PROSTATE SCREENING ADHERENCE IN AFRICAN AMERICAN MEN

老年非裔美国男性坚持前列腺癌筛查， 据报道，该疾病的高危人群 很低。然而，对与坚持以下行为相关的因素知之甚少 筛查或关于可用于增加 在这一高危人群中进行筛查。拟议的研究应产生一个 提高对非洲裔美国男性筛查障碍的认识 并应告知未来方法的发展和应用 在这个和其他地方提高前列腺癌筛查的依从性 高危人群。 这项拟议的为期三年的研究将由狐狸大通癌症中心进行 中心与芝加哥大学泌尿外科肿瘤学小组 (UOG)和芝加哥大学卫生服务(UHS)。年龄较大(50至70岁) 非洲裔美国男性将连续两轮被提供 免费筛查(直肠指检(DRE)和前列腺特异性 每隔一年进行一次抗原(PSA)检测(即连续筛查)。 最初，将在UHS患者群体中确定715名受试者。 将对研究对象进行电话调查。总体而言，我们 估计样本中的500名(70%)受试者将完成调查。 完成调查的受试者将被随机分配到 对照组(N=250)或治疗组(N=250)。这些人中的毫升 将在两个月后邮寄一封放映邀请函 接受了调查。对照组受试者接受常规护理。一封信就能 邮寄给他们，邀请他们为自由前列腺预约 UOG办公室提供放映服务。联系UOG的对象将是 给出筛查的时间、日期和地点。筛选 结果将被发送给患者和他的医生。治疗组 受试者将接受正常护理和一系列行为干预 (即，教育小册子(ProRecord)、教学电话 (ITC)和邮寄提醒函(RL)。遵守将被定义为 在接受DRE和PSA测试的90天内 放映邀请函已经寄出。筛选结果将发送至 每个受试者和他的医生。 描述性分析将有助于从以下方面描述研究对象的特征 社会人口背景、病史、风险因素和知识， 关于前列腺癌和筛查的态度和信念(Kabs)。 这些因素和依从性之间的双变量关联将是 评估过了。最后，显著相关的因素(α=0.05) 将在多变量分析中使用，以确定 遵守的独立预测因素。作为这些分析的一部分， 行为干预对受试者的独立影响 被评估。

Adherence to prostate cancer screening among older African American men, a population group at high risk for the disease, has been reported to be low. However, little is known about factors associated with adherence to screening or about effective approaches which may be used to increase screening in this high-risk group. The proposed study should result in an improved understanding of barriers to Screening among African American men and should also inform the future development and application of methods for increasing adherence to prostate cancer screening in this and other high-risk populations. The proposed three-year study will be conducted by the Fox Chase Cancer Center together with the University of Chicago Urologic-Oncology Group (UOG) and the University of Chicago Health Service (UHS). Older (50 to 70 years of age) African American men will be offered two consecutive rounds of free screening (digital rectal examination (DRE) and prostate specific antigen (PSA) testing) at a one-year interval (i.e., serial screening). Initially, 715 subjects will be identified in the UHS patient population. A telephone survey will be administered to study subjects. Overall, we estimate that 500 (70%) subjects in the sample will complete the survey. Subjects who complete the survey will be randomly assigned either to a CONTROL GROUP (N=250) or TREATMENT GROUP (N=250). Ml of these individuals will be mailed a Screening invitation letter two months after being surveyed. CONTROL GROUP subjects will receive Normal Care. A letter will be mailed which invites them to schedule an appointment for free prostate screening offered at the UOG office. Subjects who contact the UOG will be given a time, date, and location for the screening examination. Screening results will be sent to the patient and his physician. TREATMENT GROUP subjects will receive Normal Care plus a set of behavioral interventions (i.e., an educational booklet (ProRecord), an instruction telephone call (ITC), and a mailed reminder letter (RL). Adherence will be defined as undergoing DRE and PSA testing within 90 days of the date on which the screening invitation letter was mailed. Screening results will be sent to each subject and his physician. Descriptive analyses will serve to characterize study subjects in terms of sociodemographic background, medical history, risk factors, and knowledge, attitudes and beliefs (KABs) about prostate cancer and screening. Bivariate associations between these factors and adherence will be assessed. Finally, factors that are significantly associated (alpha=0.05) with adherence in will be used in multivariate analyses to identify independent predictors of adherence. As part of these analyses, the independent effect of subject exposure to the behavioral intervention will be evaluated.