Visually Modulated Endogenous Activity

视觉调节内源性活动

• 批准号: 6879493
• 负责人: ERICH E SUTTER
• 金额: $ 17.47万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6879493
• 关键词: attention; behavioral /social science research tag; brightness discrimination; color visions; electroencephalography; electrophysiology; evoked potentials; form /pattern perception; human subject; neural information processing; vision; visual perception; visual stimulus

DESCRIPTION (provided by applicant): The goal of this project is to test a model of top-down visual processing by noninvasive means in alert human observers. According to this model, the CNS actively explores the visual input, interacting with it through its endogenous activity. The interactions result in a temporal encoding of visual information that will be called visually modulated endogenous activity (VMEA). This response component does not need to correlate directly with abrupt changes in stimulus features and therefore eludes the commonly used techniques of stimulus-locked averaging. The existence of this component can be predicted in any system where the input interacts nonlinearly with fast endogenous processes and has been demonstrated in our pilot study using unconventional analysis tools. It shares many properties with the stimulus dependent synchronized high frequency oscillations found in animal studies. The method used in this study demodulates the endogenous carrier by means of nonlinear operations to retrieve its visual content. One of our aims is to optimize the stimulation and demodulation technique for the problem at hand. Other aims are to investigate the characteristics of the VMEA component and the role it may play in human visual perception. Specifically, we will study its dependence on the attentional state of the subject. We will investigate its dependence on stimulus geometry and color and we will compare the VMEA responses to random patterns with those to meaningful images with similar brightness contrast distributions.

描述（由申请人提供）：本项目的目标是通过非侵入性手段在警觉的人类观察者中测试自上而下的视觉处理模型。根据该模型，CNS积极探索视觉输入，并通过其内源性活动与视觉输入相互作用。这种相互作用导致视觉信息的时间编码，这将被称为视觉调节内源性活动（VMEA）。这种反应成分不需要与刺激特征的突然变化直接相关，因此避开了常用的刺激锁定平均技术。该成分的存在可以在任何输入与快速内生过程非线性相互作用的系统中进行预测，并且已经在我们使用非常规分析工具的试点研究中得到证明。它与动物实验中发现的依赖刺激的同步高频振荡有许多相同的特性。本研究使用的方法是通过非线性运算解调内源性载体来检索其视觉内容。我们的目标之一是优化当前问题的刺激和解调技术。其他目的是调查