ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROL

设立癌症预防和控制领域的研究者奖

• 批准号: 8702923
• 负责人: THOMAS L VAUGHAN
• 金额: $ 15.12万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-23 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702923
• 关键词: Address; Americas; Anthropometry; Applications Grants; Award; Barrett Esophagus; Barrett' s Adenocarcinoma; Biological Markers; Biology; Biometry; Blood; Calibration; Cancer Control; Caring; Chromosomal Instability; Clinical; Commit; Counseling; Country; Data; Data Set; Development; Discipline; Disease; Education; Educational workshop; Ensure; Environmental Risk Factor; Epidemiology; Esophageal Adenocarcinoma; Etiology; Evaluation; Faculty; Fred Hutchinson Cancer Research Center; Funding; Gap Junctions; Gastroenterology; General Population; Genetic; Genome; Grant; Health Personnel; Health Policy; Incidence; Individual; Inflammation; Institutes; Institution; International; Joints; Journals; Knowledge; Leadership; Length; Malignant Neoplasms; Manuscripts; Measures; Medical Research; Mentors; Modeling; Molecular Biology; National Institute of Diabetes and Digestive and Kidney Diseases; Oxidative Stress; Paper; Participant; Patient Education; Pharmaceutical Preparations; Phase; Physiology; Policy Developments; Population; Population Attributable Risks; Population Genetics; Population Heterogeneity; Postdoctoral Fellow; Prevention; Prevention program; Preventive Intervention; Primary Health Care; Provider; Publishing; Queensland; Research; Research Activity; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Running; Secondary to; Senior Scientist Award; Site; Societies; Students; Supervision; Target Populations; Time; Tissues; Training; Trust; Universities; Validation; Visit; Washington; Work; adipokines; anticancer research; base; cancer epidemiology; cancer prevention; clinical decision-making; cost effectiveness; design; directed evolution; experience; genetic epidemiology; genome wide association study; genome-wide; graduate student; insulin sensitivity; interest; lectures; male; meetings; member; population health; pre-doctoral; programs; response; skills; symposium; telomere; tool; tumor progression; wasting

DESCRIPTION (provided by applicant): The K05 award will provide Dr. Thomas L Vaughan with protected time (30% FTE) to continue to pursue key research questions related to the etiology and prevention of esophageal adenocarcinoma (EA), a cancer that has undergone a remarkable increase in incidence (6-fold overall, and 10-fold among white males) in the US and many western countries during the past four decades. It will also provide for protected time (20% FTE) to continue his extensive mentoring activities of students, postdoctoral fellows and junior investigators at the University of Washington (UW), the Fred Hutchinson Cancer Research Center (FHCRC) and outside institutions. The first four years of his current award (July 2007 - October 2011) provided critical protected time for him to focus on further developing and strengthening his research program on EA. Aim 1 of the current award funds his effort on analyses of previously-collected data and biospecimens from local studies with expired funding. This concentrated effort has thus far resulted in 20 published papers, and eight submitted manuscripts, many involving his direct supervision of pre- and postdoctoral mentees. Dr. Vaughan was one of the co-founders of the international Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) in 2005, supported in part by NCI. He was elected as first Steering Committee Chair and continues in that role. Aim 2 of the current award involves establishing BEACON as an important nexus for research on etiology and prevention of EA. During the first four years of the current award, membership in the consortium has approximately doubled, with annual workshops typically involving 40-50 attendees. Additional expertise in clinical gastroenterology, molecular biology, physiology, genetics, evolutionary biology and population genetics has been added to significantly expand the range of expert skill and knowledge available to plan and carry out new studies. Six research projects have been by grants from the NCI, NIDDK, Cancer Research UK, and the Swedish Cancer Society. Over the past two years, a further six manuscripts have been published or submitted and several more are in the final phases of development. Aim 3 of the current award involves development of new collaborative research projects within BEACON. The award allowed Dr. Vaughan to develop a multiple PI grant (funded in late 2009) for a genome-wide association study involving 14 sites and about 8,500 participants. The K05 award was key in providing not only protected time to develop this logistically-complicated grant application, but important training opportunities for Dr. Vaughan in genetic epidemiology (e.g., Welcome Trust conference on genetics of common diseases; invited participation at the Illumina Americas Scientific Summit and as a visiting scholar at Queensland Institute of Medical Research.) Proposed research activities during the renewal period represent a direct evolution of ideas and projects developed during the current K05 award period. The first aim will utilize the rich data resources of BEACON to develop risk and prediction models which are tailored to the absolute risk of specific populations that will be useful for a) health policy development, b) education, c) clinical decision-making, and d) designing future research. This aims address critical barriers to EA control by facilitating improvement in the costs and effectiveness of EA prevention interventions by ensuring that they make optimum use of knowledge regarding risk factors, protective factors and biomarkers that predict neoplastic progression, response to therapy and survival. The second aim encompasses his continued scientific leadership role in BEACON. Specifically this involves developing and actively participating in ongoing and new pooled analyses with the Consortium members, including ongoing BEACON studies such as analysis of telomere length, IGF-related markers, and adipokines; as well as ancillary analyses to the ongoing genome-wide association study of BE and EA. It also involves developing new collaborative research projects with BEACON investigators and mentees that will take advantage of the diverse populations represented, along with existing banks of well-characterized tissues. Dr. Vaughan has a well-established track record of mentoring graduate students and postdoctoral fellows, as well as junior faculty in Epidemiology and related disciplines. He is Director of an NCI-funded Cancer Epidemiology and Biostatistics Training Grant which funds nine predoctoral and four postdoctoral trainees and runs the journal club. He guest lectures in established epidemiology courses, and has served on 29 master's thesis committees, and 26 doctoral dissertation committees. Mentoring activities funded by the K05 will include: i) those associated with his responsibilities on the training grant, ii) his ongoing mentoring of other trainees from Epidemiology and related departments, and iii) mentoring junior faculty at the UW, FHCRC and outside institutions. Each year, he plans to work closely with two to three predoctoral students, one to two postdoctoral fellows; and one to two junior faculty members.

