TISSUE DIELECTRIC CHANGES DURING HYPERTHERMIA

热疗期间组织介电的变化

• 批准号: 2097375
• 负责人: DONALD A MC RAE
• 金额: $ 13.57万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-05 至 1996-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2097375
• 关键词: dielectric property; electrical impedance; histology; hyperthermia therapy; monitoring device; neoplastic growth; tissues

DESCRIPTION (Adapted from the Investigator's Abstract): The long-term goal of this work is the investigation of tissue electrical impedance changes as a method for detecting and monitoring, in real-time, the tissue changes occurring during therapeutic hyperthermia administered in the clinic. In therapeutic hyperthermia, thermal dose, defined as some function of heating temperature and duration, while being related to, has not invariably proven predictive of a tissue's response to heating. Therefore, to determine whether a treatment goal has been reached during a particular treatment, numerous techniques are being investigated for directly obtaining information on hyperthermia-induced tissue changes.The monitoring of tissue electrical impedance changes is being proposed as an additional method which can provide unique information of tissue response at the cellular level. Extensive data using fresh excised tissue, and preliminary in vivo results, show that tissue impedance changes can be linked with major hyperthermia-induced histological changes occurring at the cell and tissue structure levels. The proposed work takes the next essential step by fully investigating the relationship between in vivo tissue electrical impedance changes and concurrent, hyperthermia-induced histological changes in three experimental tumors. The work is divided into two phases. First, the tumors will be heated in vivo in a water bath, and at selected times, cooled, excised, and measured under controlled conditions in an impedance measurement cell. To relate the tissue electrical impedance changes to the in vivo hyperthermia-induced histological changes existing after different heating times, identically treated tumors will be histologically and morphometrically characterized. Second, utilizing the results from phase I, selected in vivo impedance measurement techniques for providing real-time tissue impedance information simultaneously with the application of hyperthermia to the tumors will be evaluated. The optimum method will then be employed to obtain continuous, in vivo, real-time impedance data on the histological changes occurring in the three tumors during hyperthermia. This leads to subsequent work correlating these impedance changes with tumor growth- delay endpoints.

描述(改编自《调查者摘要》)：长期 这项工作的目的是研究组织的电阻抗 变化作为一种实时检测和监测 治疗性热疗中的组织变化 诊所。在治疗性热疗中，热剂量的定义是 加热温度和持续时间的作用，虽然与 并不总是被证明可以预测组织对加热的反应。 因此，要确定治疗目标是否在 一种特殊的治疗方法，许多技术正在被研究 直接获取关于高温引起的组织变化的信息。 对组织电阻抗变化的监测被提议为 一种可提供组织的唯一信息的附加方法 在细胞水平上的反应。 使用新鲜切除的组织和初步的活体内数据 结果表明，组织阻抗的变化可以与主要 高温引起的组织学改变发生在细胞和 组织结构水平。拟议的工作采取了下一个基本步骤 通过充分研究体内组织电学关系 阻抗变化与并发高温诱导的组织学改变 三种实验性肿瘤的变化。这项工作分为两部分 阶段。首先，肿瘤将在活体水浴中加热， 在选定的时间，在控制下冷却、切除和测量 阻抗测量单元中的条件。为了将组织联系起来 体温升高对体内电阻抗的影响 不同加热时间后的组织学变化相同 治疗后的肿瘤将具有组织学和形态计量学特征。 第二，利用来自阶段I的结果，选择体内阻抗 用于提供实时组织阻抗的测量技术 在应用热疗的同时提供信息 将对肿瘤进行评估。然后将使用最优方法来 获得连续、活体、实时的组织学阻抗数据 三种肿瘤在热疗过程中的变化。这条线索 将这些阻抗变化与肿瘤生长相关联的后续工作- 延迟终结点。