Molecular Analysis of Surface Functionalization of Nanomaterials

纳米材料表面功能化的分子分析

• 批准号: 104968
• 金额: $ 3.16万
• 依托单位: HEXAGONFAB LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=104968
• 关键词: Molecular; Analysis; Surface; Functionalization; Nanomaterials

Each year more than 800'000 people in the UK see their GP for suspected influenza infection and 20-30'000 hospital people are admitted to hospitals. Hospitals face the daily risk that incoming patients (100,000 in the Emergency Room 2017 in Addenbrooke's Hospital in Cambridge) will lead to Influenza outbreaks in the hospital. Indeed, there were more 700 confirmed influenza cases last year at Addenbrooke's hospital, and three ward closures due to Influenza outbreaks.To prevent outbreaks, patients must be tested for influenza before antiviral treatment is initiated. Unfortunately, this testing process can take several hours, resulting in delayed diagnosis and treatment. The current established and trusted "gold standard" method of testing for influenza in hospitals can take up to 12 hours. A delay of half a day is highly costly to the patient and hospital: patients must wait longer to be seen by the correct department, wards become congested with patients waiting for test results and the risk of viral outbreaks increases as potential carriers of the virus wait for results. Clinicians have expressed a need for rapid detection influenza tests that can be carried out by non-medically trained personal in the Emergency Room. A selection of currently existing rapid diagnostic tests (RDTs) has been tried. The sensitivity of most have been shown to be insufficient, thus often resulting in false negatives.There is an urgent need for a novel rapid diagnostic test for influenza virus that can be used in hospital emergency rooms. At HexagonFab, a biosensor has been developed and built from novel nanomaterials, which will bring the sensitivity of laboratory based tests to the emergency room. The technology gains its outstanding sensitivity through the unique surface of the nanomaterial, which is the core sensing element. In order to optimise the sensor, it is necessary to gain a deep understanding of how the nanomaterial interacts with its environment and how it can be tailored to be even more sensitive and specific. The InnovateUK A4I project brings the unique expertise of leading research organisations in the UK to investigate the surface of the nanomaterial and how the sensor can be optimised to achieve the sensitivity of current laboratory-based tests, while allowing use at the patient in the emergency room.

在英国，每年有超过80万人因疑似流感感染而去看他们的全科医生，20-30万人住院。医院每天都面临着新来的病人（2017年剑桥Addenbrooke医院急诊室有10万人）导致医院流感爆发的风险。事实上，去年阿登布鲁克医院有700多例确诊流感病例，三个病房因流感爆发而关闭。为防止疫情爆发，患者必须在开始抗病毒治疗前进行流感检测。不幸的是，这个测试过程可能需要几个小时，导致延误诊断和治疗。目前在医院建立和信任的流感检测“金标准”方法可能需要长达12小时。半天的延迟对患者和医院来说都是非常昂贵的：患者必须等待更长的时间才能被正确的部门看到，病房因等待检测结果的患者而变得拥挤，并且由于潜在的病毒携带者等待结果，病毒爆发的风险增加。临床医生表示需要快速检测流感测试，可以由未经医学培训的人员在急诊室进行。已经尝试了一些现有的快速诊断测试（RDTs）。大多数的灵敏度已经被证明是不够的，因此经常导致假阴性。有一个迫切需要一个新的快速诊断测试流感病毒，可用于医院急诊室。在HellonFab，一种生物传感器已经开发出来，并由新型纳米材料制成，这将使实验室测试的灵敏度提高到急诊室。该技术通过纳米材料的独特表面获得了出色的灵敏度，这是核心传感元件。为了优化传感器，有必要深入了解纳米材料如何与其环境相互作用，以及如何对其进行定制，使其更加敏感和特异。InnovateUK A4 I项目汇集了英国领先研究机构的独特专业知识，以研究纳米材料的表面，以及如何优化传感器以实现当前实验室测试的灵敏度，同时允许在急诊室的患者身上使用。