The Regulatory Network of Histone Methylating and Demethylating Enzymes

组蛋白甲基化和去甲基化酶的调控网络

• 批准号: DP200100129
• 负责人: Prof Marc Wilkins
• 金额: $ 33.09万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100129
• 关键词: Regulatory; Network; Histone; Methylating; Demethylating

This project aims to discover how cells regulate histone methylation enzymes. This process ultimately affects which genes can be turned on or off inside cells; something which is central to growth and development in all animals, all plants and some microbes. Expected outcomes include new knowledge on the regulation of histone methylation, improved techniques for the study of this process and enhanced capacity for international collaboration. New avenues for the artificial regulation of genes may also emerge for synthetic epigenetics. The project should provide significant new findings for the research community, generate research citations and contribute to a highly skilled workforce by the training of staff and students.

该项目旨在发现细胞如何调节组蛋白甲基化酶。这一过程最终会影响细胞内哪些基因可以被打开或关闭;这是所有动物、植物和一些微生物生长和发育的核心。预期成果包括关于组蛋白甲基化调控的新知识，改进研究这一过程的技术，以及加强国际合作的能力。人工调控基因的新途径也可能出现合成表观遗传学。该项目将为研究界提供重要的新发现，产生研究引文，并通过培训工作人员和学生为高技能劳动力做出贡献。