ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROL

设立癌症预防和控制领域的研究者奖

• 批准号: 8522164
• 负责人: THOMAS L VAUGHAN
• 金额: $ 15.12万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-23 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8522164
• 关键词: Address; Americas; Anthropometry; Applications Grants; Award; Barrett Esophagus; Barrett' s Adenocarcinoma; Biological Markers; Biology; Biometry; Blood; Calibration; Cancer Control; Caring; Chromosomal Instability; Clinical; Commit; Counseling; Country; Data; Data Set; Development; Discipline; Disease; Education; Educational workshop; Ensure; Environmental Risk Factor; Epidemiology; Esophageal Adenocarcinoma; Etiology; Evaluation; Faculty; Fred Hutchinson Cancer Research Center; Funding; Gap Junctions; Gastroenterology; General Population; Genetic; Genome; Grant; Health Personnel; Health Policy; Incidence; Individual; Inflammation; Institutes; Institution; International; Joints; Journals; Knowledge; Leadership; Length; Malignant Neoplasms; Manuscripts; Measures; Medical Research; Mentors; Modeling; Molecular Biology; National Institute of Diabetes and Digestive and Kidney Diseases; Oxidative Stress; Paper; Participant; Patient Education; Pharmaceutical Preparations; Phase; Physiology; Policy Developments; Population; Population Attributable Risks; Population Genetics; Population Heterogeneity; Postdoctoral Fellow; Prevention; Prevention program; Preventive Intervention; Primary Health Care; Provider; Publishing; Queensland; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Running; Secondary to; Senior Scientist Award; Site; Societies; Students; Supervision; Target Populations; Time; Tissues; Training; Trust; Universities; Validation; Visit; Washington; Work; adipokines; anticancer research; base; cancer epidemiology; cancer prevention; clinical decision-making; cost effectiveness; design; directed evolution; experience; genetic epidemiology; genome wide association study; genome-wide; graduate student; insulin sensitivity; interest; lectures; male; meetings; member; population health; pre-doctoral; programs; response; skills; symposium; telomere; tool; tumor progression; wasting

DESCRIPTION (provided by applicant): The K05 award will provide Dr. Thomas L Vaughan with protected time (30% FTE) to continue to pursue key research questions related to the etiology and prevention of esophageal adenocarcinoma (EA), a cancer that has undergone a remarkable increase in incidence (6-fold overall, and 10-fold among white males) in the US and many western countries during the past four decades. It will also provide for protected time (20% FTE) to continue his extensive mentoring activities of students, postdoctoral fellows and junior investigators at the University of Washington (UW), the Fred Hutchinson Cancer Research Center (FHCRC) and outside institutions. The first four years of his current award (July 2007 - October 2011) provided critical protected time for him to focus on further developing and strengthening his research program on EA. Aim 1 of the current award funds his effort on analyses of previously-collected data and biospecimens from local studies with expired funding. This concentrated effort has thus far resulted in 20 published papers, and eight submitted manuscripts, many involving his direct supervision of pre- and postdoctoral mentees. Dr. Vaughan was one of the co-founders of the international Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) in 2005, supported in part by NCI. He was elected as first Steering Committee Chair and continues in that role. Aim 2 of the current award involves establishing BEACON as an important nexus for research on etiology and prevention of EA. During the first four years of the current award, membership in the consortium has approximately doubled, with annual workshops typically involving 40-50 attendees. Additional expertise in clinical gastroenterology, molecular biology, physiology, genetics, evolutionary biology and population genetics has been added to significantly expand the range of expert skill and knowledge available to plan and carry out new studies. Six research projects have been by grants from the NCI, NIDDK, Cancer Research UK, and the Swedish Cancer Society. Over the past two years, a further six manuscripts have been published or submitted and several more are in the final phases of development. Aim 3 of the current award involves development of new collaborative research projects within BEACON. The award allowed Dr. Vaughan to develop a multiple PI grant (funded in late 2009) for a genome-wide association study involving 14 sites and about 8,500 participants. The K05 award was key in providing not only protected time to develop this logistically-complicated grant application, but important training opportunities for Dr. Vaughan in genetic epidemiology (e.g., Welcome Trust conference on genetics of common diseases; invited participation at the Illumina Americas Scientific Summit and as a visiting scholar at Queensland Institute of Medical Research.) Proposed research activities during the renewal period represent a direct evolution of ideas and projects developed during the current K05 award period. The first aim will utilize the rich data resources of BEACON to develop risk and prediction models which are tailored to the absolute risk of specific populations that will be useful for a) health policy development, b) education, c) clinical decision-making, and d) designing future research. This aims address critical barriers to EA control by facilitating improvement in the costs and effectiveness of EA prevention interventions by ensuring that they make optimum use of knowledge regarding risk factors, protective factors and biomarkers that predict neoplastic progression, response to therapy and survival. The second aim encompasses his continued scientific leadership role in BEACON. Specifically this involves developing and actively participating in ongoing and new pooled analyses with the Consortium members, including ongoing BEACON studies such as analysis of telomere length, IGF-related markers, and adipokines; as well as ancillary analyses to the ongoing genome-wide association study of BE and EA. It also involves developing new collaborative research projects with BEACON investigators and mentees that will take advantage of the diverse populations represented, along with existing banks of well-characterized tissues. Dr. Vaughan has a well-established track record of mentoring graduate students and postdoctoral fellows, as well as junior faculty in Epidemiology and related disciplines. He is Director of an NCI-funded Cancer Epidemiology and Biostatistics Training Grant which funds nine predoctoral and four postdoctoral trainees and runs the journal club. He guest lectures in established epidemiology courses, and has served on 29 master's thesis committees, and 26 doctoral dissertation committees. Mentoring activities funded by the K05 will include: i) those associated with his responsibilities on the training grant, ii) his ongoing mentoring of other trainees from Epidemiology and related departments, and iii) mentoring junior faculty at the UW, FHCRC and outside institutions. Each year, he plans to work closely with two to three predoctoral students, one to two postdoctoral fellows; and one to two junior faculty members.

