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The effect of nitrogen monoxide on intracellular iron metabolism

The effect of nitrogen monoxide on intracellular iron metabolism
一氧化氮对细胞内铁代谢的影响
批准号:
DP0450213
负责人:
Prof Des Richardson
金额:
$17.76万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-04-15 至 2007-06-30

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中文摘要
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英文摘要
During our current ARC grant we discovered a novel relationship between energy metabolism and NO-mediated Fe efflux and showed that glutathione (GSH) is vital for this release mechanism (DR5,6). Intriguingly, this transport process is part of the cytotoxic effector machinery of activated macrophages against tumours, and requires further elucidation. We also showed that CO affects Fe metabolism by binding to Fe, and CO may modulate NO's function. We will:- (1) Examine if NO-mediated Fe release results in GSH efflux (2) Identify the mechanism of NO-mediated Fe efflux. (3) Assess the effect of inducing haem oxygenase 1 on Fe metabolism
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The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide
  • 批准号:
    DP200103530
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $30.74万
  • 财政年份:
    2020
  • 负责人:
    Prof Des Richardson
  • 依托单位:
Pharmacological and Pharmaceutical Development of Novel Drugs for Multiple Major Disease States
  • 批准号:
    nhmrc : GNT1159596
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $88.83万
  • 财政年份:
    2019
  • 负责人:
    Prof Des Richardson
  • 依托单位:
Biomedical Investigations of Pharmacology and Pathology for Disease Treatment
  • 批准号:
    nhmrc : 1062607
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $57.57万
  • 财政年份:
    2014
  • 负责人:
    Prof Des Richardson
  • 依托单位:
Biomedical Investigations of Pharmacology and Pathology
  • 批准号:
    nhmrc : GNT1062607
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $82.29万
  • 财政年份:
    2014
  • 负责人:
    Prof Des Richardson
  • 依托单位:
海外基金