The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide

多胺的“新”生物化学：当代谢途径发生冲突时

• 批准号: DP200103530
• 负责人: Prof Des Richardson
• 金额: $ 30.74万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-08-17 至 2023-08-16
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103530
• 关键词: New; Biochemistry; Polyamines; When; Metabolic

Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyamines, as we have discovered that polyamines are regulated by iron at 2-major levels, involving >10-key polyamine pathway proteins. This proposal represents first-in-field studies specifically designed to dissect mechanisms involved in this relationship. Our Central Hypothesis is that iron regulates polyamine metabolism.

基本生物化学和增殖代谢调控仍然是细胞生物学知识的基本组成部分，使生物学和医学取得突破性进展。多胺是一种独特且普遍存在的低分子量胺，在许多生物过程中起着至关重要的作用，包括增殖、DNA/RNA合成等。这一提议将从机械上剖析多胺的“新”生物化学，因为我们发现多胺受铁在两个主要水平上调节，涉及&gt；10-关键多胺途径蛋白。这项提议代表了专门为剖析这种关系所涉及的机制而专门设计的第一项实地研究。我们的中心假设是铁调节多胺代谢。