ERG & VEP: FIELD TOPOGRAPHY & SOURCE IDENTIFICATION

尔格

• 批准号: 3263552
• 负责人: ERICH E SUTTER
• 金额: $ 29.11万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3263552
• 关键词: cone cell; dark adaptation; diagnosis design /evaluation; diagnosis quality /standard; electroretinography; evoked potentials; eye disorder diagnosis; eye fundus photography; glaucoma; human subject; intraocular pressure; light adaptations; ophthalmoscopy; patient monitoring device; perimetry; psychophysics; retina disorder; retinal ganglion; rod cell; stimulus /response; visual cortex; visual fields; visual photoreceptor; visual stimulus

The field topography of evoked potentials is the dependent of the responses on the location of a small stimulus in the visual field. Field topographies are derived with a method of simultaneous stimulation of a large number of locations and extraction of the local responses from a single response signal. The techniques for such studies have been developed and tested. Goal 1: Determination of the field topography of the luminance and pattern ERGs and their components. Correlation of these topographies with densities of retinal receptors and ganglion cells. Inter-subject differences will be studied to establish a baseline for a clinical evaluation. Goal 2: Development of an objective test of local retinal function for the purpose of screening, diagnosis and monitoring of patients. The field plots will be derived from patients with specific etiologies (glaucoma, ocular hypertension, maculopathy). The plots will be compared with fundus images to establish the exact location of retinal areas with abnormal ERG responses. ERG fields will be compared with psychophysical fields to assess their sensitivity in the detection of local pathological changes. Goal 3: Identification and characterization of ERG components from different retinal layers. This will be achieved with different modes of pattern stimulation and techniques of nonlinear systems analysis. Goal 4: Identification of VEP components from different visual areas of cortex. Functional characterization of their sources on the basis of nonlinear systems analysis. The field topography of the VEP is very complex due to the convoluted cortical anatomy. For each stimulus location, the relative contributions to the response from various cortical sources are different. A principal component analysis (SVD) will be applied to the responses at locations of comparable eccentricity in the visual field, to determine the subspace spanned by the components from different sources. The kernel structure of the nonlinear responses will be used to identify and characterize the components within this subspace. The invariance of the components between subjects will be tested to confirm the decomposition.

诱发电位的场形貌取决于响应 视野中小刺激的位置。 场地 地形是通过同时刺激的方法得出的 大量位置并从本地响应中提取 单一响应信号。 此类研究的技术是 开发并测试。 目标 1：确定亮度和图案的场形貌 ERG 及其组件。 这些地形的相关性 视网膜受体和神经节细胞的密度。 学科间 将研究差异以建立临床基线 评估。 目标 2：开发局部视网膜功能的客观测试 筛查、诊断和监测患者的目的。 领域 绘图将从具有特定病因的患者（青光眼、 高眼压、黄斑病变）。 这些图将与眼底进行比较 图像以确定 ERG 异常的视网膜区域的确切位置 回应。 ERG 场将与心理物理场进行比较，以 评估其检测局部病理变化的敏感性。 目标 3：鉴定和表征 ERG 成分 不同的视网膜层。 这将通过不同的模式来实现 模式模拟和非线性系统分析技术。 目标 4：识别来自不同视觉区域的 VEP 组件 皮质。 其来源的功能表征基于 非线性系统分析。 由于复杂的结构，VEP 的场形非常复杂 皮质解剖学。 对于每个刺激位置，相对贡献 对不同皮质来源的反应是不同的。 一位校长 分量分析（SVD）将应用于以下位置的响应 视野中可比较的偏心率，以确定子空间 由来自不同来源的组件组成。 内核结构 非线性响应将用于识别和表征 该子空间内的组件。 各分量之间的不变性 受试者将接受测试以确认分解情况。