TISSUE DIELECTRIC CHANGES DURING HYPERTHERMIA

热疗期间组织介电的变化

• 批准号: 3200891
• 负责人: DONALD A MC RAE
• 金额: $ 13.51万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-05 至 1996-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3200891
• 关键词: dielectric property; electrical impedance; histology; hyperthermia therapy; monitoring device; neoplastic growth; tissues

DESCRIPTION (Adapted from the Investigator's Abstract): The long-term goal of this work is the investigation of tissue electrical impedance changes as a method for detecting and monitoring, in real-time, the tissue changes occurring during therapeutic hyperthermia administered in the clinic. In therapeutic hyperthermia, thermal dose, defined as some function of heating temperature and duration, while being related to, has not invariably proven predictive of a tissue's response to heating. Therefore, to determine whether a treatment goal has been reached during a particular treatment, numerous techniques are being investigated for directly obtaining information on hyperthermia-induced tissue changes.The monitoring of tissue electrical impedance changes is being proposed as an additional method which can provide unique information of tissue response at the cellular level. Extensive data using fresh excised tissue, and preliminary in vivo results, show that tissue impedance changes can be linked with major hyperthermia-induced histological changes occurring at the cell and tissue structure levels. The proposed work takes the next essential step by fully investigating the relationship between in vivo tissue electrical impedance changes and concurrent, hyperthermia-induced histological changes in three experimental tumors. The work is divided into two phases. First, the tumors will be heated in vivo in a water bath, and at selected times, cooled, excised, and measured under controlled conditions in an impedance measurement cell. To relate the tissue electrical impedance changes to the in vivo hyperthermia-induced histological changes existing after different heating times, identically treated tumors will be histologically and morphometrically characterized. Second, utilizing the results from phase I, selected in vivo impedance measurement techniques for providing real-time tissue impedance information simultaneously with the application of hyperthermia to the tumors will be evaluated. The optimum method will then be employed to obtain continuous, in vivo, real-time impedance data on the histological changes occurring in the three tumors during hyperthermia. This leads to subsequent work correlating these impedance changes with tumor growth- delay endpoints.

描述（改编自研究者摘要）：长期 本工作的目的是研究组织电阻抗 作为一种实时检测和监测的方法， 在进行热疗期间发生的组织变化， 诊所 在热疗中，热剂量，定义为一些 加热温度和持续时间的函数， 并不总是被证明预测组织对加热的反应。 因此，为了确定治疗目标是否已经达到， 一个特殊的治疗，许多技术正在研究， 直接获得关于高血压引起的组织变化的信息。 提出了对组织电阻抗变化的监测， 可以提供组织的独特信息的附加方法 细胞水平的反应。 使用新鲜切除组织的广泛数据，以及初步体内研究 结果表明，组织阻抗变化可以与主要的 高血压诱导的组织学变化发生在细胞和 组织结构水平。 拟议的工作采取了下一个重要步骤 通过充分研究体内组织电 阻抗变化和并发的高血压诱导的组织学 三种实验性肿瘤的变化。 这项工作分为两部分 阶段。 首先，肿瘤将在水浴中体内加热， 在选定的时间，冷却，切除，并在控制下测量， 阻抗测量单元中的条件。 把这些组织 体内高血压诱导的电阻抗变化 不同加热时间后的组织学变化相同， 将对治疗的肿瘤进行组织学和形态学表征。 第二，利用第一阶段的结果，选择体内阻抗 用于提供实时组织阻抗的测量技术 信息的同时，高温的应用， 将对肿瘤进行评估。 然后，将采用最佳方法来 获得组织学的连续、体内、实时阻抗数据 在热疗过程中三种肿瘤发生的变化。 这导致 随后的工作将这些阻抗变化与肿瘤生长联系起来- 延迟端点。