ERG FIELD TOPOGRAPHY AND SOURCE IDENTIFICATION

描述(改编自申请者摘要)：远景目标：1.至 提供对快速本地和横向增益控制机制的了解 人类的视网膜。2.为新的、功能强大的应用奠定基础 功能成像技术在视网膜内膜无创检测中的应用 青光眼和糖尿病早期的功能障碍。最新进展： 在之前的项目期间，功能成像的概念 基于多输入非线性的多焦点视网膜检测技术 已经探索了系统分析，并将该技术确立为一种 具有重要的科学价值和临床价值。我们的研究就是为了检测 和局部视网膜功能障碍的标测，以及识别和 视网膜电流图和视觉诱发电位来源的表征。有耐心的 研究包括青光眼、老年性黄斑变性、糖尿病 视网膜病变、视网膜色素变性、视神经病变以及一些感染 疾病。反映视网膜内功能的视网膜电信号成分的研究 检测和定位青光眼和糖尿病患者这些成分的变化 已经成为这个项目的一个主要焦点。已经在以下方面取得了很大进展 神经节细胞信号的提取和映射。一个值得注意的问题 所取得的成就是改进和提取方法 神经节细胞轴突的成分靠近神经头。视觉诱发电位研究 包括分离皮质反应中的M和P成分，以及 多焦点震源定位(协作)。下一步的具体目标 项目周期：1.确定非线性的动力学和横向扩展 在人类视网膜中使用新技术开发的适应机制 最后一个项目期。2.检测和成像神经节细胞的丢失 多焦视网膜电图对青光眼的反应。不同的刺激模式， 信号的推导和分析技术将使用少量的 病人和正常人的关系。最好的协议将在更大的 病人和正常人的群体。3.检验假设范围 以及在1项下调查的组件的动态是敏感指标 糖尿病患者的视网膜缺血。开发一种绘制功能变化图的方法 糖尿病患者。

DESCRIPTION (Adapted From The Applicant's Abstract): Long-range goal: 1. To provide an understanding of fast local and lateral gain control mechanisms in the human retina. 2. To lay the foundation applications of a new and powerful functional imaging technique for the noninvasive detection of inner retinal dysfunction in early stages of glaucoma and in diabetes. Recent progress: During the previous project periods, the concept of functional imaging of the retina by means of a multifocal technique based on multi-input nonlinear systems analysis has been explored and the technique has been established as a valuable scientific and clinical too. Our studies were aimed at the detection and mapping of local retinal dysfunction, and the identification and characterization of sources of the electroretinogram and the VEP. Patient studies included glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, optic neuropathy as well as some infection diseases. The study of ERG components reflecting inner retinal function and the detection and mapping of changes in these components in glaucoma and diabetes has become a major focus of this project. Much progress has been made toward the extraction and mapping of signals from ganglion cells. A notable achievement was the development of methods for the enhancement and extraction of a component from ganglion cell axons nears the nerve head. VEP studies included isolation of M and P components in the cortical response and multifocal source localization (collaboration). Specific aims for the next project period: 1. To determine dynamics and lateral spread of nonlinear adaptive mechanisms in the human retina using new techniques developed during the last project period. 2. T detect and image the loss of ganglion cell responses in glaucoma using the multifocal ERG. Different modes of stimulation, signal derivation and analysis techniques will be compared using a small number of patients and normals. The best protocol will be evaluated on larger populations of patients and normals. 3. To test the hypothesis that the range and dynamics of the components investigated under 1. are sensitive indicators of retinal ischemia in diabetes. To develop a method to map functional changes in diabetes.