RESEARCH IN CANCER EPIDEMIOLOGY AND BIOSTATISTICS

要求提供资金，以扩大旧金山部分的 黑人、白人前列腺癌的人群病例对照研究 亚裔美国人的指挥范围从10-1-89到8-31-94。延伸区 将收集所有报告前列腺癌的受试者的癌症系谱数据 一个或多个一级亲属的癌症，以及随机抽样的 那些没有这样做的人。目标是：i)将病例和对照与 尊重以前报告的个人特征(饮食、身体状况 活动，体型)，同时按亲属的数量和类型分层 与前列腺癌；ii)比较观察到的特定部位的癌症 病例家庭发病率与区域发病率预期的比较 比率；iii)确定家族性前列腺癌模式是否表明 主要易感基因，如果是这样的话，估计一个或 这种基因的更多有害等位基因以及特定的年龄和种族 前列腺癌携带者的风险；iv)确定有三个携带者的家庭 或以上确诊前列腺癌病例(包括先证者) 一级或二级亲属和这些家庭中，找到 与前列腺癌共分离的遗传标记，从而识别 一个或多个易感基因的候选基因。优势所在 项目包括：1)详细的家族史，从同一 黑人、白人和亚洲男性之前提供了关于饮食、身体状况的数据 活动和体型，允许评估以下因素的综合影响 前列腺癌的遗传易感性和生活方式特征 风险；2)隔离分析，如果支持重大诱因 基因，将提供基于群体的基因频率估计和 外显及其随年龄和种族的变化；3)约30-40个家庭 有三个或更多前列腺癌病例允许进行连锁分析 找出易感基因，为深入了解 所有前列腺癌的发生；4)从 同样的高危个体将允许未来类固醇的比较 突变携带者与非携带者体内激素及其代谢产物 等位基因。

Funds are requested to extend the San francisco component of a population-based case-control study of prostate cancer among black, white and Asian Americans conducted from 10-1-89 to 8-31-94. The extension will gather cancer pedigree data from all subjects who reported prostate cancer in one or more first-degree relatives, and a random sample of those who did not. Objectives are: i) to compare cases and controls with respect to previously reported personal characteristics (diet, physical activity, body size), while stratifying by number and type of relatives with-prostate cancer; ii) to compare observed site-specific cancer incidence in families of cases to that expected from regional incidence rates; iii) to determine if familial prostate cancer patterns suggest a major predisposing gene and if so, to estimate the frequency of one or more deleterious alleles of such a gene and the age- and race-specific prostate cancer risks among carriers; iv) to identify families with three or more confirmed prostate cancer cases (including the proband) among first- or second-degree relatives and within these families, to find genetic markers that co-segregate with prostate cancer and thus identify candidate loci for a predisposing gene or genes. Strengths of the project include: 1) detailed family histories, obtained from the same black, white and Asian men who previously provided data on diet, physical activity and body size, permit assessment of the combined effects of genetic susceptibility and lifestyle characteristics on prostate cancer risk; 2) segregation analysis, if supportive of a major predisposing gene, will provide population-based estimates of gene frequency and penetrance and their variation with age and race; 3) some 30-40 families with three or more cases of prostate cancer permit linkage analysis to identify predisposing genes that could provide insight into the development of all prostate cancers; 4) banked serum and DNA from the same high-risk individuals will allow future comparison of steroid hormones and their metabolites in carriers and non-carriers of mutated alleles.