The effect of nitrogen monoxide on intracellular iron metabolism

一氧化氮对细胞内铁代谢的影响

• 批准号: DP1092734
• 负责人: Prof Des Richardson
• 金额: $ 37.62万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-05-06 至 2013-05-04
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092734
• 关键词: effect; nitrogen; monoxide; intracellular; iron

We discovered that the crucial signalling molecule nitrogen monoxide (NO) mediates iron (Fe) and glutathione (GSH) release by the transporter MRP1 probably as an NO-Fe-GSH complex [DR(2006) PNAS USA 103:7670-5]. During our current ARC grant we have markedly extended these findings by showing that another molecule, GST Pi and MRP1 form part of a coordinated system that stores and transports NO as complexes of Fe and GSH, markedly extending NO half-life from milliseconds to hours. This has broad implications for understanding NO activity in many processes which have major vital health implications, including tumour cell killing by macrophages and blood pressure control.

我们发现，关键的信号分子一氧化氮（NO）介导转运蛋白MRP 1可能作为NO-Fe-GSH复合物释放铁（Fe）和谷胱甘肽（GSH）[DR（2006）PNAS USA 103：7670-5]。在我们目前的ARC资助期间，我们显着扩展了这些发现，表明另一种分子GST Pi和MRP 1形成了一个协调系统的一部分，该系统以Fe和GSH的复合物形式储存和运输NO，显着延长NO的半衰期从毫秒到小时。这对于理解许多过程中的NO活性具有广泛的意义，这些过程具有重大的重要健康影响，包括巨噬细胞杀死肿瘤细胞和血压控制。