Decision-making modules in protein interaction networks

蛋白质相互作用网络中的决策模块

• 批准号: DP170100108
• 负责人: Prof Marc Wilkins
• 金额: $ 25.24万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100108
• 关键词: Decision; making; modules; protein; interaction

This project aims to discover how cells use proteins to make decisions. This is important for all living things, which must react to stimuli to grow, adapt, defend themselves and to die. The project’s anticipated outcome is the systems-level identification of decision-making modules in an intracellular network. Its focus is on the smallest possible modules, which contain a decision-making protein with two modifications that control protein-proteins interactions. It will investigate two recurrent decision-making modules. The expected benefits of the project include new means to decipher biological complexity, and targets to modulate biosystems by genome editing or with drugs.

该项目旨在发现细胞如何使用蛋白质做出决定。这对所有生物都很重要，它们必须对刺激做出反应，以生长，适应，保护自己和死亡。该项目的预期成果是在细胞内网络的决策模块的系统级识别。它的重点是最小的可能模块，其中包含一个决策蛋白质，具有两个控制蛋白质相互作用的修饰。它将研究两个经常性的决策模块。该项目的预期好处包括破译生物复杂性的新方法，以及通过基因组编辑或药物调节生物系统的目标。