which total and respirable dust levels are not well-characterized, random full-shift sampling will also be accomplished during the first year. Approximately 680 samples will be taken at a minimum of eight industrial sites over two seasons. Stratified analysis and logistic regression will be used to control for the effect of major risk factors and to identify any important effect modification by these factors. Polytomous logistic regression will be used along with pairwise logistic regression to investigate differences in risk among specific histologic types of lung cancer. It is estimated that if wood dust is etiologically related to lung cancer, it may account for 15% of male lung cancer cases in parts of western Washington and 3% nationwide. This would represent approximately 3,000 cases per year in the United States.

建议开展一项基于人群的肺癌病例对照研究 确定木材相关职业的就业是否与 增加患肺癌的风险，并确定这些物质的具体暴露情况 可能解释所发现风险增加的工作。 具体来说，我们将： a) 检验以下假设：从事运营工作的人员 木材工业的四个主要部门面临更高的肺癌风险 癌症; b) 检验暴露于可吸入木屑的人员的假设 特别是，以及存在于其中的其他几种潜在致癌物质 与木材相关的职业，患肺癌的风险增加；和c) 确定超额风险是否与上述任何因素相关 因组织学类型而异，或被其他已知的危险因素改变，例如 如吸烟、饮食中摄入 β-胡萝卜素和维生素 C，或家庭 有肺癌病史。 男性病例，年龄 18-74 岁，居住在 华盛顿州西部 11 个与木材相关的职业较多的县 癌症监测系统将识别出特别常见的 Fred Hutchinson 癌症研究中心（SEER 注册中心）的成员。 控制 来自同一地理区域的相似年龄的人将被随机选择 数字拨号。 大约 769 例病例和同等数量的对照 将接受为期三年的采访。 受试者将接受采访 通过电话，使用结构化问卷和经验丰富的访谈员。 将使用标准的邮寄自填问卷来收集 有限的饮食信息。 暴露于木尘的情况将根据 由两名工业卫生员根据个人情况，考虑到工作 头衔和典型职责、制造产品的类型以及参与 在已知会产生可测量浓度的可吸入污染物的活动中 灰尘。 对于华盛顿州西部的工业，其中总的和可吸入的 粉尘水平没有得到很好的表征，随机全班次抽样将 也可以在第一年完成。 大约 680 个样本将 两个季节至少在八个工业场地进行采集。 分层分析和逻辑回归将用于控制 主要风险因素的影响并确定任何重要影响 这些因素的修改。 将使用多分逻辑回归 与成对逻辑回归一起研究风险差异 肺癌的特定组织学类型。 估计如果 木屑与肺癌病因有关，可能占15% 华盛顿州西部部分地区男性肺癌病例占 3%，全国男性肺癌病例占 3%。 这意味着美国每年大约有 3,000 例病例 国家。