Genetic regulation of avian sex determination

鸟类性别决定的遗传调控

• 批准号: DP200100709
• 负责人: A/Prof Craig Smith
• 金额: $ 37.77万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100709
• 关键词: Genetic; regulation; avian; sex; determination

This project aims to enhance our understanding of gonadal sex determination (testis versus ovary development), using innovative genetic approaches that exploit the avian embryo as a model system. The project aims to define the key molecular events regulating gonadal sex determination in birds. It intends to enhance knowledge in the area of cell biology, embryology, and sex determination specifically. Importantly, it will have application to the poultry industry. Currently, half of all hatchlings (the undesired sex) are culled. The proposed project intends to illuminate those genetic pathways that can be targeted to produce single-sex lines of birds, a major goal of the multi-billion dollar Australian and global poultry industries.

该项目旨在提高我们对性腺性别决定（睾丸与卵巢发育）的理解，使用创新的遗传方法，利用鸟类胚胎作为模型系统。该项目旨在确定调节鸟类性腺性别决定的关键分子事件。它旨在提高细胞生物学，胚胎学和性别决定领域的知识。重要的是，它将应用于家禽业。目前，一半的孵化（不受欢迎的性别）被淘汰。拟议的项目旨在阐明那些可以有针对性地生产单性别鸟类的遗传途径，这是数十亿美元的澳大利亚和全球家禽业的主要目标。