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The Effect of Nitrogen Monoxide on Intracellular Iron Metabolism

The Effect of Nitrogen Monoxide on Intracellular Iron Metabolism
一氧化氮对细胞内铁代谢的影响
批准号：
DP0773777
负责人：
Prof Des Richardson
金额：
$26.15万
依托单位：
The University of Sydney
依托单位国家：
澳大利亚
项目类别：
Discovery Projects
财政年份：
2007
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2007-08-01 至 2010-12-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773777
关键词：
EffectNitrogenMonoxideIntracellularIron

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英文摘要
For the first time, we discovered that nitric oxide (NO) is actively transported from cells by a protein that is known to also transport glutathione (GSH). This is important, as NO was thought to passively diffuse from cells. Active transport overcomes the problems of diffusion which is inefficient and non-targeted. Moreover, NO is released as a complex with iron and GSH which markedly increases its half-life. These findings have broad implications for understanding the activity of NO in many processes which have major health implications, including tumour cell killing by macrophages, blood pressure etc.
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The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide
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  • 财政年份：
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  • 项目类别：
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  • 负责人：
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  • 依托单位：
海外基金