The Effect of Nitrogen Monoxide on Intracellular Iron Metabolism

一氧化氮对细胞内铁代谢的影响

• 批准号: DP0773777
• 负责人: Prof Des Richardson
• 金额: $ 26.15万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-08-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0773777
• 关键词: Effect; Nitrogen; Monoxide; Intracellular; Iron

For the first time, we discovered that nitric oxide (NO) is actively transported from cells by a protein that is known to also transport glutathione (GSH). This is important, as NO was thought to passively diffuse from cells. Active transport overcomes the problems of diffusion which is inefficient and non-targeted. Moreover, NO is released as a complex with iron and GSH which markedly increases its half-life. These findings have broad implications for understanding the activity of NO in many processes which have major health implications, including tumour cell killing by macrophages, blood pressure etc.

我们第一次发现一氧化氮（NO）是通过一种已知也可以转运谷胱甘肽（GSH）的蛋白质从细胞中主动转运的。这一点很重要，因为NO被认为是被动地从细胞中扩散。主动运输克服了扩散的问题，即效率低和无针对性。此外，NO作为与铁和GSH的复合物释放，这显著增加了其半衰期。这些发现对于理解NO在许多过程中的活性具有广泛的意义，这些过程具有重大的健康影响，包括巨噬细胞杀死肿瘤细胞，血压等。