NEURAL CONTROL OF RENAL FUNCTION

这项流行研究的总体目标是检验这一假设 肾神经代表一种重要的传入和传出 正常人多项肾功能调节的控制系统 以及病态的情况。我们之前的工作发现增加了 传出肾交感神经活动是一种重要的终极共同特征 水肿形成时肾钠滞留增加的途径 各州。具体目标是：(1)衡量相对贡献率 心肺压力感受器与窦主动脉压力感受器的关系 传出性肾交感神经活动与肾钠滞留 实验性心肌性充血性心力衰竭大鼠模型 梗塞，(2)测量心肺功能的相对贡献 与肝内压力感受器相比，窦主动脉压力感受器的增加 传出性肾交感神经活动与肾钠滞留 大鼠胆总管致实验性胆汁性肝硬变 结扎，(3)测量心肺功能的相对贡献 和窦主动脉压力感受器与肾感觉感受器之间的关系 传出肾交感神经活动和肾钠的增加 阿霉素致大鼠实验性肾病综合征的滞留 行政管理。不同的肾性钠盐实验模型 滞留和水肿的形成很好地表征和建立在 实验室。对于特定目标1-3，血流动力学测量和 电生理技术(单纤维传入和传出 神经纤维记录)将被用来测量 各种可能的反射站对传出肾的增加 交感神经活动和肾脏钠离子滞留的观察 模特们。这些研究将有助于更清楚地定义 传出肾反射控制的病理生理改变 这些临床相关肾脏模型的交感神经活动 钠滞留和浮肿的形成。

The overall objective of the poposed research is to test the hypothesis that the renal nerves represent an important afferent and efferent control system for the regulation of several renal functions in normal and pathological conditions. Our previous work has identified increased efferent renal sympathetic nerve activity as an important final common pathway mediating the increased renal-sodium retention of edema forming states. The specific aims are: (1) to measure the relative contribution of cardiopulmonary versus sinoaortic baroreceptors to the increase in efferent renal sympathetic nerve activity and renal sodium retention in rats with experimental congestive heart failure due to myocardial infarction, (2) to measure the relative contribution of cardiopulmonary and sinoaortic versus intrahepatic baroreceptors to the increase in efferent renal sympathetic nerve activity and renal sodium retention in rats with experimental biliary cirrhosis due to common bile duct ligation, (3) to measure the relative contribution of cardiopulmonary and sinoaortic baroreceptors versus renal sensory receptors to the increase in efferent renal sympathetic nerve activity and renal sodium retention in rats with experimental nephrotic syndrome due to adriamycin administration. The various experimental models of renal sodium retention and edema formation are well characterized and established in the laboratory. For specific aims 1-3, hemodynamic measurements and electrophysiological techniques (single fiber afferent and efferent nerve fiber recording) will be used to measure the contribution of various putative reflex stations to the increase in efferent renal sympathetic nerve activity and renal sodium retention observed in the models. These studies will serve to more clearly define the pathophysiological alterations in reflex control of efferent renal sympathetic nerve activity in these clinically relevant models of renal sodium retention and edema formation.