Defining a role for non-coding RNAs in gonadal sex differentiation.

定义非编码 RNA 在性腺性别分化中的作用。

• 批准号: DP160104638
• 负责人: A/Prof Craig Smith
• 金额: $ 22.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-04-14 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104638
• 关键词: Defining; role; non; coding; RNAs

This project aims to increase knowledge in the area of developmental biology, studying how gene regulation by so-called non-coding RNAs contributes to tissue patterning. The project plans to use a unique model system: gonadal development in the chicken embryo. It also plans to use novel molecular approaches that exploit the chicken model to study the role of microRNAs and a long non-coding RNA in patterning the embryonic gonad. The project aims to provide a deeper understanding of how genes operate to control tissue patterning and organogenesis. It may thus inform the field of sex determination specifically, and, more broadly, stem cell biology and tissue engineering.

该项目旨在增加发育生物学领域的知识，研究所谓的非编码RNA调节基因如何有助于组织模式。该项目计划使用独特的模型系统：鸡肉胚胎中的性腺发育。它还计划使用新型的分子方法来利用鸡模型来研究microRNAS和长的非编码RNA在构造胚胎性腺中的作用。该项目旨在更深入地了解基因如何控制组织模式和器官发生。因此，它可以特异性地确定性别的领域，更广泛地是干细胞生物学和组织工程。