VER AND ERG TECHNIQUES FOR REHABILITATION AND DIAGNOSTIC

用于康复和诊断的 VER 和 ERG 技术

• 批准号: 3263549
• 负责人: ERICH E SUTTER
• 金额: $ 18.5万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3263549
• 关键词: cone cell; diagnosis quality /standard; electroretinography; evoked potentials; eye disorder diagnosis; light adaptations; psychophysics; rehabilitation; rod cell; visual fixation; visual stimulus

This research plan includes two projects based on the same methodology: 1) Oculo-Encepalographic Communication (OEC). This project will establish a new method of communication and environmental contorl by means of the visual evoked potential. Information is communicated by visual fixation of one out of a number of flickering visual targets. The selected target is identified from the observer's evoked response which is derived from a pair of scalp electrodes. A transportable experimental system has been constructed for evaluation of the concept with communicatively disable persons. Tests revealed possibilities of significant improvement in preformance through additional research not included in the orginal proposal. We propose to study: a. Use of less conspicuous motion stimuli for target modulation. b. Effects of light adaptation on various response componets. c. Improvement of performance through implantation of electrodes (animal study). 2) Objective perimetry and light adaptation tests for medical diagnostics. Preliminary experiments have shown that the multi-input systems analysis techniques developed for the OEC project can be used for ERG and VER perimetry. Such objective perimetry techniques are desirable clinical tools which have been sought in vain by many investigators. Bases on the first successful ERG and VER perimetry data, a research plan is proposed which will result in viable clinical procedures. It includes: a) Optimization of stimulus parameters for extraction of specific local response components. b) Separate measure of spatial distributions of rod and cone responses. c) Evaluation of the diagnostic potential of the techniques with selected patients. Psychophysically measured glare recovery is a power clinical stress test. Presently, there is no objective test available for the clinic. A modified version of the OEC systems analysis technique can be used to pursue the time course of dark adaptation and glare recovery processes in the ERG and VER. Its potential as an objective diagnostic tool will be investigated.

该研究计划包括两个基于相同方法的项目： 1）眼脑通讯（OEC）。 该项目将建立一种新的沟通和环境方法 通过视觉诱发电位进行控制。 信息是 通过对众多闪烁视觉中的一个进行视觉固定来传达 目标。 选定的目标是根据观察者的诱发来识别的 来自一对头皮电极的响应。 一个可运输的 已经构建了实验系统来评估该概念 沟通障碍人士。 测试揭示了以下可能性 通过额外的研究显着提高性能 包含在原始提案中。 我们建议研究： 使用较少 用于目标调制的明显运动刺激。 b. 光的影响 对各种响应组件的适应。 c. 提高绩效 通过植入电极（动物研究）。 2) 用于医学诊断的客观视野检查和光适应测试。 初步实验表明，多输入系统分析 为 OEC 项目开发的技术可用于 ERG 和 VER 视野检查。 这种客观的视野检查技术是临床所期望的 许多研究人员一直在徒劳地寻找工具。 依据 首次成功获得ERG和VER视野测量数据，提出研究计划 这将产生可行的临床程序。 它包括：a) 优化刺激参数以提取特定局部 响应组件。 b) 杆空间分布的单独测量 和锥体反应。 c) 评估诊断潜力 技术与选定的患者。 心理物理测量的眩光恢复是一种功率临床压力测试。 目前，临床上还没有可用的客观测试。 一个修改过的 OEC 系统分析技术的版本可用于追求 ERG 中暗适应和眩光恢复过程的时间进程 版本。 将研究其作为客观诊断工具的潜力。