Established Investigator Award in Cancer Prevention and Control

描述（由申请人提供）：K05奖将为Thomas L Vaughan博士提供受保护的时间（30% FTE），以追求与食管腺癌的病因和预防相关的关键研究问题，这种癌症的发病率在30年内增加了6倍以上。此外，他还将提供受保护的时间（20%的全职工作时间），以扩大他对华盛顿大学（UW）和弗雷德哈钦森癌症研究中心（FHCRC）学生和其他初级研究人员的广泛指导活动。他是巴雷特和食管腺癌联盟（BEACON）的创始人之一，这是一个由30多名研究人员组成的国际联盟，代表16项研究，部分由NCI和NIDDK支持，并当选为指导委员会的首任主席。该奖项的研究方面将在BEACON的背景下进行，包括：i)继续分析收集的数据和组织，这些数据和组织是基于社区的巴雷特事件病例对照研究的一部分，Vaughan博士是该事件的PI； ii)对BEACON调查人员开展的多个基于人群的研究数据进行汇总分析；iii)在BEACON内部开发新的合作研究项目，利用所代表的不同人群和现有的特征良好的组织库。沃恩博士在指导研究生和博士后以及流行病学和相关学科的初级教师方面有着良好的记录。1990-2006年，他是环境流行病学培训基金的联合主任；2005年，他担任nci资助的癌症流行病学和生物统计学培训基金（T32CA09168）的主任。他经常担任流行病学课程的客座讲师，曾在23个硕士论文委员会和20个博士论文委员会任职。K05项目的扩展指导活动将包括：i)与培训资助相关的指导活动，ii)他对来自流行病学和相关部门的其他受训者的持续指导，以及华盛顿大学和FHCRC公共卫生学科的初级教师，以及iii)两名新的博士生或博士后直接参与K05相关的研究活动。

DESCRIPTION (provided by applicant): The K05 award will provide Dr. Thomas L Vaughan with protected time (30% FTE) to pursue key research questions related to the etiology and prevention of esophageal adenocarcinoma, a cancer that has increased over six-fold in incidence over three decades. It will also provide for protected time (20% FTE) to expand his already extensive mentoring activities of students and other junior investigators at the University of Washington (UW) and the Fred Hutchinson Cancer Research Center (FHCRC). Dr. Vaughan was one of the founders of the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON), an international consortium of over 30 investigators representing 16 studies, supported in part by NCI and NIDDK, and was elected as the first Chair of the Steering Committee. The research aspects of this award will be conducted in the context of the BEACON, and consist of: i) continued analyses of data and tissue collected as part of a community-based case-control studies of incident Barrett's for which Dr. Vaughan was PI, ii) pooled analyses of data from multiple population-based studies carried out by BEACON investigators, and iii) development of new collaborative research projects within BEACON that take advantage of the diverse populations represented, and existing banks of well-characterized tissues. Dr. Vaughan has a well-established track record of mentoring graduate students and postdoctoral fellows, as well as junior faculty in Epidemiology and related disciplines. He was Co-director of the Environmental Epidemiology Training Grant from 1990-2006; in 2005 he assumed responsibility as Director of the NCI-funded Cancer Epidemiology and Biostatistics Training Grant (T32CA09168). He is a frequent guest lecturer in established epidemiology courses, and has served on 23 masters thesis committees and 20 doctoral dissertation committees. Expanded mentoring activities on the K05 will include: i) those associated with his responsibilities on the training grant, ii) his ongoing mentoring of other trainees from Epidemiology and related departments, and junior faculty across public health disciplines at the UW and FHCRC, and iii) two new pre- or post-doctoral students working directly on K05-associated research activities.