MOUSE MUTANT RESOURCE: AIDS

小鼠突变资源：艾滋病

• 批准号: 7391998
• 负责人: MURIEL T DAVISSON
• 金额: $ 30.43万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391998
• 关键词: MOUSE; MUTANT; RESOURCE; AIDS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regarding AIDS DESCRIPTION (provided by applicant): The mission of the Mouse Mutant Resource (MMR) at TJL is to provide a continuing source of new spontaneous mutations for biomedical and biological research. Spontaneous mutations in the mouse are a major source of models for human disorders and have the advantage over genetically engineered mutations in that they are first recognized by producing relevant phenotypes and do not require prior knowledge of the underlying genes. The specific objectives of the MMR program are to: (1) discover new spontaneous mutations in the mouse; (2) characterize the new mutants genetically, phenotypically, and pathologically; (3) establish the new mutations in strains suitable for further analysis; (4) preserve the mutations as frozen embryos or gametes to assure their continued availability and as DNA for future molecular analysis; (5) provide mutant mice and controls to other investigators; and (6) provide information about the mutant mice to others. The new mutations are discovered from among phenotypic deviants appearing in TJL large breeding colonies. They are characterized genetically by determining the mode of inheritance, testing for allelism with known mutations that produce a similar phenotype, and determining the chromosomal location. Each new mutant is characterized phenotypically by observing its growth, viability, fertility, life span, and behavior, and by defining its anatomical, histopathological, and physiological abnormalities. For selected mutants whose phenotype resembles that of an important human disease, the investigators will do further genetic and molecular analysis to identify the mutant gene. The investigators do more in depth analysis on mutants with phenotypes for which a member of the group or a collaborator has specific expertise. The MMR team has expertise in hearing, vision, bone biology, reproduction, and neuropathology. All new mutants with potential for biomedical research will be maintained, preserved as frozen embryos and DNA, and described in the open literature and/or on the MMR and TJL Websites. The overall purpose of the MMR is to make new mutant models available to other investigators for biomedical research.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。关于艾滋病描述(由申请人提供)：TJL的小鼠突变资源(MMR)的使命是为生物医学和生物研究提供新的自发突变的持续来源。小鼠的自发突变是人类疾病模型的主要来源，与基因工程突变相比，它们的优势在于它们首先通过产生相关的表型来识别，而不需要事先了解潜在的基因。MMR计划的具体目标是：(1)在小鼠身上发现新的自发突变；(2)从遗传学、表型和病理学上表征新的突变；(3)建立适合进一步分析的菌株的新突变；(4)以冷冻胚胎或配子的形式保存突变，以确保它们继续可用并作为DNA用于未来的分子分析；(5)向其他研究人员提供突变小鼠和对照；以及(6)向其他研究人员提供有关突变小鼠的信息。新的突变是从TJL大型繁殖群体中出现的表型异常中发现的。它们的遗传学特征是确定遗传模式，测试产生类似表型的已知突变的等位基因，并确定染色体位置。每个新的突变体通过观察其生长、活力、生育能力、寿命和行为，并通过定义其解剖、组织病理和生理异常来表征其表型。对于表型与人类一种重要疾病的表型相似的选定突变体，研究人员将进一步进行遗传和分子分析，以确定突变基因。研究人员对具有表型的突变进行了更深入的分析，这些突变的表型是该小组的成员或合作者具有特定专业知识的。MMR团队在听力、视觉、骨生物学、生殖和神经病理学方面拥有专业知识。所有具有生物医学研究潜力的新突变将作为冷冻胚胎和DNA进行维护和保存，并在公开文献和/或MMR和TJL网站上进行描述。MMR的总体目的是使新的突变模型可供其他研究人员用于生物医学研究。