Integrated RF coil and sample holder for magnetic resonance microscopy

用于磁共振显微镜的集成射频线圈和样品架

• 批准号: 131959
• 金额: $ 2.66万
• 依托单位: PULSETEQ LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131959
• 关键词: Integrated; RF; coil; sample; holder

Magnetic resonance imaging (MRI) is now well established as a tool in clinical diagnosis. MRI also has a potential role in very high resolution MRI, otherwise known as magnetic resonance microscopy (MRM) on small tissue samples. This ex-vivo MRM, in principle, allows substantial increase in sensitivity of the MRI measurements to detect cellular/molecular changes underlying disease compared with in-vivo MRI. This is essential for researchers to determine the biological/disease processes that leads to MRI changes in vivo, enhancing the translation of MRI methods to the clinical arena. However undertaking MRM on standard MRI scanners is limited by signal sensitivity and by the size and shape of commercial tissue sample holders. This project addresses these limitations with a new concept that integrates the sensor that detects the MRI signal, a new very high performance RF coil, into a specially designed tissue sample container. This will allow the system users to undertake MRM with image resolution of less than 100 micro-meters in reasonable scan times, this in turn will lead to a significant uptake of this bio-imaging techniques.

磁共振成像（MRI）现在已被确立为临床诊断的工具。MRI在非常高分辨率的MRI中也有潜在的作用，也称为小组织样本的磁共振显微镜（MRM）。原则上，与体内MRI相比，这种离体MRM允许显著增加MRI测量的灵敏度，以检测潜在疾病的细胞/分子变化。这对于研究人员确定导致体内MRI变化的生物学/疾病过程至关重要，从而增强MRI方法向临床竞技场的转化。然而，在标准MRI扫描仪上进行MRM受到信号灵敏度以及商业组织样本保持器的尺寸和形状的限制。该项目通过一个新概念解决了这些局限性，该概念将检测MRI信号的传感器（一种新的非常高性能的RF线圈）集成到一个专门设计的组织样本容器中。这将允许系统用户在合理的扫描时间内进行图像分辨率小于100微米的MRM，这反过来将导致这种生物成像技术的显著采用。