Lipocalin 2 in host defence of the central nervous system

脂质运载蛋白 2 在宿主中枢神经系统防御中的作用

• 批准号: nhmrc : 512408
• 负责人: Prof Des Richardson
• 金额: $ 38.34万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipocalin-2-host-central-nervous/94687
• 关键词: Lipocalin; host; defence; central; nervous

Lipocalin 2 is a protein that is involved in protection of the host organism against bacterial infections. We have found that high levels of lipocalin 2 are produced by a variety of cells in the brain in response to not only bacterial products but also to infection with West Nile virus (WNV). WNV is a dangerous virus known to cause lethal encephalitis. This project will determine the role of lipocalin 2 in the defence of the host against WNV encephalitis.

脂质运载蛋白2是一种参与保护宿主生物体免受细菌感染的蛋白质。我们发现，大脑中的多种细胞不仅对细菌产物作出反应，而且对西尼罗河病毒（WNV）感染作出反应，都会产生高水平的脂质运载蛋白2。西尼罗河病毒是一种危险的病毒，已知会导致致命的脑炎。该项目将确定脂质运载蛋白2在宿主防御西尼罗河病毒脑炎中的作用。