描述（由申请人提供）：K05奖将为托马斯·沃恩博士提供受保护的时间（30％FTE），以继续追求与食管腺癌的病因学和预防相关的关键研究问题，该癌症是一种癌症，该癌症是一种出色的率增加了（6倍整体上的白人马尔斯），并且在我们的许多西方国家中，我们在我们中的几个国家中有了10倍的范围，并且在我们的许多国家中，我们的许多西方国家都在我们和许多西方国家中的癌症。它还将提供受保护的时间（20％FTE），以继续他的广泛指导活动，华盛顿大学（UW），弗雷德·哈钦森癌症研究中心（FHCRC）和外部机构的广泛指导活动。 他目前奖项的前四年（2007年7月至2011年10月）为他提供了关键的时间，让他专注于进一步发展和加强他对EA的研究计划。目前的AIM 1资助了他在本地研究中对以前收集的数据和生物质量分析的努力，并提供了过期资金。迄今为止，这项集中的努力导致了20篇发表的论文，并提交了8份手稿，其中许多涉及他对学前和博士后受训者的直接监督。沃恩博士是国际巴雷特和食管腺癌财团（Beacon）（Beacon）的共同创始人之一，部分由NCI支持。他当选为第一指导委员会主席，并继续担任该职务。目前奖项的目标2涉及建立信标成为EA的病因和预防研究的重要联系。在当前奖项的前四年中，该财团的会员资格大约翻了一番，年度研讨会通常涉及40-50名与会者。已经添加了临床胃肠病学，分子生物学，生理学，遗传学，进化生物学和种群遗传学方面的其他专业知识，以显着扩大可用于计划和进行新研究的专家技能和知识范围。 NCI，NIDDK，UK Cancer Research和瑞典癌症协会的赠款已获得了六项研究项目。在过去的两年中，另外有六本手稿被出版或提交，并且还有更多手稿在开发的最后阶段。当前奖项的目标3涉及制定信标内的新合作研究项目。该奖项使沃恩博士能够为全基因组协会研究开发多个PI赠款（于2009年底资助），其中涉及14个站点和约8,500名参与者。 K05奖是为不仅提供了开发这种逻辑上复杂的赠款应用程序的保护时间的关键，而且还为沃恩博士提供了遗传流行病学的重要培训机会（例如，普通疾病遗传学的欢迎信托基金会；邀请参与Illumina Americas Scientific Sc​​ientific Sc​​ientific Sc​​ientific Sc​​ientific峰会和作为QueSensland Queeensland医疗研究所的来访学者）。 续签期间提出的研究活动代表了当前K05奖励期间开发的思想和项目的直接发展。第一个目标将利用信标的丰富数据资源来开发风险和预测模型，这些模型是针对特定人群的绝对风险量身定制的，这些风险将对a）卫生政策制定有用，b）教育，c） 临床决策和d）设计未来的研究。通过促进EA预防干预措施的成本和有效性，通过确保他们最佳利用有关风险因素，保护因素和生物标志物来预测肿瘤进展，对治疗和生存的反应和生存的知识，这是针对EA控制的关键障碍。第二个目标涵盖了他在Beacon中持续的科学领导角色。具体而言，这涉及与财团成员进行正在进行的和新的合并分析，包括正在进行的信标研究，例如对端粒长度，与IGF相关的标记和脂肪因子的分析；以及对BE和EA的持续基因组关联研究的辅助分析。它还涉及与信标研究人员和受训者一起开发新的合作研究项目，这些研究将利用代表的不同人群，以及现有的特征良好的组织。 沃恩博士在指导研究生和博士后研究员以及流行病学和相关学科的初级教职员工方面拥有良好的记录。他是NCI资助的癌症流行病学和生物统计学培训补助金的董事，该培训资助了9个祖先和4名博士后学员，并经营期刊俱乐部。他在既定的流行病学课程中的嘉宾演讲，并曾在29个硕士论文委员会和26个博士学位论文委员会任职。由K05资助的指导活动将包括：i）与他在培训补助金上的责任相关的那些，ii）他正在进行的流行病学和相关部门的其他学员的持续指导，以及iii）在UW，FHCRC和外部机构中指导初级教师。每年，他都计划与两到三个学生，一到两个博士后研究员紧密合作；以及一到两个初级教师。