ERG FIELD TOPOGRAPHY AND SOURCE IDENTIFICATION

ERG 现场地形图和源识别

• 批准号: 6051343
• 负责人: ERICH E SUTTER
• 金额: $ 46.19万
• 依托单位: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-05-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6051343
• 关键词: bioimaging /biomedical imaging; diabetic retinopathy; diagnosis design /evaluation; electroretinography; eye disorder diagnosis; glaucoma; human subject; macular degeneration; noninvasive diagnosis; optic neuritis; retinal adaptation; retinal ganglion; retinitis pigmentosa; visual fields; visual perception; visual photoreceptor; visual stimulus

DESCRIPTION (Adapted From The Applicant's Abstract): Long-range goal: 1. To provide an understanding of fast local and lateral gain control mechanisms in the human retina. 2. To lay the foundation applications of a new and powerful functional imaging technique for the noninvasive detection of inner retinal dysfunction in early stages of glaucoma and in diabetes. Recent progress: During the previous project periods, the concept of functional imaging of the retina by means of a multifocal technique based on multi-input nonlinear systems analysis has been explored and the technique has been established as a valuable scientific and clinical too. Our studies were aimed at the detection and mapping of local retinal dysfunction, and the identification and characterization of sources of the electroretinogram and the VEP. Patient studies included glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, optic neuropathy as well as some infection diseases. The study of ERG components reflecting inner retinal function and the detection and mapping of changes in these components in glaucoma and diabetes has become a major focus of this project. Much progress has been made toward the extraction and mapping of signals from ganglion cells. A notable achievement was the development of methods for the enhancement and extraction of a component from ganglion cell axons nears the nerve head. VEP studies included isolation of M and P components in the cortical response and multifocal source localization (collaboration). Specific aims for the next project period: 1. To determine dynamics and lateral spread of nonlinear adaptive mechanisms in the human retina using new techniques developed during the last project period. 2. T detect and image the loss of ganglion cell responses in glaucoma using the multifocal ERG. Different modes of stimulation, signal derivation and analysis techniques will be compared using a small number of patients and normals. The best protocol will be evaluated on larger populations of patients and normals. 3. To test the hypothesis that the range and dynamics of the components investigated under 1. are sensitive indicators of retinal ischemia in diabetes. To develop a method to map functional changes in diabetes.

DESCRIPTION (Adapted From The Applicant's Abstract): Long-range goal: 1. To provide an understanding of fast local and lateral gain control mechanisms in 人类视网膜。 2. To lay the foundation applications of a new and powerful functional imaging technique for the noninvasive detection of inner retinal dysfunction in early stages of glaucoma and in diabetes.近期进展： During the previous project periods, the concept of functional imaging of the retina by means of a multifocal technique based on multi-input nonlinear systems analysis has been explored and the technique has been established as a valuable scientific and clinical too. Our studies were aimed at the detection and mapping of local retinal dysfunction, and the identification and characterization of sources of the electroretinogram and the VEP.病人 studies included glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, optic neuropathy as well as some infection 疾病。 The study of ERG components reflecting inner retinal function and the detection and mapping of changes in these components in glaucoma and diabetes 成为了该项目的一大焦点。已取得很大进展 the extraction and mapping of signals from ganglion cells.一个值得注意的 achievement was the development of methods for the enhancement and extraction of a component from ganglion cell axons nears the nerve head. VEP研究 included isolation of M and P components in the cortical response and 多焦点源定位（协作）。下一步具体目标 project period: 1. To determine dynamics and lateral spread of nonlinear adaptive mechanisms in the human retina using new techniques developed during 最后一个项目期。 2. T检测和成像神经节细胞的损失 使用多焦点 ERG 对青光眼的反应。 Different modes of stimulation, signal derivation and analysis techniques will be compared using a small number 患者和正常人。最好的协议将在更大的范围内进行评估 populations of patients and normals. 3. To test the hypothesis that the range and dynamics of the components investigated under 1. are sensitive indicators 糖尿病引起的视网膜缺血。开发一种绘制功能变化图的方法 在糖尿病中。