ERG FIELD TOPOGRAPHY AND SOURCE IDENTIFICATION

描述（改编自申请人的摘要）：长期目标：1。到 提供快速本地和横向增益控制机制的理解， 人类的视网膜2.为新的强大的应用奠定基础 功能成像技术在视网膜内层无创检测中的应用 青光眼和糖尿病早期的功能障碍。近期进展： 在以前的项目期间， 通过基于多输入非线性的多焦点技术 系统分析已被探索和技术已被确立为一个 有价值的科学和临床价值。我们的研究旨在检测 和局部视网膜功能障碍的映射，以及识别和 视网膜电图和VEP的来源的表征。患者 研究包括青光眼、年龄相关性黄斑变性、糖尿病 视网膜病变、视网膜色素变性、视神经病变以及一些感染 疾病视网膜电图中反映视网膜内部功能的成分及视网膜电图的研究 青光眼和糖尿病中这些成分变化的检测和绘图 已成为该项目的重点。已经取得了很大的进展， 神经节细胞信号的提取和映射。一个显著 成就是开发了增强和提取 神经节细胞轴突的一个组成部分靠近神经头。视觉诱发电位研究 包括分离皮层反应中的M和P成分， 多焦点源定位（协作）。未来的具体目标 项目周期：1.为了确定非线性的动力学和横向扩展， 人类视网膜中的适应机制， 最后一个项目时期。2. T检测和成像神经节细胞的损失 使用多焦ERG的青光眼反应。不同的刺激方式， 信号推导和分析技术将使用少量的 病人和正常人最佳方案将在更大的 患者和正常人的群体。3.为了验证这个假设， 和动力学的组件下调查1.是敏感的指标 糖尿病视网膜缺血的症状开发一种方法来映射功能变化 在糖尿病中。

DESCRIPTION (Adapted From The Applicant's Abstract): Long-range goal: 1. To provide an understanding of fast local and lateral gain control mechanisms in the human retina. 2. To lay the foundation applications of a new and powerful functional imaging technique for the noninvasive detection of inner retinal dysfunction in early stages of glaucoma and in diabetes. Recent progress: During the previous project periods, the concept of functional imaging of the retina by means of a multifocal technique based on multi-input nonlinear systems analysis has been explored and the technique has been established as a valuable scientific and clinical too. Our studies were aimed at the detection and mapping of local retinal dysfunction, and the identification and characterization of sources of the electroretinogram and the VEP. Patient studies included glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, optic neuropathy as well as some infection diseases. The study of ERG components reflecting inner retinal function and the detection and mapping of changes in these components in glaucoma and diabetes has become a major focus of this project. Much progress has been made toward the extraction and mapping of signals from ganglion cells. A notable achievement was the development of methods for the enhancement and extraction of a component from ganglion cell axons nears the nerve head. VEP studies included isolation of M and P components in the cortical response and multifocal source localization (collaboration). Specific aims for the next project period: 1. To determine dynamics and lateral spread of nonlinear adaptive mechanisms in the human retina using new techniques developed during the last project period. 2. T detect and image the loss of ganglion cell responses in glaucoma using the multifocal ERG. Different modes of stimulation, signal derivation and analysis techniques will be compared using a small number of patients and normals. The best protocol will be evaluated on larger populations of patients and normals. 3. To test the hypothesis that the range and dynamics of the components investigated under 1. are sensitive indicators of retinal ischemia in diabetes. To develop a method to map functional changes in diabetes.