VER AND ERG TECHNIQUES FOR REHABILITATION AND DIAGNOSTIC

用于康复和诊断的 VER 和 ERG 技术

• 批准号: 3263549
• 负责人: ERICH E SUTTER
• 金额: $ 18.5万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3263549
• 关键词: cone cell; diagnosis quality /standard; electroretinography; evoked potentials; eye disorder diagnosis; light adaptations; psychophysics; rehabilitation; rod cell; visual fixation; visual stimulus

This research plan includes two projects based on the same methodology: 1) Oculo-Encepalographic Communication (OEC). This project will establish a new method of communication and environmental contorl by means of the visual evoked potential. Information is communicated by visual fixation of one out of a number of flickering visual targets. The selected target is identified from the observer's evoked response which is derived from a pair of scalp electrodes. A transportable experimental system has been constructed for evaluation of the concept with communicatively disable persons. Tests revealed possibilities of significant improvement in preformance through additional research not included in the orginal proposal. We propose to study: a. Use of less conspicuous motion stimuli for target modulation. b. Effects of light adaptation on various response componets. c. Improvement of performance through implantation of electrodes (animal study). 2) Objective perimetry and light adaptation tests for medical diagnostics. Preliminary experiments have shown that the multi-input systems analysis techniques developed for the OEC project can be used for ERG and VER perimetry. Such objective perimetry techniques are desirable clinical tools which have been sought in vain by many investigators. Bases on the first successful ERG and VER perimetry data, a research plan is proposed which will result in viable clinical procedures. It includes: a) Optimization of stimulus parameters for extraction of specific local response components. b) Separate measure of spatial distributions of rod and cone responses. c) Evaluation of the diagnostic potential of the techniques with selected patients. Psychophysically measured glare recovery is a power clinical stress test. Presently, there is no objective test available for the clinic. A modified version of the OEC systems analysis technique can be used to pursue the time course of dark adaptation and glare recovery processes in the ERG and VER. Its potential as an objective diagnostic tool will be investigated.

这项研究计划包括基于相同方法的两个项目： 1)眼脑沟通(OEC)。 该项目将建立一种新的通信和环境保护方法 通过视觉诱发电位进行控制。信息是 通过对多个闪烁的视觉中的一个进行视觉固定来传达 目标。所选目标是从观察者的诱发的 来自一对头皮电极的反应。一辆可运输的 构建了用于评价该概念的实验系统 有沟通障碍的人。测试显示有可能 通过额外的研究说明显著提高绩效 包括在最初的提案中。我们建议研究：a.减少使用 用于目标调制的明显运动刺激。B.光的影响 适应不同的反应成分。C.绩效的提升 通过植入电极(动物研究)。 2)医学诊断中的客观视野检查和光适应试验。 初步的实验表明，多输入系统的分析 为OEC项目开发的技术可用于ERG和VER 周界勘测。这种客观视野检查技术在临床上是可取的。 许多调查人员寻找的工具都是徒劳的。基于 首次获得成功的ERG和VER视野数据，提出了研究计划 这将导致可行的临床程序。它包括：a) 用于特定局部提取的刺激参数的优化 响应组件。B)单独测量棒材的空间分布 和圆锥体响应。C)评价诊断的潜力。 精选病人的技术。 心理生理测量眩光恢复是一种强有力的临床应激测试。 目前，临床上还没有可用的客观测试。经过修改的A OEC系统分析技术的版本可用于追求 视网膜电图暗适应和眩光恢复过程的时间进程 版本。它作为客观诊断工具的潜力将被调查。