ERG FIELD TOPOGRAPHY AND SOURCE IDENTIFICATION

远景目标：该项目将为未来的应用奠定基础 一种新的强大的功能成像技术用于检测和 人类视网膜功能障碍的研究。拟议的研究将 有助于建立两国之间的联系 人类ERG反应的成分和已知的视网膜机制 动物模型中的电生理学研究。 在之前的项目期间，功能成像的概念由 成功地建立了多输入非线性系统的分析方法 在几个项目和许多试点研究中进行了测试。新的方法论 已经进化到现在将被用来分离和 描述信号成分，特别是来自视网膜内部的信号成分。 视网膜处理中的非线性，主要是由于适应性 将使用机制来区分信号源。他们的 然后将地形分布与已知的解剖结构进行比较 用于识别来源的属性。该项目将解决 围绕图形ERG和振荡的长期争论 潜力，并为早期检测和表征铺平道路 青光眼损害。 具体目标是： 1.受试前后ERG成分的区分 明视视网膜电图的机制。后继动力的测定 接受性适应。2.视网膜电信号成分的识别 近端视网膜的形态分布 非线性特性。这些病变的病理变化研究 在青光眼患者中的成分。3.本地化和特色化 在中间水平上观察到的缓慢适应机制和 似乎是由杆状媒介引起的。4.检验假设是否发生变化 ERG的近端成分(特别是潜伏期增加 图形视网膜电信号和振荡电位)。 中心可归因于适应池。5.空间分析 远程空间适应的程度和动态。

Long-range Goal: The project will lay foundation for future applications of a new and powerful functional imaging techniques for the detection and study of retinal dysfunction in man. The proposed studies will contribute significantly to establishing the connection between components of the ERG response in man and retinal mechanisms known from electrophysiological studies in animal models. During the previous project period the concept of functional imaging by means of multi-input nonlinear system analysis has been successfully tested in several projects and numerous pilot studies. A new methodology of source identification has evolved that will now be used to isolate and characterize signal components, particularly those from the inner retina. Nonlinearities in retinal processing which are primarily due to adaptive mechanisms will be used to discriminate signal sources. Their topographic distribution will then be compared with known anatomical properties for identification of the sources. The project will resolve standing controversies surrounding the pattern ERG and the oscillatory potentials and pave the way to early detection and characterization of glaucomatous damage. Specific aims are: 1. Discrimination of ERG components from pre- and post-receptoral mechanisms in the photopic ERG. Determination of the dynamics of post- receptoral adaptation. 2. Identification of ERG components from the proximal retina by means of the topographic distribution of their nonlinear characteristics. Study of pathological changes of these components in glaucoma patients. 3. Localization and characterization of slow adaptive mechanisms that are observed at mesopic levels and appear to be rod mediated. 4. Test of the hypothesis that changes in proximal components of the ERG (particularly latency increases in the pattern electroretinogram and the oscillatory potentials) toward the center are attributable to adaptation pooling. 5. Analysis of spatial extent and dynamics of long-rang spatial adaptation.