TRANSGENIC AND TARGETED MUTANT PRESERVATION

通过基因转移选择性改变小鼠基因组的能力 （转基因小鼠），同源重组（基因靶向）和化学 诱变为生物医学研究提供了新的和强有力的工具。 转基因小鼠的生产和使用自其问世以来迅速扩大， 1980年成立，虽然是一项相对较新的技术， 目标定位也有望迅速发展。最近，科学家们 表示关切的是， 这些动物。 这些老鼠代表了一种极其有价值的生物医学 资源，必须防止意外损失。 研究人员 收到了许多要求他们生产的老鼠和免费的老鼠的请求。 在不同健康状况的群体之间交换老鼠可能会造成 威胁到全世界所有研究殖民地的健康。 此外，本发明还提供了一种方法， 许多生产这些老鼠的研究人员希望摆脱 负责分配。 杰克逊实验室 维持、保存和分发近交系和突变株， 超过60年。该实验室已经创造了一些遗传资源， 识别、维持和分配重要的突变小鼠。最近 实验室建立了诱导突变资源（IMR），其目的是 进口、冷冻保存和分发具有重要生物医学意义的转基因生物， 靶向和化学诱导的突变小鼠。 这样做的目的 申请是为了寻求进口和冷冻保存的资金 转基因和靶向突变小鼠。然后这些老鼠就可以自由地 在成本回收的基础上分发给科学界。通过 作为转基因和靶向小鼠的国家资源， 杰克逊实验室将提供健康，保存和 这些重要的生物医学动物的分布。

The ability to selectively alter the mouse genome through gene transfer (transgenic mice), homologous recombination (gene targeting) and chemical mutagenesis is providing new and powerful tools for biomedical research. The production and use of transgenic mice has rapidly expanded since its inception in 1980 and, although a relatively new technology, gene targeting promises to develop as swiftly. Recently, scientists have expressed concerns about the preservation, health and free distribution of these animals. These mice represent an extremely valuable biomedical resource and they must be protected against accidental loss. Researchers are receiving numerous requests for mice they have produced and the free exchange of mice between colonies of varying health status may pose a threat to the health of all research colonies, worldwide. In addition, many researchers who produce these mice want to be relieved of the responsibility for their distribution. The Jackson Laboratory has maintained, preserved and distributed inbred strains and mutant stocks for over 60 years. The Laboratory has created a number of genetic resources that identify, maintain and distribute important mutant mice. Recently the Laboratory established the Induced Mutant Resource (IMR) whose purpose is to import, cryopreserve and distribute biomedically important transgenic, targeted and chemically induced mutant mice. The purpose of this application is to seek funds for the importation and cryopreservation of transgenic and targeted mutant mice. These mice will then be freely distributed to the scientific community on a cost recovery basis. By serving as a National Resource for Transgenic and Targeted mice, the Jackson laboratory will provide for the health, preservation and distribution of these important biomedical animals.