Methodology Core

项目总结（见说明）： 方法学核心的总体目标是提供生物统计学、结果和临床研究方面的创新方法学专业知识，以及成功完成拟议的MCRC项目和研究基地内其他重要项目所需的沿着计算资源。该核心还提供了一个教育资源，旨在提高达特茅斯肌肉骨骼疾病研究计划的方法质量。具体目标是：1）促进所有MCRC项目的实施和完成，并通过提供生物统计学，研究设计，成果和其他方面的专业知识， 研究、数据管理和先进计算，2）提供对专业数据库和计算资源的访问，3）建立一个有针对性的教育论坛，通过在多学科临床研究中举办研究进展研讨会，以肌肉骨骼疾病为重点，为研究基地内代表的学术课程的博士前和博士后学员举办专门研讨会和指导研究课程，并为研究生和研究生课程的高级学员提供方法指导 隶属于MCRC，4）为MCRC项目的研究审查和数据及安全监测提供方法学支持，5）促进对研究基地内特定领域发展至关重要的问题的方法学研究。该核心是高度集成，并与整个达特茅斯的定量和教育资源紧密结合，允许更广泛的代表性和整个机构的专业知识的相互分享。

PROJECT SUMMARY (See instructions): The overall objective of the Methodology Core is to provide access to innovative methodological expertise in biostatistics, outcomes and clinical research and along with computational resources necessary for the successful completion of the proposed MCRC projects and other important projects within the research base. The Core also provides an educational resource with the intent of enhancing the methodological quality of research initiatives in musculoskeletal diseases at Dartmouth. The specific aims are 1) to facilitate the implementation and completion of all MCRC projects and to assist investigators within the research base by providing expertise in biostatistics, research design, outcomes research, data management, and advanced computing, 2) to provide access to specialized data bases and computing resources, 3) to establish a targeted educational forum to foster methodological expertise within the existing research base by conducting research-in progress seminars in multidisciplinary clinical research with a focus on musculoskeletal disease, specialized seminars and directed research courses for pre- and post-doctoral trainees in the academic programs represented within the research base, and methodological mentorship for advanced trainees in graduate and post-graduate programs affiliated with the MCRC, 4) to provide methodological support for research review and data and safety monitoring for MCRC projects, and 5) to promote methodologic research in issues critical to the advancement of specific areas within the research base. The Core is highly integrated and closely aligned with quantitative and educational resources throughout Dartmouth, allowing for a broader representation and mutual sharing of expertise across the institution.