LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
批准号:
2124319
负责人:
Robert M Bradley
金额:
$17.54万
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-04-01 至 1997-03-31
关键词:
afferent nerve axon cell biology chemoreceptors clinical biomedical equipment developmental neurobiology electrodes electrophysiology laboratory rat nervous system regeneration neural information processing neural plasticity peripheral nervous system single cell analysis statistical service /center synapses taste taste buds
中文摘要
这项研究的主要目的是开发一种可植入的
记录电极将允许对未切割的,
在未麻醉的动物中长时间的单一味觉纤维。 一个
可植入电极,由具有筛状结构的硅芯片组成
小孔和相关电极的阵列,将被放置在小
管. 然后将电极和管通过外科手术植入
大鼠颈部,切断舌咽神经,位于
管子。 再生的纤维通过硅片上的孔生长,
与电极贴壁。 随后,录音将从
慢性制剂中的单一味觉纤维。 因此,技术将
可用于接近一个基本问题的细胞生物学的
味觉系统:在多大程度上是一个单一的传入纤维的反应,
在味蕾细胞更新和突触形成的持续过程中保持稳定
改造? 此外,我们建议使用这种植入式器械,
检查和分析纤维对化学物质的反应模式
舌头的刺激。 这些研究将提供基本信息,
关于单一传入反应的稳定性
味觉细胞更新和突触变化。 这些信息将提供
关于味觉系统细胞生物学的重要新数据,
应用于味觉的神经编码问题。 此外,发展
可植入电极的技术应用
来恢复周围神经的再生功能。
英文摘要
The primary objective of this research is to develop an implantable
recording electrode that will permit electrophysiological study of uncut,
single taste fibers for long time periods in unanesthetized animals. An
implantable electrode, that consists of a silicon chip with a sieve-like
array of small holes and associated electrodes, will be placed in small
tubes. The electrode and tube will then be surgically implanted in the
neck of rats, with the cut glossopharyngeal nerve positioned in each end of
the tube. Regenerated fibers grow through the holes in the silicon chip in
apposition to electrodes. Subsequently, recordings will be made from
single taste fibers in chronic preparations. Thus, techniques will be
available to approach a fundamental question about the cell biology of the
taste system: to what extent is the response from a single afferent fiber
stable during the ongoing processes of taste bud cell turnover and synaptic
remodeling? In addition we propose to use this implantable device to
examine and analyze the response patterns across fibers to chemical
stimulation of the tongue. These studies will contribute basic information
about the stability of the single afferent response during processes of
taste cell turnover and synaptic changes. This information will provide
important new data about the cell biology of the taste system that can be
applied to questions of neural coding in taste. In addition, development
of the implantable electrode can have important applications in technology
to restore function in regenerating peripheral nerves.
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会议论文
Development of the Gustatory Solitary Nucleus
-
批准号:8020949
-
项目类别:
-
资助金额:$31.2万
-
财政年份:2009
-
负责人:Robert M Bradley
-
依托单位:
Development of the Gustatory Solitary Nucleus
-
批准号:7631609
-
项目类别:
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资助金额:$32.55万
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财政年份:2009
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负责人:Robert M Bradley
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依托单位:
Development of the Gustatory Solitary Nucleus
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批准号:7763892
-
项目类别:
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资助金额:$32.23万
-
财政年份:2009
-
负责人:Robert M Bradley
-
依托单位:
Development of the Gustatory Solitary Nucleus
-
批准号:8230743
-
项目类别:
-
资助金额:$31.2万
-
财政年份:2009
-
负责人:Robert M Bradley
-
依托单位:
Development of the Gustatory Solitary Nucleus
-
批准号:8423351
-
项目类别:
-
资助金额:$29.64万
-
财政年份:2009
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:6379509
-
项目类别:
-
资助金额:$23.79万
-
财政年份:1999
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:2899098
-
项目类别:
-
资助金额:$24.42万
-
财政年份:1999
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:6649331
-
项目类别:
-
资助金额:$25.58万
-
财政年份:1999
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:6523487
-
项目类别:
-
资助金额:$24.67万
-
财政年份:1999
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:6176783
-
项目类别:
-
资助金额:$23.0万
-
财政年份:1999
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:2124320
-
项目类别:
-
资助金额:$17.54万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:2124318
-
项目类别:
-
资助金额:$16.54万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:3215507
-
项目类别:
-
资助金额:$16.27万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:3215504
-
项目类别:
-
资助金额:$15.89万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:2468762
-
项目类别:
-
资助金额:$7.5万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:3215506
-
项目类别:
-
资助金额:$16.17万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
LONG TERM RECORDING FROM AFFERENT TASTE FIBERS
-
批准号:3215505
-
项目类别:
-
资助金额:$15.75万
-
财政年份:1990
-
负责人:Robert M Bradley
-
依托单位:
SENSORY DISORDERS AND LANGUAGE STUDY SECTION
-
批准号:3555347
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1988
-
负责人:Robert M Bradley
-
依托单位:
SENSORY DISORDERS AND LANGUAGE STUDY SECTION
-
批准号:3555339
-
项目类别:
-
资助金额:$2.92万
-
财政年份:1988
-
负责人:Robert M Bradley
-
依托单位:
MICROSCOPE AND MOCROTOME
-
批准号:3526046
-
项目类别:
-
资助金额:$2.3万
-
财政年份:1987
-
负责人:Robert M Bradley
-
依托单位:
海外基金