Protein methylation: a fundamental regulator of the interactome

蛋白质甲基化：相互作用组的基本调节因子

• 批准号: DP1093388
• 负责人: Prof Marc Wilkins
• 金额: $ 19.85万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093388
• 关键词: Protein; methylation; fundamental; regulator; interactome

Proteins are the functional molecules of the cell. They interact with each other to form small 'protein machines' that are part of large, complicated networks. This study will examine how the cell makes tiny changes to proteins, through the addition of one carbon and two hydrogen atoms, and how this is important in the regulation of protein interactions. The proteins of baker's yeast, a common model organism, will be studied here. However, the findings will be directly relevant to understanding the function of many proteins in plants, animals and man.

蛋白质是细胞的功能分子。它们相互作用，形成小型的“蛋白质机器”，这些机器是大型复杂网络的一部分。这项研究将研究细胞如何通过添加一个碳原子和两个氢原子来对蛋白质进行微小的改变，以及这在调节蛋白质相互作用中的重要性。面包酵母，一种常见的模式生物，蛋白质将在这里进行研究。然而，这些发现将直接关系到理解植物，动物和人类中许多蛋白质的功能。