描述（由申请人提供）：K05 奖项将为 Thomas L Vaughan 博士提供受保护的时间（30% FTE），以继续研究与食管腺癌 (EA) 的病因学和预防相关的关键研究问题，这种癌症在过去四十年中在美国和许多西方国家的发病率显着增加（总体增加 6 倍，白人男性增加 10 倍）。它还将提供受保护的时间（20% FTE），以继续他对华盛顿大学 (UW)、弗雷德·哈钦森癌症研究中心 (FHCRC) 和外部机构的学生、博士后研究员和初级研究人员的广泛指导活动。 他目前获奖的前四年（2007 年 7 月至 2011 年 10 月）为他提供了关键的受保护时间，让他能够专注于进一步发展和加强他的 EA 研究项目。当前奖项的目标 1 资助他对以前从当地研究中收集的数据和生物样本进行分析，但资金已过期。迄今为止，这一集中精力已发表了 20 篇论文，并提交了 8 份手稿，其中许多涉及他对博士前和博士后学员的直接指导。 Vaughan 博士是 2005 年国际巴雷特癌和食管腺癌联盟 (BEACON) 的联合创始人之一，该联盟得到了 NCI 的部分支持。他被选为第一任指导委员会主席并继续担任该职务。当前奖项的目标 2 涉及将 BEACON 建立为 EA 病因学和预防研究的重要纽带。在当前奖项颁发的前四年中，该联盟的成员数量大约增加了一倍，每年举办的研讨会通常有 40-50 名与会者参加。增加了临床胃肠病学、分子生物学、生理学、遗传学、进化生物学和群体遗传学方面的额外专业知识，显着扩大了可用于计划和开展新研究的专家技能和知识的范围。六个研究项目获得了 NCI、NIDDK、英国癌症研究中心和瑞典癌症协会的资助。在过去的两年里，又有六份手稿已出版或提交，还有几份手稿正处于最后的编写阶段。当前奖项的目标 3 涉及在 BEACON 内开发新的合作研究项目。该奖项使 Vaughan 博士能够为一项涉及 14 个地点和约 8,500 名参与者的全基因组关联研究提供多项 PI 资助（于 2009 年末资助）。 K05 奖项的关键在于，它不仅提供了保护时间来开发这一后勤复杂的拨款申请，而且还为 Vaughan 博士提供了遗传流行病学方面的重要培训机会（例如，关于常见疾病遗传学的欢迎信托会议；受邀参加 Illumina 美洲科学峰会以及作为昆士兰医学研究所的访问学者。） 更新期间拟议的研究活动代表了当前 K05 奖励期间开发的想法和项目的直接演变。第一个目标将利用 BEACON 丰富的数据资源来开发风险和预测模型，这些模型适合特定人群的绝对风险，这将有助于 a) 卫生政策制定，b) 教育，c) 临床决策，以及 d) 设计未来的研究。其目的是通过确保充分利用有关预测肿瘤进展、治疗反应和生存的风险因素、保护因素和生物标志物的知识，促进改善 EA 预防干预措施的成本和有效性，从而解决 EA 控制的关键障碍。第二个目标包括他在 BEACON 中继续发挥科学领导作用。具体来说，这涉及与联盟成员一起开发并积极参与正在进行的和新的汇总分析，包括正在进行的 BEACON 研究，例如端粒长度、IGF 相关标记和脂肪因子的分析；以及正在进行的 BE 和 EA 全基因组关联研究的辅助分析。它还涉及与 BEACON 研究人员和学员一起开发新的合作研究项目，这些项目将利用所代表的不同人群以及现有的特征良好的组织库。 沃恩博士在指导研究生和博士后研究员以及流行病学和相关学科的初级教师方面拥有良好的记录。他是 NCI 资助的癌症流行病学和生物统计学培训基金的主任，该基金资助 9 名博士前培训生和 4 名博士后培训生，并运营期刊俱乐部。他客座讲授已建立的流行病学课程，并担任 29 个硕士论文委员会和 26 个博士论文委员会的成员。 K05 资助的指导活动将包括：i）与他在培训补助金方面的职责相关的活动，ii）他对流行病学和相关部门的其他学员的持续指导，以及 iii）指导华盛顿大学、FHCRC 和外部机构的初级教师。每年，他计划与两到三名博士生、一到两名博士后密切合作；以及一到两名初级教员。