VER AND ERG TECHNIQUES FOR REHABILITATION AND DIAGNOSTIC

用于康复和诊断的 VER 和 ERG 技术

• 批准号: 3263549
• 负责人: ERICH E SUTTER
• 金额: $ 18.5万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3263549
• 关键词: cone cell; diagnosis quality /standard; electroretinography; evoked potentials; eye disorder diagnosis; light adaptations; psychophysics; rehabilitation; rod cell; visual fixation; visual stimulus

This research plan includes two projects based on the same methodology: 1) Oculo-Encepalographic Communication (OEC). This project will establish a new method of communication and environmental contorl by means of the visual evoked potential. Information is communicated by visual fixation of one out of a number of flickering visual targets. The selected target is identified from the observer's evoked response which is derived from a pair of scalp electrodes. A transportable experimental system has been constructed for evaluation of the concept with communicatively disable persons. Tests revealed possibilities of significant improvement in preformance through additional research not included in the orginal proposal. We propose to study: a. Use of less conspicuous motion stimuli for target modulation. b. Effects of light adaptation on various response componets. c. Improvement of performance through implantation of electrodes (animal study). 2) Objective perimetry and light adaptation tests for medical diagnostics. Preliminary experiments have shown that the multi-input systems analysis techniques developed for the OEC project can be used for ERG and VER perimetry. Such objective perimetry techniques are desirable clinical tools which have been sought in vain by many investigators. Bases on the first successful ERG and VER perimetry data, a research plan is proposed which will result in viable clinical procedures. It includes: a) Optimization of stimulus parameters for extraction of specific local response components. b) Separate measure of spatial distributions of rod and cone responses. c) Evaluation of the diagnostic potential of the techniques with selected patients. Psychophysically measured glare recovery is a power clinical stress test. Presently, there is no objective test available for the clinic. A modified version of the OEC systems analysis technique can be used to pursue the time course of dark adaptation and glare recovery processes in the ERG and VER. Its potential as an objective diagnostic tool will be investigated.

该研究计划包括基于相同方法的两个项目： 1)眼脑电通信（OEC）。 该项目将建立一种新的通信和环境方法， 通过视觉诱发电位控制。 信息 通过视觉固定的一个沟通的闪烁的视觉数量 目标的 所选目标是从观察者的诱发电位中识别的。 这是从一对头皮电极得到的反应。 可运输 实验系统已建成的概念评价， 通信残疾人。 测试显示， 通过进一步研究， 包括在原始提案中。 我们建议研究：a。 使用较少的 用于目标调制的显著运动刺激。 B. 光的影响 对各种响应元件的适应性。 C. 性能的改善 通过植入电极（动物研究）。 2)医学诊断用客观视野检查和光适应试验。 初步实验表明，多输入系统分析 为OEC项目开发的技术可以用于ERG和VER 视野检查 这样的客观视野检查技术是临床上期望的。 许多研究者徒劳地寻找的工具。 立足 首先成功的ERG和VER视野检查数据，提出了研究计划 这将导致可行的临床程序。 它包括：a） 刺激参数的优化用于特定局部提取 响应组件。 B）杆的空间分布的单独测量 和视锥细胞的反应 （c）评估诊断潜力 技术与选定的病人。 精神病学测量的眩光恢复是一个权力的临床压力测试。 目前，该诊所还没有客观的测试。 修饰的 OEC系统分析技术的一个版本可以用来追求 ERG中暗适应和眩光恢复过程的时间过程， VER. 它作为一种客观诊断工具的潜力将得到研究。