TRANSGENIC AND TARGETED MUTANT PRESERVATION

通过基因转移选择性地改变小鼠基因组的能力 (转基因小鼠)、同源重组(基因打靶)和化学 诱变技术为生物医学研究提供了新的强有力的工具。 转基因小鼠的生产和使用自其诞生以来迅速扩大 成立于1980年，虽然是一项相对较新的技术，基因 目标定位有望同样迅速地发展。最近，科学家们已经 对《公约》的保存、健康和免费分发表示关切 这些动物。这些小鼠代表了一种极其有价值的生物医学 资源，必须保护它们，防止意外丢失。研究人员 正在收到大量关于他们生产的小鼠的请求和免费的 在不同健康状态的群体之间交换小鼠可能会造成 对全世界所有研究群体的健康构成威胁。此外, 许多生产这些小鼠的研究人员希望从 对它们的分发负责。杰克逊实验室已经 维护、保存和分发近交系和突变株系 60多年了。该实验室已经创造了一些遗传资源 识别、维护和分配重要的突变小鼠。最近一段时间 实验室建立了诱变资源(IMR)，其目的是 进口、冷冻保存和分发具有重要生物医学意义的转基因产品， 靶向和化学诱导的突变小鼠。这样做的目的是 申请是为进口和超低温保存申请资金 转基因和靶向突变小鼠。然后这些老鼠就会自由地 在收回成本的基础上分发给科学界。通过 作为转基因和靶向小鼠的国家资源， 杰克逊实验室将提供健康、保存和 这些重要的生物医学动物的分布。

The ability to selectively alter the mouse genome through gene transfer (transgenic mice), homologous recombination (gene targeting) and chemical mutagenesis is providing new and powerful tools for biomedical research. The production and use of transgenic mice has rapidly expanded since its inception in 1980 and, although a relatively new technology, gene targeting promises to develop as swiftly. Recently, scientists have expressed concerns about the preservation, health and free distribution of these animals. These mice represent an extremely valuable biomedical resource and they must be protected against accidental loss. Researchers are receiving numerous requests for mice they have produced and the free exchange of mice between colonies of varying health status may pose a threat to the health of all research colonies, worldwide. In addition, many researchers who produce these mice want to be relieved of the responsibility for their distribution. The Jackson Laboratory has maintained, preserved and distributed inbred strains and mutant stocks for over 60 years. The Laboratory has created a number of genetic resources that identify, maintain and distribute important mutant mice. Recently the Laboratory established the Induced Mutant Resource (IMR) whose purpose is to import, cryopreserve and distribute biomedically important transgenic, targeted and chemically induced mutant mice. The purpose of this application is to seek funds for the importation and cryopreservation of transgenic and targeted mutant mice. These mice will then be freely distributed to the scientific community on a cost recovery basis. By serving as a National Resource for Transgenic and Targeted mice, the Jackson laboratory will provide for the health, preservation and distribution of these important biomedical animals.