TOOTH-SALIVA INTERFACE PHENOMENA AND DENTAL CARIES

牙齿-唾液界面现象和龋齿

• 批准号: 2128929
• 负责人: DONALD I HAY
• 金额: $ 27.2万
• 依托单位: ADA FORSYTH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2128929
• 关键词: calcium metabolism; dental caries; dental plaque; glycoproteins; goats; histidine; laboratory rabbit; pellicle; periodontium disorder; phosphates; physical chemical interaction; proline; saliva; tooth; tooth enamel; tooth surface; tyrosine

Our recent research has established that a system exists in human saliva which plays an important role in the maintenance, protection and repair of dental enamel. The key features of this system are the presence in saliva of, firstly, supersaturated but stabilized concentrations of calcium and phosphate ions, and secondly, two kinds of salivary macromolecules which stabilize the supersaturated saliva by inhibiting precipitation of calcium phosphate salts. The supersaturated saliva provides important protection for the teeth by providing driving forces which, firstly, stabilize the enamel mineral, secondly, oppose enamel dissolution and mineral transport during carious attack of the teeth, and, thirdly, provides a mechanism for the repair of many early carious lesions. The precipitation inhibitors control this supersaturation by, firstly, preventing precipitation of calcium phosphate salts in the salivary glands and the oral cavity, and secondly, because they inhibit crystal growth of calcium phosphate salts, they prevent unwanted accretion of mineral onto the tooth surface. Significantly, their mechanisms of action do not affect calcium and phosphate ion activities in the saliva. Also, it is probable that one or both of the inhibitors contribute to the formation of the acquired enamel pellicle, a protein integument present on the enamel surface which provides significant protection for the teeth. The purpose of the proposed research is to elucidate the mechanisms by which the precipitation inhibitors act, both in terms of their molecular structures, which are now partly known, and in terms of their post-secretion behavior in the oral cavity. In addition, we propose to establish their broad biological significance by studying species other than human, particularly sub-human primates and laboratory animals used for dental caries and periodontal disease research. From this research will come an improved understanding of important relationships which exist between the teeth and their oral environment, both in health and disease.

我们最近的研究证实，人类唾液中存在一个系统， 对牙齿的维护、保护和修复起着重要作用 搪瓷。 该系统的主要特征是唾液中存在以下物质： 钙离子和磷酸根离子的过饱和但浓度稳定，以及 其次，两种唾液大分子可以稳定唾液 通过抑制磷酸钙盐的沉淀来使唾液过饱和。 过饱和的唾液通过以下方式为牙齿提供重要的保护： 提供驱动力，首先稳定牙釉质矿物，其次， 在龋齿侵袭期间阻止牙釉质溶解和矿物质运输 牙齿，第三，提供了修复许多早期龋齿的机制。 病变。 沉淀抑制剂首先通过以下方式控制这种过饱和： 防止磷酸钙盐在唾液腺中沉淀， 其次，因为它们抑制钙晶体的生长 磷酸盐，它们可以防止矿物质在牙齿上不必要的沉积 表面。 值得注意的是，它们的作用机制不影响钙和 唾液中磷酸根离子的活性。 此外，很可能其中之一或两者 抑制剂有助于获得性牙釉质薄膜的形成， 牙釉质表面存在蛋白质外被，提供了重要的 对牙齿的保护。 拟议研究的目的是阐明该机制 沉淀抑制剂的作用在于其分子结构， 现在已部分了解，并且就其在口腔中的分泌后行为而言 空腔。 此外，我们建议建立广泛的生物 通过研究人类以外的物种，特别是亚人类，具有重要意义 用于治疗龋齿和牙周病的灵长类动物和实验动物 研究。 通过这项研究，我们将更好地理解重要的 牙齿与其口腔环境之间存在的关系 健康和疾病。