Real-time neuronal network imaging using diamond optrode arrays

使用金刚石光极阵列的实时神经网络成像

• 批准号: DP200103712
• 负责人: A/Prof David Simpson
• 金额: $ 30.96万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103712
• 关键词: Real; time; neuronal; network; imaging

The project aims to develop new imaging technology for real time recording of electrical activity from cell and neuronal networks with unprecedented resolution and scale. The technology innovation stems from an optical defect in diamond which can be engineered to sensitively detect local changes in electric field. The all-optical diamond optrode array devices will be applied to biological model systems including cardiomyocytes, mammalian cells, and neurons; and will be benchmarked against current state-of-the-art technologies. The knowledge gained from the high density recordings will aid predictive models of disease and will lead to an improved understanding of the brain’s micro circuity and functional connectome.

该项目旨在开发新的成像技术，以实时记录具有前所未有的分辨率和规模的细胞和神经元网络的电活动。技术创新停止了钻石中的光学缺陷，该缺陷可以设计为敏感地检测到电场的当地变化。全光钻石Optrode阵列设备将应用于包括心肌细胞，哺乳动物细胞和神经元在内的生物模型系统。并将针对当前的最新技术进行基准测试。从高密度记录中获得的知识将有助于疾病的预测模型，并会提高人们对大脑微循环率和功能连接组的了解。