The effect of nitrogen monoxide on intracellular iron metabolism
The effect of nitrogen monoxide on intracellular iron metabolism
批准号:
DP0450213
负责人:
Prof Des Richardson
金额:
$17.76万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-04-15 至 2007-06-30
中文摘要
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英文摘要
During our current ARC grant we discovered a novel relationship between energy metabolism and NO-mediated Fe efflux and showed that glutathione (GSH) is vital for this release mechanism (DR5,6). Intriguingly, this transport process is part of the cytotoxic effector machinery of activated macrophages against tumours, and requires further elucidation. We also showed that CO affects Fe metabolism by binding to Fe, and CO may modulate NO's function. We will:-
(1) Examine if NO-mediated Fe release results in GSH efflux
(2) Identify the mechanism of NO-mediated Fe efflux.
(3) Assess the effect of inducing haem oxygenase 1 on Fe metabolism
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会议论文
The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide
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批准号:DP200103530
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项目类别:Discovery Projects
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资助金额:$30.74万
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财政年份:2020
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负责人:Prof Des Richardson
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依托单位:
Pharmacological and Pharmaceutical Development of Novel Drugs for Multiple Major Disease States
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批准号:nhmrc : GNT1159596
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资助金额:$88.83万
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财政年份:2019
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依托单位:
Biomedical Investigations of Pharmacology and Pathology for Disease Treatment
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批准号:nhmrc : 1062607
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项目类别:Research Fellowships
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资助金额:$57.57万
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财政年份:2014
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负责人:Prof Des Richardson
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依托单位:
Biomedical Investigations of Pharmacology and Pathology
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批准号:nhmrc : GNT1062607
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项目类别:Research Fellowships
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资助金额:$82.29万
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财政年份:2014
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负责人:Prof Des Richardson
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依托单位:
The effect of nitrogen monoxide on intracellular iron metabolism
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批准号:DP1092734
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项目类别:Discovery Projects
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资助金额:$37.62万
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财政年份:2010
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负责人:Prof Des Richardson
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 571123
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项目类别:NHMRC Research Fellowships
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资助金额:$52.99万
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财政年份:2009
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负责人:Prof Des Richardson
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依托单位:
Lipocalin 2 in host defence of the central nervous system
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批准号:nhmrc : 512408
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项目类别:NHMRC Project Grants
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财政年份:2008
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负责人:Prof Des Richardson
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依托单位:
Development of Iron Chelators for the Treatment of Friedreichs Ataxia and the Role of Frataxin in Iron Metabolism
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批准号:nhmrc : 512377
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项目类别:NHMRC Project Grants
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资助金额:$36.74万
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财政年份:2008
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负责人:Prof Des Richardson
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依托单位:
The Effect of Nitrogen Monoxide on Intracellular Iron Metabolism
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批准号:DP0773777
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项目类别:Discovery Projects
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资助金额:$26.15万
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财政年份:2007
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负责人:Prof Des Richardson
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依托单位:
Research Fellowship - Grant ID:457090
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批准号:nhmrc : 457090
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项目类别:NHMRC Research Fellowships
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资助金额:$17.55万
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财政年份:2007
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负责人:Prof Des Richardson
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依托单位:
Potential anti-tumour agents: Iron chelators of the pyridoxal isonicotinoyl hydrazone class
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批准号:nhmrc : 400939
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项目类别:NHMRC Project Grants
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资助金额:$31.52万
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财政年份:2006
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负责人:Prof Des Richardson
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依托单位:
Mitochondrial Iron Overload and Friedreich's Ataxia: The Role of Frataxin in Iron and Haem Metabolism
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批准号:nhmrc : 350874
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项目类别:NHMRC Project Grants
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资助金额:$40.41万
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财政年份:2005
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负责人:Prof Des Richardson
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依托单位:
The Physiological and Pathophysiological Roles of Melanotransferrin
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批准号:nhmrc : 300457
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项目类别:NHMRC Project Grants
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资助金额:$34.24万
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财政年份:2004
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负责人:Prof Des Richardson
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 189730
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项目类别:NHMRC Research Fellowships
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资助金额:$39.36万
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财政年份:2002
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负责人:Prof Des Richardson
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依托单位:
Mitochondrial iron overload and Friedreich's ataxia: The role of frataxin in iron and haem metabolism
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批准号:nhmrc : 189720
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项目类别:NHMRC Project Grants
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资助金额:$19.07万
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财政年份:2002
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负责人:Prof Des Richardson
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依托单位:
isonicotinoyl hydrazone class
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批准号:nhmrc : 189710
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项目类别:NHMRC Project Grants
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资助金额:$20.09万
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财政年份:2002
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负责人:Prof Des Richardson
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依托单位:
The Physiological and Pathophysiological Roles of Melanotransferrin
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批准号:nhmrc : 151620
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项目类别:NHMRC Project Grants
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资助金额:$15.17万
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财政年份:2002
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负责人:Prof Des Richardson
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依托单位:
Role of transition metal ions and redox activity in the development of atherosclerotic plaques
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批准号:nhmrc : 151630
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项目类别:NHMRC Project Grants
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资助金额:$13.07万
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财政年份:2001
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负责人:Prof Des Richardson
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依托单位:
The role of tumour antigen, melanotransferrin, in iron uptake by human melanoma cells
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批准号:nhmrc : 981826
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项目类别:NHMRC Project Grants
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资助金额:$11.85万
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财政年份:1998
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负责人:Prof Des Richardson
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依托单位:
海外基金