The effect of nitrogen monoxide on intracellular iron metabolism
The effect of nitrogen monoxide on intracellular iron metabolism
批准号:
DP1092734
负责人:
Prof Des Richardson
金额:
$37.62万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-05-06 至 2013-05-04
中文摘要
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英文摘要
We discovered that the crucial signalling molecule nitrogen monoxide (NO) mediates iron (Fe) and glutathione (GSH) release by the transporter MRP1 probably as an NO-Fe-GSH complex [DR(2006) PNAS USA 103:7670-5]. During our current ARC grant we have markedly extended these findings by showing that another molecule, GST Pi and MRP1 form part of a coordinated system that stores and transports NO as complexes of Fe and GSH, markedly extending NO half-life from milliseconds to hours. This has broad implications for understanding NO activity in many processes which have major vital health implications, including tumour cell killing by macrophages and blood pressure control.
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Uncoupled Research Fellowship
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Lipocalin 2 in host defence of the central nervous system
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Development of Iron Chelators for the Treatment of Friedreichs Ataxia and the Role of Frataxin in Iron Metabolism
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依托单位:
The Effect of Nitrogen Monoxide on Intracellular Iron Metabolism
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批准号:DP0773777
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财政年份:2007
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Research Fellowship - Grant ID:457090
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依托单位:
Potential anti-tumour agents: Iron chelators of the pyridoxal isonicotinoyl hydrazone class
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依托单位:
Mitochondrial Iron Overload and Friedreich's Ataxia: The Role of Frataxin in Iron and Haem Metabolism
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批准号:nhmrc : 350874
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资助金额:$40.41万
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The effect of nitrogen monoxide on intracellular iron metabolism
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依托单位:
The Physiological and Pathophysiological Roles of Melanotransferrin
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Uncoupled Research Fellowship
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批准号:nhmrc : 189730
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资助金额:$39.36万
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依托单位:
Mitochondrial iron overload and Friedreich's ataxia: The role of frataxin in iron and haem metabolism
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批准号:nhmrc : 189720
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isonicotinoyl hydrazone class
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批准号:nhmrc : 189710
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资助金额:$20.09万
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依托单位:
The Physiological and Pathophysiological Roles of Melanotransferrin
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Role of transition metal ions and redox activity in the development of atherosclerotic plaques
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The role of tumour antigen, melanotransferrin, in iron uptake by human melanoma cells
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负责人:Prof Des Richardson
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依托单位:
海外基金