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The effect of nitrogen monoxide on intracellular iron metabolism

The effect of nitrogen monoxide on intracellular iron metabolism
一氧化氮对细胞内铁代谢的影响
批准号:
DP1092734
负责人:
Prof Des Richardson
金额:
$37.62万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-05-06 至 2013-05-04

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中文摘要
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英文摘要
We discovered that the crucial signalling molecule nitrogen monoxide (NO) mediates iron (Fe) and glutathione (GSH) release by the transporter MRP1 probably as an NO-Fe-GSH complex [DR(2006) PNAS USA 103:7670-5]. During our current ARC grant we have markedly extended these findings by showing that another molecule, GST Pi and MRP1 form part of a coordinated system that stores and transports NO as complexes of Fe and GSH, markedly extending NO half-life from milliseconds to hours. This has broad implications for understanding NO activity in many processes which have major vital health implications, including tumour cell killing by macrophages and blood pressure control.
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The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide
  • 批准号:
    DP200103530
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $30.74万
  • 财政年份:
    2020
  • 负责人:
    Prof Des Richardson
  • 依托单位:
Pharmacological and Pharmaceutical Development of Novel Drugs for Multiple Major Disease States
  • 批准号:
    nhmrc : GNT1159596
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $88.83万
  • 财政年份:
    2019
  • 负责人:
    Prof Des Richardson
  • 依托单位:
Biomedical Investigations of Pharmacology and Pathology for Disease Treatment
  • 批准号:
    nhmrc : 1062607
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $57.57万
  • 财政年份:
    2014
  • 负责人:
    Prof Des Richardson
  • 依托单位:
Biomedical Investigations of Pharmacology and Pathology
  • 批准号:
    nhmrc : GNT1062607
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $82.29万
  • 财政年份:
    2014
  • 负责人:
    Prof Des Richardson
  • 依托单位:
海外基金