ERG FIELD TOPOGRAPHY AND SOURCE IDENTIFICATION

描述（改编自申请人的摘要）： 长期目标： 1. 到 提供对快速局部和横向增益控制机制的理解 人类视网膜。 2. 为新的、强大的应用程序奠定基础 用于无创检测视网膜内层的功能成像技术 青光眼和糖尿病早期阶段的功能障碍。近期进展： 在之前的项目期间，功能成像的概念 视网膜通过基于多输入非线性的多焦点技术 系统分析已被探索，该技术已被确立为 也具有重要的科学和临床价值。我们的研究旨在检测 局部视网膜功能障碍的绘制和绘图，以及识别和 视网膜电图和 VEP 来源的表征。病人 研究包括青光眼、年龄相关性黄斑变性、糖尿病 视网膜病变、色素性视网膜炎、视神经病变以及某些感染 疾病。反映视网膜内功能的ERG成分研究及 检测和绘制青光眼和糖尿病中这些成分的变化 成为了该项目的一大焦点。已取得很大进展 从神经节细胞中提取和映射信号。一个值得注意的 成就是开发了增强和提取方法 神经节细胞轴突的一个成分靠近神经头。 VEP研究 包括皮质反应中 M 和 P 成分的分离， 多焦点源定位（协作）。下一步具体目标 项目周期： 1. 确定非线性的动力学和横向扩展 使用在人类视网膜中开发的新技术的自适应机制 最后一个项目期。 2. T检测和成像神经节细胞的损失 使用多焦点 ERG 对青光眼的反应。不同的刺激方式， 将使用少量数据来比较信号推导和分析技术 患者和正常人。最好的协议将在更大的范围内进行评估 患者群体和正常人群体。 3. 检验范围的假设 1. 下研究的组件的动态和动态是敏感指标 糖尿病引起的视网膜缺血。开发一种绘制功能变化图的方法 在糖尿病中。

DESCRIPTION (Adapted From The Applicant's Abstract): Long-range goal: 1. To provide an understanding of fast local and lateral gain control mechanisms in the human retina. 2. To lay the foundation applications of a new and powerful functional imaging technique for the noninvasive detection of inner retinal dysfunction in early stages of glaucoma and in diabetes. Recent progress: During the previous project periods, the concept of functional imaging of the retina by means of a multifocal technique based on multi-input nonlinear systems analysis has been explored and the technique has been established as a valuable scientific and clinical too. Our studies were aimed at the detection and mapping of local retinal dysfunction, and the identification and characterization of sources of the electroretinogram and the VEP. Patient studies included glaucoma, age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, optic neuropathy as well as some infection diseases. The study of ERG components reflecting inner retinal function and the detection and mapping of changes in these components in glaucoma and diabetes has become a major focus of this project. Much progress has been made toward the extraction and mapping of signals from ganglion cells. A notable achievement was the development of methods for the enhancement and extraction of a component from ganglion cell axons nears the nerve head. VEP studies included isolation of M and P components in the cortical response and multifocal source localization (collaboration). Specific aims for the next project period: 1. To determine dynamics and lateral spread of nonlinear adaptive mechanisms in the human retina using new techniques developed during the last project period. 2. T detect and image the loss of ganglion cell responses in glaucoma using the multifocal ERG. Different modes of stimulation, signal derivation and analysis techniques will be compared using a small number of patients and normals. The best protocol will be evaluated on larger populations of patients and normals. 3. To test the hypothesis that the range and dynamics of the components investigated under 1. are sensitive indicators of retinal ischemia in diabetes. To develop a method to map functional changes in diabetes.