The effect of methylation and phosphorylation on ribosome function

甲基化和磷酸化对核糖体功能的影响

• 批准号: DP220102338
• 负责人: Prof Marc Wilkins
• 金额: $ 44.33万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102338
• 关键词: effect; methylation; phosphorylation; ribosome; function

This project aims to discover how cells regulate ribosome function and selectivity, by modifying their ribosomal proteins. This affects protein synthesis, a process which is central to the growth of all living things. Expected outcomes include new knowledge on the regulation of protein synthesis, improved techniques for the study of this process and an enhanced capacity for international collaboration. New avenues for the artificial regulation of the ribosome may also emerge, relevant to synthetic biology and the engineering of industrial yeasts. The project should provide significant new findings for the research community, generate research citations and contribute to a highly skilled workforce by the training of staff and students.

该项目旨在发现细胞如何通过修改其核糖体蛋白来调节核糖体的功能和选择性。这会影响蛋白质合成，而蛋白质合成是所有生物生长的核心过程。预期成果包括关于蛋白质合成调控的新知识，改进这一过程的研究技术以及加强国际合作的能力。人工调控核糖体的新途径也可能出现，与合成生物学和工业酵母工程有关。该项目应为研究界提供重要的新发现，产生研究引用，并通过培训员工和学生为高技能劳动力做出贡献。